HeartRhythm

JANUARY 26, 2024

Sympathetic nervous system hyperactivity plays a major role in the pathogenesis of ventricular arrhythmias following myocardial infarction (MI).1,2 1,2 The stellate ganglia are an important nexus point for sympathetic innervation to the heart.3

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Arrhythmia Sudden Cardiac Death Myocardial Infarction Tachycardia 80

HeartRhythm

APRIL 30, 2024

The relationship between sarcopenia and ventricular arrhythmia (VA) is unknown. Sarcopenia is a geriatric syndrome featuring muscle mass, strength, and function loss. It is strongly associated with faster progression of cardiovascular diseases and an increased risk of mortality.

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Sudden Cardiac Death Arrhythmia Cardiovascular Disease 40

Medical Xpress - Cardiology

JUNE 28, 2024

A heart attack is a life-threatening condition, with patients remaining at risk of premature death long after the actual attack—50% to 60% of patients die subsequently as a result of sudden cardiac death, triggered by cardiac arrhythmia.

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Sudden Cardiac Death Heart Attack Heart attacks Pacemaker 91

HeartRhythm

APRIL 30, 2024

Mitral annular disjunction (MAD) increases the risk of ventricular arrhythmias (VAs) and sudden cardiac death in patients with mitral valve prolapse (MVP), but its arrhythmogenic basis is unknown.

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Bicuspid/Mitral Sudden Cardiac Death Arrhythmia 40

Journal of Cardiovascular Pharmacology

MAY 7, 2024

Concerns regarding the risk of cardiac arrhythmia and death have been raised, yet the burden of HCQ and CQ-related cardiac toxicities remains unclear. Concerns regarding the risk of cardiac arrhythmia and death have been raised, yet the burden of HCQ and CQ-related cardiac toxicities remains unclear.

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Sudden Cardiac Death Arrhythmia Article Outcomes 40

HeartRhythm

NOVEMBER 13, 2023

Arrhythmogenic role of epicardial adipose tissue (EAT) in atrial arrhythmias is well established, but its effect on ventricular arrhythmias has been significantly less investigated. Since ventricular arrhythmias are thought to cause 75% to 80% of cases of sudden cardiac death, this is not a trivial issue.

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Arrhythmia Sudden Cardiac Death Research 40

HeartRhythm

APRIL 30, 2024

Examination of previously reported predictors of lethal ventricular arrhythmias or sudden cardiac death (VA/SCD) by ECG in Brugada syndrome (BrS) is a manual measurement and lacks objectivity.

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Sudden Cardiac Death Arrhythmia Electrocardiogram 40

HeartRhythm

APRIL 30, 2024

Inherited arrhythmias (IAs) account for a significant proportion of sudden cardiac death (SCD) in young patients without overt heart disease. Recent studies have suggested that substantial proportion of IAs is much prevalent in East Asian people.

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Pediatrics Sudden Cardiac Death Arrhythmia Heart Disease 40

Science Daily - Heart Disease

JANUARY 15, 2024

The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study.

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HeartRhythm

AUGUST 27, 2024

Sleep-disordered breathing (SDB) increases the risk of cardiac arrhythmias and sudden cardiac death.

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Medical Xpress - Cardiology

JANUARY 14, 2024

The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study in Heart Rhythm.

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Sudden Cardiac Death Heart Rhythm Arrhythmia 75

HeartRhythm

JANUARY 13, 2024

The increased risk of arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation has been a prominent safety pharmacology concern for the last 30 years.

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Sudden Cardiac Death Pharmacology Arrhythmia 71

HeartRhythm

APRIL 30, 2024

Repolarization heterogeneities are known to significantly influence susceptibility to arrhythmias, a leading cause of sudden cardiac death.

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Sudden Cardiac Death Arrhythmia 40

Heart BMJ

FEBRUARY 12, 2024

This approach has delivered a novel perspective on arrhythmia management, with important distinctions from other policymakers’ recommendations.

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Arrhythmia Sudden Cardiac Death Atrial Fibrillation Heart Rhythm 40

HeartRhythm

APRIL 30, 2024

Wearable cardioverter-defibrillator (WCD) is an alternative option for the prevention of sudden cardiac death in patients at high risk for malignant ventricular arrhythmias.

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Defibrillator Sudden Cardiac Death Arrhythmia 40

Journal of Cardiovascular Electrophysiology

FEBRUARY 8, 2024

Patients with Brugada syndrome who are asymptomatic and have no ventricular tachycardia/ventricular fibrillation inducibility by programmed electrical stimulation are at extremely low risk of experiencing late life-threatening arrhythmias. Methods Patients with BrS ( n  = 523; mean age, 51 ± 13 years; male, n  = 497) were enrolled.

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Arrhythmia Sudden Cardiac Death Tachycardia Risk Factors 40

Circulation: Genomic and Precision Medicine

FEBRUARY 28, 2024

Dilated cardiomyopathy (DCM) is a common heart muscle disorder of nonischemic etiology associated with heart failure development and the risk of malignant ventricular arrhythmias and sudden cardiac death.

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Cardiomyopathy Sudden Cardiac Death Heart Failure Article 72

HeartRhythm

JANUARY 17, 2024

Sudden cardiac death in children and young adults is a relatively rare but tragic event whose pathophysiology is unknown at the molecular level. Evidence indicates that the main cardiac sodium channel (NaV1.5) and the strong inward rectifier potassium channel (Kir2.1)

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Sudden Cardiac Death Arrhythmia 40

HeartRhythm

APRIL 30, 2024

Long QT syndrome is most commonly an inherited condition associated with a risk of sudden cardiac death. It is recognized that LQTS in the fetus may present as sinus bradycardia (SB), functional 2:1 atrioventricular block and ventricular arrhythmias (VA).

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Sudden Cardiac Death Bradycardia Arrhythmia 40

HeartRhythm

APRIL 30, 2024

Studies of sudden cardiac death (SCD) risk intend to specify substrate for fatal arrhythmia rescuable by defibrillator but presume cardiac cause. The Postmortem Systematic Investigation of SCD (POST SCD) study showed nearly half of presumed SCDs (pSCDs) are due to non-arrhythmic causes (e.g.,

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Sudden Cardiac Death Defibrillator Arrhythmia Stroke 40

HeartRhythm

JANUARY 29, 2024

The main result of the CAST (Cardiac Arrhythmia Suppression Trial), shown in Figure 1,1 was completely unexpected: The suppression of ventricular ectopy with antiarrhythmic drugs (AADs) was associated with an increased incidence of lethal ventricular arrhythmias in patients with post–myocardial infarction (post-MI) at high risk of sudden cardiac death (..)

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Sudden Cardiac Death Myocardial Infarction Arrhythmia 40

HeartRhythm

APRIL 30, 2024

There is an unmet need for better risk stratification for sudden cardiac death in the era of primary prevention ICD therapy. Scar burden on LGE-CMR imaging may be a risk marker for ventricular arrhythmia post-myocardial infarction (MI).

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Sudden Cardiac Death Risk Factors Myocardial Infarction Cardiomyopathy 40

Frontiers in Cardiovascular Medicine

MARCH 13, 2024

The issue is relevant since some arrhythmias are associated to sudden cardiac death occurring in young patients, and the overall risk does not cease during the early postpartum period. Arrhythmias were documented in all the patients during the first cardiological assessment.

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Cardiomyopathy Sudden Cardiac Death Outpatient Inpatient 59

HeartRhythm

APRIL 30, 2024

Sudden cardiac death (SCD) is one of the most important causes of mortality in the world. The Purkinje network has been implicated in MI-related arrhythmogenesis, but the precise mechanisms by which they may sustain electrical activity in the scar tissue and arrhythmias remain unknown.

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Myocardial Infarction Sudden Cardiac Death Electrophysiology Risk Factors 40

HeartRhythm

APRIL 30, 2024

Current clinical guidelines fall short in accurately identifying HCM patients at risk for sudden cardiac death due to VA.

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Sudden Cardiac Death Arrhythmia Risk Factors Cardiomyopathy 40

HeartRhythm

APRIL 30, 2024

Patients with adult congenital heart disease are at risk for ventricular arrhythmias (VAs) or sudden cardiac death.

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Sudden Cardiac Death Congenital Heart Disease Tachycardia Congenital 40

HeartRhythm

JUNE 3, 2024

Most patients with VT and structural heart disease preparing for ablation either have or are about to receive an implantable cardioverter defibrillator (ICD) shortly after the procedure to prevent sudden cardiac death from recurrent ventricular arrhythmias (VA).

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Sudden Cardiac Death Tachycardia Ablation Defibrillator 40

HeartRhythm

APRIL 30, 2024

Post-MI cardiac remodeling leads to heart failure and electrical aberrancies which result in lethal arrhythmias and sudden cardiac death. Morbidity and mortality rates after Myocardial Infarction (MI) remain high despite advancements in therapy.

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Myocardial Infarction Sudden Cardiac Death Heart Failure Arrhythmia 40

HeartRhythm

APRIL 30, 2024

For the past four decades, implantable cardioverter defibrillator (ICD) therapy has become the standard of care for preventing sudden cardiac death in high-risk individuals. The rate of ICD implantation has risen due to the increasing population age and the growing prevalence of cardiac arrhythmias.

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Atrial Fibrillation Defibrillator Sudden Cardiac Death Tachycardia 40

HeartRhythm

APRIL 30, 2024

Nearly 50% of patients with AFib have comorbid obstructive sleep apnea (OSA), and 75% of OSA patients report some form of arrhythmia. Untreated OSA increases likelihood of poor outcomes for AFib patients including failed treatment, heart failure, and sudden cardiac death.

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AFIB Sudden Cardiac Death Outcomes Heart Failure 40

HeartRhythm

APRIL 30, 2024

Contemporary antiarrhythmic treatment of Timothy syndrome 1 (TS1) is inadequate to prevent sudden cardiac death. Using electroanatomic mapping (EAM) we discovered cardiac activation delay, which creates the milieu for functional reentrant ventricular arrhythmias.

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Sudden Cardiac Death Pharmacology Electrophysiology Arrhythmia 40

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

During the intravenous lacosamide infusion, the patient developed sudden cardiac arrest caused by ventricular arrhythmias necessitating resuscitation. Of note, the patient had a family history of sudden cardiac death.

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Sudden Cardiac Death Coronary Angiogram Cardiac Arrest Laboratory 52

HeartRhythm

OCTOBER 19, 2023

Hypertrophic cardiomyopathy (HCM)-related sudden cardiac death (SCD) rates with contemporary management are low; however, high-intensity exercise can induce fatal arrhythmias in HCM patients. Thus, current guidelines recommend avoiding high-intensity exercise in HCM patients at high risk for SCD1,2.

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Exercise Cardiomyopathy Sudden Cardiac Death Cardiovascular Disease 40

All About Cardiovascular System and Disorders

MARCH 29, 2024

And right ventricular hypertrophy and the abnormal architecture of the right ventricle, can predispose to late arrhythmias and sudden cardiac death in repaired tetralogy of Fallot. That is why they need follow up for arrhythmias. Atrial arrhythmias are also common after TOF repair.

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Sudden Cardiac Death Pulmonary Stenosis Arrhythmia 52

HeartRhythm

OCTOBER 15, 2023

Sudden cardiac death remains the main killer of adults in industrialized countries and reentrant ventricular arrhythmia (VA) is its main underlying mechanism1.

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Sudden Cardiac Death Tachycardia Defibrillator Ablation 40

European Journal of Heart Failure

FEBRUARY 26, 2024

AR, arrhythmogenic; CI, confidence interval; CIF, cumulative incidence function; ECG, electrocardiogram; FLNC, filamin C; LMNA, lamin; MVA, major ventricular arrhythmia; NSVT, non-sustained ventricular tachycardia; RBM20, RNA binding motif 20; RMTL, restricted mean time lost; SCD, sudden cardiac death.

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Cardiomyopathy Sudden Cardiac Death Arrhythmia Tachycardia 40

HeartRhythm

SEPTEMBER 14, 2023

Approximately 60% of index presentations are due to ventricular arrhythmia or sudden cardiac death (SCD). The exact incidence is difficult to estimate because many patients remain undiagnosed or are misdiagnosed.

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Cardiomyopathy Sudden Cardiac Death Arrhythmia 40