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Objective We aimed to assess the effect of SGLT2i on arrhythmias by conducting a meta-analysis using data from randomized controlled trials(RCTs). Background Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown cardioprotective effects via multiple mechanisms that may also contribute to decrease arrhythmias risk.
Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00989-0 A molecular autopsy is undertaken in cases of suddencardiacdeath with no definitive cause found after conventional autopsy, with the aim of identifying a pathological genetic variant that could account for the death.
Sympathetic nervous system hyperactivity plays a major role in the pathogenesis of ventricular arrhythmias following myocardial infarction (MI).1,2 1,2 The stellate ganglia are an important nexus point for sympathetic innervation to the heart.3
Abstract The limited literature and increasing interest in studies on cardiac electrophysiology, explicitly focusing on cardiac ion channelopathies and suddencardiacdeath in diverse populations, has prompted a comprehensive examination of existing research.
The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and suddencardiacdeath (SCD) caused by drug-induced QT prolongation, reports a new study.
Diabetes mellitus (DM) confers an increased risk of suddencardiacdeath (SCD) independent of its associated cardiovascular comorbidities. Diabetes mellitus induces adverse structural, electrophysiological, and autonomic cardiac remodeling which can increase one’s risk of ventricular arrhythmias and SCD.
A heart attack is a life-threatening condition, with patients remaining at risk of premature death long after the actual attack—50% to 60% of patients die subsequently as a result of suddencardiacdeath, triggered by cardiacarrhythmia.
Despite early evidence of an antiarrhythmic role of n-3 PUFA in the prevention of suddencardiacdeath and postoperative and persistent atrial fibrillation (AF), subsequent well-designed randomized trials have largely not shown an antiarrhythmic benefit.
Background Ventricular arrhythmias (VAs) frequently occur in the acute phase of myocarditis. Possible arrhythmic recurrences and the risk of suddencardiacdeath (SCD) in this setting are reasons for concern, and limited data have been published to guide clinical management of these patients.
Despite improved childhood survival in congenital heart disease (CHD) due to advances in management, late-onset suddencardiacdeath (SCD) from malignant ventricular arrhythmias remains a leading cause of mortality in adults with CHD (ACHD).
The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and suddencardiacdeath (SCD) caused by drug-induced QT prolongation, reports a new study in Heart Rhythm.
Background:Limited data exist on the incidence of severe QT prolongation (SQTP) in patients using antipsychotics or antidepressants and the associated risk of ventricular arrhythmias (VA) and suddencardiacdeath (SCD).Aims:This
The increased risk of arrhythmias and suddencardiacdeath (SCD) caused by drug-induced QT prolongation has been a prominent safety pharmacology concern for the last 30 years.
The relationship between sarcopenia and ventricular arrhythmia (VA) is unknown. Sarcopenia is a geriatric syndrome featuring muscle mass, strength, and function loss. It is strongly associated with faster progression of cardiovascular diseases and an increased risk of mortality.
Patients with such variants can present with a wide spectrum of arrhythmias but suddendeath is generally considered rare. Pathogenic genetic variants in the HCN4 (hyperpolarisation-activated and cyclic nucleotide-gated channel) gene can cause sinus node dysfunction, disrupting the function of the pacemaker region of the heart.
Dilated cardiomyopathy (DCM) is a common heart muscle disorder of nonischemic etiology associated with heart failure development and the risk of malignant ventricular arrhythmias and suddencardiacdeath.
Mitral annular disjunction (MAD) increases the risk of ventricular arrhythmias (VAs) and suddencardiacdeath in patients with mitral valve prolapse (MVP), but its arrhythmogenic basis is unknown.
Triggers for and/or the occurrence of suddencardiacdeath (SCD), and cardiacarrhythmias seem to follow such daily patterns. These clocks are found in virtually all cells in the body, including cardiomyocytes.
Concerns regarding the risk of cardiacarrhythmia and death have been raised, yet the burden of HCQ and CQ-related cardiac toxicities remains unclear. Concerns regarding the risk of cardiacarrhythmia and death have been raised, yet the burden of HCQ and CQ-related cardiac toxicities remains unclear.
Arrhythmogenic role of epicardial adipose tissue (EAT) in atrial arrhythmias is well established, but its effect on ventricular arrhythmias has been significantly less investigated. Since ventricular arrhythmias are thought to cause 75% to 80% of cases of suddencardiacdeath, this is not a trivial issue.
The severity of the condition can vary within families, with some family members exhibiting minor symptoms while others may die of heart failure or an arrhythmia causing suddencardiacdeath. DCM can be silent for months to years before symptoms begin. Eventually heart failure may develop, which is late-phase disease.
Examination of previously reported predictors of lethal ventricular arrhythmias or suddencardiacdeath (VA/SCD) by ECG in Brugada syndrome (BrS) is a manual measurement and lacks objectivity.
Inherited arrhythmias (IAs) account for a significant proportion of suddencardiacdeath (SCD) in young patients without overt heart disease. Recent studies have suggested that substantial proportion of IAs is much prevalent in East Asian people.
He developed cardiac arrest shortly after the ECG in Figure-1 was recorded. What is the most likely cause of this arrhythmia? Pleomorphic VT and SuddenCardiacDeath — Editorial by Liu and Josephson on potential mechanisms to explain the ECG appearance of Pleomorphic VT.
The wearable cardioverter defibrillator (WCD) is becoming a more and more widely used instrument for the prevention of suddencardiacdeath of patients either with a secondary prevention implantable cardioverter defibrillator indication or with a transient high risk of suddencardiacdeath.
Brugada syndrome (BrS) is a genetic heart disease that predisposes individuals to ventricular arrhythmias and suddencardiacdeath. Although implantable cardioverter-defibrillators (ICDs) and quinidine are primary treatments, recurrent BrS-triggered ventricular arrhythmias can persist.
The issue is relevant since some arrhythmias are associated to suddencardiacdeath occurring in young patients, and the overall risk does not cease during the early postpartum period. Arrhythmias were documented in all the patients during the first cardiological assessment.
Wearable cardioverter-defibrillator (WCD) is an alternative option for the prevention of suddencardiacdeath in patients at high risk for malignant ventricular arrhythmias.
Suddencardiacdeath in children and young adults is a relatively rare but tragic event whose pathophysiology is unknown at the molecular level. Evidence indicates that the main cardiac sodium channel (NaV1.5) and the strong inward rectifier potassium channel (Kir2.1)
ObjectivesThe occurrence of suddencardiacdeath (SCD) in competitive athletes has led to a discussion about appropriate preparticipation screening models. The role of an electrocardiogram (ECG) in routine testing remains controversial in current guidelines. A staged preparticipation screening was performed.
Patients with Brugada syndrome who are asymptomatic and have no ventricular tachycardia/ventricular fibrillation inducibility by programmed electrical stimulation are at extremely low risk of experiencing late life-threatening arrhythmias. Methods Patients with BrS ( n = 523; mean age, 51 ± 13 years; male, n = 497) were enrolled.
The main result of the CAST (CardiacArrhythmia Suppression Trial), shown in Figure 1,1 was completely unexpected: The suppression of ventricular ectopy with antiarrhythmic drugs (AADs) was associated with an increased incidence of lethal ventricular arrhythmias in patients with post–myocardial infarction (post-MI) at high risk of suddencardiacdeath (..)
A comprehensive list of marathon-related deaths on Wikipedia contains 47 cases of “death by marathon” in the U.S. A list of the causes of death reveals an underlying pattern. Many, but not all, are cardiac-related issues (i.e., heart attack, arrhythmia, underlying congenital heart abnormality).
Chugh’s leadership in arrhythmia research and care is extraordinary,” said Eduardo Marbán, MD, PhD , executive director of the Smidt Heart Institute. Particularly, his contributions to the suddencardiac arrest medical knowledge base have changed the way we think about this deadly condition that we might be able to prevent on a larger scale.”
During the intravenous lacosamide infusion, the patient developed suddencardiac arrest caused by ventricular arrhythmias necessitating resuscitation. Of note, the patient had a family history of suddencardiacdeath.
Long QT syndrome is most commonly an inherited condition associated with a risk of suddencardiacdeath. It is recognized that LQTS in the fetus may present as sinus bradycardia (SB), functional 2:1 atrioventricular block and ventricular arrhythmias (VA).
Studies of suddencardiacdeath (SCD) risk intend to specify substrate for fatal arrhythmia rescuable by defibrillator but presume cardiac cause. The Postmortem Systematic Investigation of SCD (POST SCD) study showed nearly half of presumed SCDs (pSCDs) are due to non-arrhythmic causes (e.g.,
There is an unmet need for better risk stratification for suddencardiacdeath in the era of primary prevention ICD therapy. Scar burden on LGE-CMR imaging may be a risk marker for ventricular arrhythmia post-myocardial infarction (MI).
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