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This is the proposed mechanism of precipitation of arrhythmias in Brugada syndrome during febrile episodes. There is a potential risk for drug challenge in that life threatening ventricular arrhythmias could be precipitated. This leads to shortening of action potential duration. With proper precautions, risk can be reduced.
Measurement of QT interval is very important, as QT prolongation can predispose to serious, life threatening ventricular arrhythmias. QT prolongation leads to torsades des pointes, which is a very serious arrhythmia. PR segment elevation and depression can occur in atrial infarction and pericarditis. to 0.43, normal range.
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