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Background High-intensity physical activity has traditionally been discouraged in patients with hypertrophic cardiomyopathy due to concerns about triggering suddencardiacdeath. However, current guidelines adopt a more liberal stance, and evidence on risk factors for exercise-related suddencardiacdeath remains limited.
Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00989-0 A molecular autopsy is undertaken in cases of suddencardiacdeath with no definitive cause found after conventional autopsy, with the aim of identifying a pathological genetic variant that could account for the death.
Dilated cardiomyopathy (DCM) is a common heart muscle disorder of nonischemic etiology associated with heart failure development and the risk of malignant ventricular arrhythmias and suddencardiacdeath. Circulation: Genomic and Precision Medicine, Ahead of Print.
Peripartum Cardiomyopathy (PPCM) is a polymorphic myocardial disease occurring late during pregnancy or early after delivery. The issue is relevant since some arrhythmias are associated to suddencardiacdeath occurring in young patients, and the overall risk does not cease during the early postpartum period.
Researchers Elizabeth Jordan and Ray Hershberger, MD discuss the results of genetic tests that indicate a risk for dilated cardiomyopathy. Dilated cardiomyopathy can be a silent killer DCM is a condition in which the heart muscle weakens and the left ventricle enlarges. The Dilated Cardiomyopathy Consortium was funded by a $12.4
Objectives To describe a cohort of patients with arrhythmogenic left ventricular cardiomyopathy (ALVC), focusing on the spectrum of the clinical presentations. Twenty-one (41%) had normal echocardiogram, 13 (25%) a hypokinetic non-dilated cardiomyopathy (HNDC) and 17 (33%) a dilated cardiomyopathy (DCM).
Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by replacement of ventricular myocardial by fibrofatty scar tissue which underlies morpho-functional ventricular abnormalities and life-threatening ventricular arrhythmias potentially responsible of suddencardiacdeath (SCD), mostly in young people and athletes 1,2.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiomyopathy resulting from disordered function of the intercalated discs with mainly arrhythmic manifestation, which can be difficult to diagnose because of its variable presentation. The incidence of ARVC is reported to be 1:2000 to 1:5000.
Whether you’re gearing up for your Family Medicine or Cardiology Board Exam, you’ll need to master the topic of Hypertrophic Cardiomyopathy (HCM). It is crucial for every medical physician to recognize patients who are at risk of suddencardiacdeath due to their underlying medical condition.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Over the past decades, hypertrophic cardiomyopathy has become a contemporary treatable disease. There was a significant decline in the rates of suddencardiacdeath from 1990 (0.84%/y) to 2020 (0.31%/y).CONCLUSIONS:Dramatic
Hypertrophic cardiomyopathy (HCM)-related suddencardiacdeath (SCD) rates with contemporary management are low; however, high-intensity exercise can induce fatal arrhythmias in HCM patients. Thus, current guidelines recommend avoiding high-intensity exercise in HCM patients at high risk for SCD1,2.
BackgroundArrhythmogenic cardiomyopathy (ACM) is a genetic heart muscle disease, which presents with arrhythmias and suddencardiacdeath, along with progressive cardiac remodeling and myocardial inflammation. Journal of the American Heart Association, Ahead of Print.
Dilated cardiomyopathy with arrhythmic phenotype. Abstract Aims Dilated cardiomyopathy (DCM) with arrhythmic phenotype combines phenotypical aspects of DCM and predisposition to ventricular arrhythmias, typical of arrhythmogenic cardiomyopathy. During a median follow-up of 6 years (interquartile range 1.6–12.1),
BACKGROUND:No disease-specific therapy currently exists for arrhythmogenic right ventricular cardiomyopathy (ARVC), a progressive cardiogenetic condition conferring elevated risk for ventricular arrhythmias, heart failure, and suddencardiacdeath. Emerging gene therapies have the potential to fill this gap.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterised by fibrofatty replacement of the ventricular myocardium due to specific mutations, leading to ventricular arrhythmias and suddencardiacdeath. channels, Connexin 43 and Wnt signalling, potentially modifying myocardial fibrosis.
To improve arrhythmogenic cardiomyopathy (ACM) patient care four pillars of ACM research are necessary. The first pillar to improve ACM is cohort studies in which the genotype-specific natural history of disease is described, and subsequently genotype-specific risk calculators can be developed, such as the DSP and PLN risk calculators.
There is an unmet need for better risk stratification for suddencardiacdeath in the era of primary prevention ICD therapy. Scar burden on LGE-CMR imaging may be a risk marker for ventricular arrhythmia post-myocardial infarction (MI).
Most patients with VT and structural heart disease preparing for ablation either have or are about to receive an implantable cardioverter defibrillator (ICD) shortly after the procedure to prevent suddencardiacdeath from recurrent ventricular arrhythmias (VA).
A comprehensive list of marathon-related deaths on Wikipedia contains 47 cases of “death by marathon” in the U.S. A list of the causes of death reveals an underlying pattern. Many, but not all, are cardiac-related issues (i.e., heart attack, arrhythmia, underlying congenital heart abnormality).
When non-compaction is associated with left ventricular dysfunction it is called left ventricular non-compaction cardiomyopathy. Some of them may develop heart failure, arrhythmias, thromboembolic events and even suddencardiacdeath rarely. Reference Thilde O. Kock, Marie F.
Cardiovascular mortality, driven by suddencardiacdeath, is the main reason for dying while waiting for heart transplantation (HTx). Aims Timely referrals for transplantation and left ventricular assist device (LVAD) play a key role in favourable outcomes in patients with advanced heart failure (HF).
Brandão M, Desmoplakin Cardiomyopathy: Comprehensive Review of an Increasingly Recognized Entity. He said a screening test called cardiac-arrhythmic genome analysis is available in certain European centers. The role of the molecular autopsy in suddencardiacdeath in young individuals. J Clin Med. Semsarian, C.
It presents in acute, indeterminate, and chronic phases, with chronic cardiomyopathy being the most severe form, leading to heart failure, arrhythmias, and suddencardiacdeath. Introduction:Chagas disease is a significant cause of tropical disease-related mortality.
There are a number of things to look for in an ECG that can hint at arrhythmia as the cause of an apparent seizure. Arrhythmogenic cardiomyopathy Long QT syndrome Hypertrophic cardiomyopathy. The patient did not have a positive family history of epilepsy, suddencardiacdeath (SCD) or recurrent syncope.
The granulomatous inflammation affects the heart, causing an infiltrative cardiomyopathy The most common manifestations of cardiac sarcoidosis are atrioventricular (AV) block and ventricular tachyarrhythmias (VT). VT is the second most common presenting arrhythmia. Figure-2: Laddergram of the rhythm in today's initial ECG.
Abstract Introduction Despite advancements in implantable cardioverter-defibrillator (ICD) technology, suddencardiacdeath (SCD) remains a persistent public health concern. Time periods were chosen based on the establishment of the Arrhythmia Service in 2011.
CS has a range of clinical syndromes: impaired conduction, arrhythmias, heart failure, and suddencardiacdeath. A cardiac monitor revealed intermittent 2-1 AV block and high degree AV block occurring mostly during sleep. An echocardiogram revealed normal biventricular function and morphology. cm in size.
In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause. 2020) The un-disputable fact is ischemic DCM has a target to treat, though it is termed as cardiomyopathy. SCD is the leading cause of mortality in heart failure. Reference 1.
In most cases, rather, the culprit is gross ischemia due to myocardial infarction, cardiomyopathy, or advanced coronary artery disease. This is a circumstance in which there exists a single focus of arrhythmogensis, yet conducts through multiple exit sites and/or experiences shifting conduction properties for arrhythmia duration.
See this even more interesting and more dramatic and fascinating case: History of Hypertrophic Cardiomyopathy (HOCM), with Tachycardia and High Lactate = My Comment by K EN G RAUER, MD ( 10/28 /2023 ): = QUESTION: For clarity in Figure-1 — I've reproduced today's ECG without the long lead rhythm strip. If so — WHO to screen?
Suddencardiacdeath in cardiomyoptahies: incidence, risk factors and prevention. ABSTRACT Cardiomyopathies are a significant contributor to cardiovascular morbidity and mortality, mainly due to the development of heart failure and increased risk of suddencardiacdeath (SCD).
BACKGROUND:Exercise-induced cardiac remodeling can be profound, resulting in clinical overlap with dilated cardiomyopathy, yet the significance of reduced ejection fraction (EF) in athletes is unclear. During follow-up, no athletes developed symptomatic heart failure or arrhythmias. Circulation, Ahead of Print.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Sudden cardiacdeath is the most common cause of death in childhood hypertrophic cardiomyopathy (HCM). Recently, 2 risk scores have been developed to estimate the 5-year risk of suddencardiacdeath.
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