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Geneticpredisposition to ventricular scarring is associated with heartfailure and ventricular arrhythmia. Although many pathogenic variants have been shown to predispose patients to poor outcomes, the impact of many VUS remains uncharacterized.
It encompasses a range of conditions, including coronary artery disease, heartfailure and arrhythmias. While lifestyle factors such as diet, exercise and smoking play a significant role in the development of heart disease, genetics also contribute substantially.
The aim is to assess the prevalence, clinical consequences, and geneticpredisposition of reduced EF in athletes.METHODS:Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4.4
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