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Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association

Circulation

In addition, exposure of the fetus or neonate to either persistent arrhythmias or antiarrhythmic medications may have yet-to-be-determined long-term developmental consequences. Treatment options are limited in the fetus and neonate because of limited vascular access, patient size, and the significant risk/benefit ratio of any intervention.

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Ruxolitinib as a CaMKII Inhibitor for the Treatment of Cardiac Arrhythmias: Applications and Prospects

HeartRhythm

Recent studies have highlighted the critical role of calcium/calmodulin-dependent protein kinase II (CaMKII) overactivation in the pathogenesis of various cardiac arrhythmias.

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Microvascular disease and arrhythmias: a renewed focus on the myocardial microvasculature?

Heart BMJ

Arrhythmias, and in particular atrial fibrillation (AF), are one of the greatest healthcare challenges of our time. Arrhythmia prediction models have long relied on conventional risk factors such as age, diabetes, hypertension, and history of myocardial infarction and heart failure.

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Tachyarrhythmias in congenital heart disease

Frontiers in Cardiovascular Medicine

Surgical modifications and hemodynamic changes increase the susceptibility to arrhythmias, impacting morbidity and mortality rates, with arrhythmias being the leading cause of hospitalizations and sudden deaths. Macroreentrant atrial tachycardias, particularly cavotricuspid isthmus-dependent flutter, are frequently reported.

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BS-469619-002 PHARMACOLOGIC RESCUE OF LOSS-OF-FUNCTION SCN5A CHANNELOPATHY

HeartRhythm

Loss-of-function SCN5A channelopathies, such as Brugada syndrome (BrS), are cardiac disorders marked by diminished sodium current (INa), conduction slowing, and lethal arrhythmias.

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PO-05-201 PHARMACOLOGICAL MODULATION OF THE ARRHYTHMIC SUBSTRATE IN TIMOTHY SYNDROME: A PORCINE MODEL STUDY

HeartRhythm

Using electroanatomic mapping (EAM) we discovered cardiac activation delay, which creates the milieu for functional reentrant ventricular arrhythmias. We thus developed a knock-in TS1 porcine model that reproduces all cardinal features of the human disease and as such represents a unique platform for drug testing.

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PO-05-044 FLUOROLESS CATHETER ABLATION OF AN ATRIAL TACHYCARDIA ORIGINATING FROM THE DISTAL LEFT ATRIAL APPENDAGE IN A PREGNANT WOMAN WITH TACHYCARDIA-INDUCED CARDIOMYOPATHY

HeartRhythm

Supraventricular tachycardias are the most common arrhythmias that occur during pregnancy. Pharmacologic therapy is often preferred in pregnant patients. When pharmacologic therapy fails, fluoroless catheter ablation utilizing electroanatomic mapping systems and intracardiac echocardiography (ICE) may be considered.