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Atrial arrhythmia and heart failure in congenital heart disease: a pas de deux with consequences

Heart BMJ

In adults with congenital heart disease (ACHD patients), atrial arrhythmias (AA) and heart failure (HF) are common. 1 Factors related to congenital heart disease, such as underlying anatomy, surgical repair technique and scars, can all be considered as AA substrates.

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Atrial arrhythmia and heart failure in adult patients with congenital heart disease: a retrospective cohort study

Heart BMJ

Background Atrial arrhythmias (AA) and heart failure (HF) are major causes of hospitalisation in adult congenital heart disease (ACHD). Methods In this single-centre retrospective cohort study, data from 3995 patients with ACHD were analysed.

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New therapeutic target for cardiac arrhythmias emerges

Science Daily - Heart Disease

Researchers identified a lipid that is involved in regulating cardiac ion channels, providing insights into possible mechanisms of cardiac arrhythmias in heart failure and a potential pathway for future therapeutic development.

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Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Long COVID-19 was associated with a higher risk of thromboembolic disorders [HR 3.12 (1.60, 6.08)], coronary heart disease [HR 1.61 (1.13, 2.31)], stroke [HR 1.71 (1.07,2.72)], arrhythmia [HR 1.60 (1.13, 2.26)], cardiomyopathy [HR 1.71 (1.12, 2.61)], myocarditis [HR 6.11 (4.17,8.94)], hypertension [HR 1.70 (1.56, 1.85)], heart failure [HR 1.72 (1.15,2.59)] (..)

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Predicting cardiac arrhythmia 30 minutes before it happens

Science Daily - Heart Disease

Atrial fibrillation is the most common cardiac arrhythmia worldwide with around 59 million people concerned in 2019. This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. It constitutes a significant burden to healthcare systems, making its early detection and treatment a major goal.

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Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundPDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value remains elusive.

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Is long-term beta-blocker therapy needed after a heart attack?

Science Daily - Heart Disease

ABYSS suggests that long-term beta-blocker therapy is recommended after an MI, even in the absence of heart failure, arrhythmia or uncontrolled hypertension.