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Notwithstanding many insightful observations, the electrocardiogram (ECG) arguably ignited the big bang in our understanding of cardiac arrhythmias. The development of electrophysiology (EP) studies through intravascular catheters provided the leap to verifying mechanisms, setting the stage for interventions.
Methods In the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry, we analyzed outcomes among patients undergoing elective IV sotalol load for atrial arrhythmias (AT/AF). Results Among 163 total patients, 85 (52%) of patients underwent loading anticipating target oral dose of 80mg, compared with 78 (48%) for 120mg.
David Luria (left), Director of Electrophysiology at Hadassah Medical Center, and Ziv Menshes (right), CEO of CardioVia tim.hodson Tue, 04/08/2025 - 14:38 April 7, 2025 CardioVia, a medical device company specializing in advanced cardiac care solutions, has received U.S. and the EU suffer from cardiac arrhythmias.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Evidence from experimental systems and patients indicates that ventricular myocytes inPKP2arrhythmogenic cardiomyopathy have greatly reduced electrical coupling at gap junctions and reduced Na+current density.
Atrial fibrillation is the most prevalent arrhythmia with a lifetime risk of nearly 30%. Additional advantages include providing electrophysiology lab personnel with a lead-free working environment and avoiding radiation exposure for both patients and physicians. It has initially been performed with fluoroscopic catheter guiding.
Our work spans cardiac electrophysiology, metabolic research, and AI-driven ECG analysis. Whether you study HRV, arrhythmias, long-term ECG monitoring, or metabolic health, our platform can help. This is our fourth research project with University Hospital Basel, and we are excited about whats next.
While AF arises in old age, the combined effects of widespread structural, electrophysiological and autonomic remodeling make it difficult to discern the exact mechanisms of arrhythmia generation. Investigation prior to overt structural remodeling may therefore be required.
What Clinics Can Do to Protect the Diagnosis and Treatment of Cardiac Arrhythmias Scope of Reimbursement Cuts The release of the annual Proposed Medicare Physician Fee Schedule is an event that business leaders and caregivers in healthcare anxiously anticipate.
Evidence suggests a reduced incidence of ventricular and atrial arrhythmias in patients with dapagliflozin or empagliflozin treatment. It is unclear to what extent the reduced arrhythmia burden is due to direct effects of the SGLT2 inhibitors or is solely a marker of improved cardiac function.
the most commonly overlooked arrhythmia ( See My Comment at the bottom of the page in the May 1, 2023 — and the November 12, 2019 post , among others ). But over 95% likelihood in today's case supports the need to assume VT until proven otherwise. Why was it Wrong to Think the Rhythm was AFlutter?
BackgroundAtrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide, posing significant health burdens. The most productive journals were Europace and the Journal of Interventional Cardiac Electrophysiology. The institution with the largest output was The Icahn School of Medicine at Mount Sinai.
Establishing the precise mechanism of cardiac arrhythmias in the electrophysiology laboratory is one of the main requisites for a successful and safe ablation.
Personalized computational models ("digital twins") of cardiac electrophysiology (EP) based on clinical imaging have shown potential utility in arrhythmia prognostics and treatment planning.
A pacemaker modified for newborns' tiny bodies safely and effectively stabilized their heart rhythms for up to two years, according to new research published in Circulation: Arrhythmia and Electrophysiology.
We sought to evaluate the electrophysiological characteristics and durability of PFA lesions, encompassing not only PVI but also left atrium (LA) posterior lines and left posterolateral mitral isthmus lines in a series of consecutive patients with recurrent atrial tachyarrhythmias after an index PFA procedure using a pentaspline catheter.
Promising as a treatment option for life-threatening ventricular arrhythmias, cardiac stereotactic body radiotherapy (cSBRT) has demonstrated early antiarrhythmic effects within days of treatment. The mechanisms underlying the immediate and short-term antiarrhythmic effects are poorly understood.
With the unveiling of the Genesis System, Baptist Health Lexington has become the first in Kentucky, and one of the first in the world, to provide the latest advancement in robotic technology to treat cardiac arrhythmias. “We In 2006, Lewis realized something was not right with his heart during one of his regular outdoor runs.
The spatial ventricular gradient (SVG), a vectorcardiographic measure of electrical heterogeneity, has been associated with arrhythmic events over long-term follow-up, but its relationship with short-term inducibility of ventricular arrhythmias (VAs) is unclear.
BackgroundAcute myocardial ischemia (AMI)triggered ventricular arrhythmias are closely linked to maladaptive sympathetic hyperactivity mediated via the left stellate ganglion (LSG). Treated animals exhibited attenuated repolarization variability and reduced electrophysiological heterogeneity in ischemic myocardium. versus 12.331.76
However, the incidence of ventricular arrhythmias (VAs) is high in this population, both in the acute and delayed phases after implantation. Abstract Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heart failure refractory to medical therapy.
“As electrophysiologists, our primary goal is to improve the lives of our patients,” said Dr. Mario Volpicelli , Head of the Electrophysiology Unit of the hospital. Robotic Magnetic Navigation introduces the benefits of robotic precision and safety to cardiac ablation, a common minimally invasive procedure to treat arrhythmias.
Electroanatomic mapping (EM) has revolutionized the understanding and ablation of complex arrhythmias by providing simultaneous representation of electrogram timing, location, and voltage in both space and time.
Methods and Results A total of 323 consecutive FAT patients who underwent electrophysiological study and radiofrequency catheter ablation between January 2011 and March 2023 were selected for this study. Conclusion Significant age differences were observed in the distribution of FAT foci.
The field of invasive cardiac electrophysiology (EP) has witnessed extraordinary advancements over the past 57 years, beginning with the foundational recording of the His bundle electrogram in 1969 by Anthony Damato, MD.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Three months after the index procedure, patients underwent a repeat electrophysiology study to identify pulmonary vein reconnections. Forty patients underwent a repeat electrophysiology study. or acute reconnection (4% versus 14%;P=0.3)
In electrophysiology, innovation is king, but it is often incremental, and it almost always lacks rationale, comprehensive clinical documentation and relevance for hospitals that try to balance the increasing costs of new technology with increasing demand and reimbursement that just can’t keep pace.
There is limited data regarding safety, electrophysiologic characteristics and arrhythmia substrate during ventricular tachycardia (VT) ablation in patients with prior aortic valve replacement (AVR).
Ventricular tachycardia (VT) ablation in structural heart disease improves arrhythmia free survival. Procedural factors that influence these outcomes are not well described.
BackgroundIschemic cardiomyopathy (ICM) is the end stage of ischemic heart disease, in which ventricular remodeling contributes to a fatal ventricular arrhythmia, worsens heart function and unfavorable outcomes, and is related to persistent chronic inflammation. Journal of the American Heart Association, Ahead of Print.
Computational modeling of the heart has become an important research tool in cardiac electrophysiology and arrhythmias with recent advances in real-world applications. Artificial intelligence (AI) is revolutionizing cardiac arrhythmia management by aiding detection, predicting risk, and contributing to clinical decision-making.
Studies have shown that mutations in the RYR2 gene, which encodes the RyR2 protein, are linked to several cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), calcium release deficiency syndrome (CRDS), and atrial fibrillation (AF).
Adult patients with repaired Tetralogy of Fallot (rTOF) have a high incidence of ventricular arrhythmias from an early age due to slowly conducting anatomic isthmuses (SCAI) between valves and scars or patches from the repair.
The findings, led by investigators in the Smidt Heart Institute at Cedars-Sinai, published in Circulation: Arrhythmia and Electrophysiology. Patients who present with persistent atrial fibrillation at diagnosis are more likely to have certain risk factors as compared with patients with occasional atrial fibrillation (AFib).
BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.
Although the electrcardiographic and electrophysiological properties of ventricular arrhythmias (VA) from the vicinity of lateral tricuspid annulus (TA) have been reported in previous studies, their precise site of origin have not been addressed.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Epicardial radiofrequency catheter ablation (RFCA) of idiopathic ventricular arrhythmias (VAs) originating from the left ventricular summit (LVS) is challenging because of the anatomic barriers.
In this respect, the role of electrophysiology study (EPS) has been subject of debate. Risk stratification in Brugada syndrome (BrS) remains controversial. In some centers, it is common practice to use an implantable loop recorder (ILR) after a negative EPS to help risk stratification.
Myocardial calcium (Ca2+) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca2+ transient is linked to heart failure and ventricular arrhythmias.
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