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The role of the molecular autopsy in sudden cardiac death in young individuals

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00989-0 A molecular autopsy is undertaken in cases of sudden cardiac death with no definitive cause found after conventional autopsy, with the aim of identifying a pathological genetic variant that could account for the death.

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Imagenetics for Precision Medicine in Dilated Cardiomyopathy

Circulation: Genomic and Precision Medicine

Dilated cardiomyopathy (DCM) is a common heart muscle disorder of nonischemic etiology associated with heart failure development and the risk of malignant ventricular arrhythmias and sudden cardiac death. Circulation: Genomic and Precision Medicine, Ahead of Print.

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The “arrhythmic” presentation of peripartum cardiomyopathy: case series and critical review of the literature

Frontiers in Cardiovascular Medicine

Peripartum Cardiomyopathy (PPCM) is a polymorphic myocardial disease occurring late during pregnancy or early after delivery. The issue is relevant since some arrhythmias are associated to sudden cardiac death occurring in young patients, and the overall risk does not cease during the early postpartum period.

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Black Families at Increased Risk of Inherited Heart Condition That Can Cause Heart Failure at a Young Age

DAIC

Researchers Elizabeth Jordan and Ray Hershberger, MD discuss the results of genetic tests that indicate a risk for dilated cardiomyopathy. Dilated cardiomyopathy can be a silent killer DCM is a condition in which the heart muscle weakens and the left ventricle enlarges. The Dilated Cardiomyopathy Consortium was funded by a $12.4

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Clinical presentations leading to arrhythmogenic left ventricular cardiomyopathy

Open Heart

Objectives To describe a cohort of patients with arrhythmogenic left ventricular cardiomyopathy (ALVC), focusing on the spectrum of the clinical presentations. Twenty-one (41%) had normal echocardiogram, 13 (25%) a hypokinetic non-dilated cardiomyopathy (HNDC) and 17 (33%) a dilated cardiomyopathy (DCM).

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ATRIAL TACHYARRHYTHMIAS IN ARRHYTHMOGENIC CARDIOMYOPATHY

HeartRhythm

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by replacement of ventricular myocardial by fibrofatty scar tissue which underlies morpho-functional ventricular abnormalities and life-threatening ventricular arrhythmias potentially responsible of sudden cardiac death (SCD), mostly in young people and athletes 1,2.

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Pitfalls in the diagnosis of arrhythmogenic right ventricular cardiomyopathy

HeartRhythm

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiomyopathy resulting from disordered function of the intercalated discs with mainly arrhythmic manifestation, which can be difficult to diagnose because of its variable presentation. The incidence of ARVC is reported to be 1:2000 to 1:5000.