Ken Grauer, MD

SEPTEMBER 15, 2024

For full discussion of the case — CLICK HERE — ECG Rhythm Overview: A 12-year-old boy was admitted to our hospital with severe myocardial dysfunction and chaotic rhythm with tachy- and bradycardic arrhythmias. Hope this helps — :) ECG-3 — I see sinus bradycardia and arrhythmia.

Arrhythmia 78

Arrhythmia Bradycardia Heart Failure Pacemaker 78

Frontiers in Cardiovascular Medicine

JANUARY 10, 2024

Introduction Heart transplantation (HT) is the only treatment option in children with heart failure secondary to cardiomyopathies and non-reparable congenital heart diseases. 24 patients (88.8%) were diagnosed with dilated cardiomyopathy, 2 (7.4%) with restrictive cardiomyopathy, and 1 (3.7%) with hypertrophic cardiomyopathy.

Heart Transplant 59

Heart Transplant Transplant Arrhythmia Pacemaker 59

Frontiers in Cardiovascular Medicine

MARCH 6, 2024

Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has led to the modification of definition and classification of cardiomyopathy.

Cardiomyopathy 59

Cardiomyopathy Diabetes Article Obesity 59

HeartRhythm

DECEMBER 28, 2024

Desmoplakin (DSP) variants are associated with left-predominant or biventricular arrhythmogenic cardiomyopathy. Exercise promotes penetrance and sustained ventricular arrhythmias (VA) in right-sided arrhythmogenic right ventricular cardiomyopathy, but its effect is unknown in DSP variant carriers.

Exercise 81

Exercise Cardiomyopathy Arrhythmia 81

Circulation: Genomic and Precision Medicine

JANUARY 30, 2024

BACKGROUND:Pathogenic variants in PKP2 (plakophilin-2) cause arrhythmogenic right ventricular cardiomyopathy, a disease characterized by life-threatening arrhythmias and progressive cardiomyopathy leading to heart failure. Circulation: Genomic and Precision Medicine, Ahead of Print. In contrast, AAVrh.74-PKP2a–mediated

Cardiomyopathy 72

Cardiomyopathy Arrhythmia Cardiac Function Heart Failure 72

Medical Xpress - ECG

APRIL 17, 2023

Thirty day electrocardiogram (ECG) monitoring in patients with hypertrophic cardiomyopathy (HCM) detects more arrhythmias than the standard 24 to 48 hours, according to late breaking science presented at EHRA 2023, a scientific congress of the European Society of Cardiology (ESC).

Arrhythmia 40

Arrhythmia Cardiomyopathy Research Electrocardiogram 40

HeartRhythm

APRIL 30, 2024

Arrhythmias are common in patients with hypertrophic cardiomyopathy (HCM) and are associated with increased morbidity and mortality. Ventricular arrhythmias (VA) are less common compared to supraventricular arrhythmias yet are associated with worse outcomes in this patient population.

Arrhythmia 40

Arrhythmia Cardiomyopathy Ablation Outcomes 40

HeartRhythm

MARCH 25, 2025

Ventricular arrhythmias (VAs) may be the first clinical manifestation in pediatric patients with arrhythmogenic cardiomyopathy (ACM). The arrhythmogenicity of exercise testing (ET) remains unclear.

Pediatrics 40

Pediatrics Exercise Arrhythmia Cardiomyopathy 40

Frontiers in Cardiovascular Medicine

JANUARY 16, 2024

Nevertheless, studies on the long-term outcomes of catheter ablation in patients with dilated cardiomyopathy are limited. The recurrence rate of atrial arrhythmia was 30.4% ( n  = 14) after an average follow-up duration of 7.7 Introduction Catheter ablation is an effective and safe strategy for treating atrial fibrillation patients.

Atrial Fibrillation 64

Atrial Fibrillation Ablation Cardiomyopathy Heart Failure 64

Journal of Cardiothoracic Surgery

SEPTEMBER 22, 2024

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a family inherited cardiomyopathy associated with ventricular arrhythmias. With the development of molecular biology, histology, imaging, and other dia.

Cardiomyopathy 52

Cardiomyopathy Tachycardia Arrhythmia Ablation 52

HeartRhythm

APRIL 30, 2024

It has been approved for use in patients with severe obstructive hypertrophic cardiomyopathy (oHCM). Currently, there has been little data on ventricular arrhythmias in patients treated with mavacamten.

Arrhythmia 40

Arrhythmia Cardiomyopathy 40

European Journal of Heart Failure

DECEMBER 18, 2024

Impact of guideline-directed medical therapy for heart failure after left ventricular ejection fraction (LVEF) improvement in arrhythmia-induced cardiomyopathy. ( A ) Study flow chart. ( B ) Changes in renin-angiotensin-system (RAS) inhibitors and beta-blockers (BB) prescriptions after LVEF improvement. (

Heart Failure 40

Heart Failure Arrhythmia Cardiomyopathy Research 40

HeartRhythm

NOVEMBER 10, 2023

In arrhythmogenic right ventricular cardiomyopathy (ARVC), risk of atrial arrhythmias (AA) persists after ventricular tachycardia (VT) ablation.

Tachycardia 40

Tachycardia Arrhythmia Cardiomyopathy Ablation 40

HeartRhythm

DECEMBER 16, 2024

A gradual increase in arrhythmia recurrences during 12 months after catheter ablation (CA) of atrial fibrillation (AF) is still reported.1 A gradual increase in arrhythmia recurrences during 12 months after catheter ablation (CA) of atrial fibrillation (AF) is still reported.1

Atrial Fibrillation 40

Atrial Fibrillation Arrhythmia Cardiomyopathy Ablation 40

HeartRhythm

APRIL 30, 2024

Cardiac Sympathetic Denervation (CSD) has proven efficacy in Long-QTS syndrome (LQTS) patients with refractory ventricular arrhythmia (VA).1 1 However, owing to the limited prevalence of this procedure, outcomes in patients with other genetic cardiomyopathies remain less understood.

Arrhythmia 40

Arrhythmia Cardiomyopathy Outcomes 40

Dr. Smith's ECG Blog

JANUARY 2, 2025

And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. I do not see OMI here and all trops were only minimally elevated, consistent with either chronic injury from cardiomyopathy or with acute injury from sepsis.

Tachycardia 115

Tachycardia Cardiomyopathy Blog Bradycardia 115

HeartRhythm

APRIL 30, 2024

Decisions as to the scope of workup for pathologic cardiac substrates in patients with ventricular arrhythmias can be challenging. Recent data suggests that in this scenario, disease specific genetic arrhythmia panels may miss heritable diagnoses over arrhythmic plus cardiomyopathy panels.(1)

Arrhythmia 40

Arrhythmia Cardiomyopathy Tachycardia 40

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2023

Background Pathogenic/Likely pathogenic variants in DSP -encoded desmoplakin are strongly associated with arrhythmogenic cardiomyopathy (ACM). Workup including echocardiography, cardiac magnetic resonance imaging, and Holter monitor did not show evidence of ACM or significant arrhythmias.

Cardiomyopathy 64

Cardiomyopathy Arrhythmia Pacemaker Document 64

Frontiers in Cardiovascular Medicine

FEBRUARY 26, 2025

BackgroundAtrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide, posing significant health burdens. Keywords with strong recent citation bursts included tissue, cardiomyopathy, and closed chest ablation.ConclusionPFA is becoming established as a viable alternative for AF ablation, showing promising safety and efficacy.

Ablation 52

Ablation Atrial Fibrillation Research Electrophysiology 52

Frontiers in Cardiovascular Medicine

APRIL 8, 2025

Genetic factors are estimated to cause approximately 30%50% of dilated cardiomyopathy (DCM) cases, with Titin (TTN) being the most commonly implicated gene, accounting for 20%25% of genetic causes. Many DCM-causing TTN mutations are heterozygous truncating variants, including frameshift, non-sense, and essential splice site mutations.

Cardiomyopathy 52

Cardiomyopathy Arrhythmia 52

HeartRhythm

APRIL 30, 2024

Introduction: Pathogenic desmoplakin (DSP) variants are associated with left or biventricular arrhythmogenic cardiomyopathy. Exercise promotes penetrance and sustained ventricular arrhythmias (VA) in classic ARVC. It is unknown if exercise affects risk in DSP variant carriers.

Exercise 40

Exercise Arrhythmia Cardiomyopathy 40

HeartRhythm

APRIL 10, 2025

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) presents diagnostic challenges and significant clinical burden due to life-threatening ventricular arrhythmias, compounded by the limited ability to predict patient prognosis using current clinical parameters.

Cardiomyopathy 45

Cardiomyopathy Arrhythmia 45

European Journal of Heart Failure

FEBRUARY 5, 2025

Long-term follow-up (FU) of the TRED-HF trial: persistent high-risk of relapse following therapy withdrawal in recovered dilated cardiomyopathy (DCM), likely contributed to by low-dose therapy and exposure to external triggers. LVEF, left ventricular ejection fraction. This follow-up investigates the longer-term effects of therapy withdrawal.

Heart Failure 67

Heart Failure Cardiomyopathy Atrial Fibrillation Arrhythmia 67

Circulation: Arrhythmia and Electrophysiology

FEBRUARY 24, 2025

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Population genomic screening for desmosome variants associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) may facilitate early disease detection and protective intervention.

Arrhythmia 40

Arrhythmia Cardiomyopathy Electrophysiology Circulation 40

Dr. Smith's ECG Blog

JUNE 5, 2024

IMPRESSION: The finding of sinus bradycardia with 1st-degree AV block + marked sinus arrhythmia + the change in PR interval from beat #5-to-beat #6 — suggests a form of vagotonic block ( See My Comment in the October 9, 2020 post in Dr. Smith's ECG Blog ). Initial high sensitivity troponin I returned at 6ng/L (normal 0.20

Chest Pain 121

Chest Pain Blog Cardiac Arrest Cardiomyopathy 121

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Hypertrophic cardiomyopathy (HCM) is a very prevalent inherited disease with a wide global distribution and a prevalence rate of approximately 0.2% in the general population. Left ventricular hypertrophy (LVH) caused by sarcomere mutation is the primary reason of HCM.

Cardiomyopathy 52

Cardiomyopathy Article Arrhythmia 52

HeartRhythm

APRIL 30, 2024

Risk stratification in patients with non-ischemic cardiomyopathy (NICM) remains challenging. Although late gadolinium enhancement (LGE) CMR is recognized as a major risk factor for VT/VF, the prognostic value of LGE radiomics is unknown.

Cardiomyopathy 40

Cardiomyopathy Arrhythmia Risk Factors 40

Med Page Today

MARCH 10, 2025

(MedPage Today) -- Genetic testing for hereditary arrhythmia and cardiomyopathy in an area with known founder effects on local genetic variants had a high yield in identification of pathogenic variants by taking into account the local population.

Heart Disease 71

Heart Disease Cardiomyopathy Arrhythmia 71

Circulation: Arrhythmia and Electrophysiology

AUGUST 30, 2024

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Increased mitochondrial Ca2+uptake has been implicated in the QT prolongation and lethal arrhythmias associated with nonischemic cardiomyopathy. In a heterologous expression system, c-Src could bind MCU and phosphorylate MCU tyrosines.

Cardiomyopathy 40

Cardiomyopathy Arrhythmia Electrophysiology Circulation 40

Circulation: Cardiovascular Interventions

FEBRUARY 10, 2025

Hypertrophic cardiomyopathy is a common but underrecognized cardiac disorder characterized by a heterogenous phenotype that includes increased left ventricular thickness, outflow obstruction, diastolic dysfunction, and arrhythmia. Circulation: Cardiovascular Interventions, Ahead of Print.

Cardiomyopathy 40

Cardiomyopathy Quality of Life Bicuspid/Mitral Cardiovascular Interventions 40

HeartRhythm

AUGUST 25, 2023

Among patients with ischemic cardiomyopathy (ICM) and nonischemic cardiomyopathy (NICM), myocardial fibrosis is associated with an increased risk for ventricular arrhythmia (VA). Growing evidence suggests that myocardial fat contributes to ventricular arrhythmogenesis.

Arrhythmia 40

Arrhythmia Cardiomyopathy 40

Journal of Cardiothoracic Surgery

JANUARY 6, 2025

Tachycardia-induced cardiomyopathy refers to changes in cardiac structure and function that result from rapid arrhythmia and can manifest as a continuous or recurrent event. Cardiomyopathy induced by atrial ta.

Cardiomyopathy 40

Cardiomyopathy Tachycardia Arrhythmia Ablation 40

Journal of Cardiovascular Electrophysiology

NOVEMBER 7, 2024

Catheter ablation of atrial fibrillation in infiltrative cardiomyopathies ABSTRACT Atrial and ventricular arrhythmias are common in patients with Infiltrative heart diseases. AF is the most common arrhythmia identified in patients with amyloidosis due to cellular infiltration and atrial dilation.

Atrial Fibrillation 40

Atrial Fibrillation Ablation Cardiomyopathy Arrhythmia 40

HeartRhythm

AUGUST 18, 2024

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic heart disease associated with life-threatening ventricular arrhythmias. Diagnosis of ARVC is based on the 2010 Task Force Criteria (TFC), application of which often requires clinical expertise at specialized centers.

Cardiomyopathy 40

Cardiomyopathy Arrhythmia Heart Disease 40

HeartRhythm

APRIL 30, 2024

Duchenne muscular dystrophy (DMD) is an X-linked inherited disorder characterized by progressive muscle wasting and dilated cardiomyopathy. With improved multi-disciplinary care patients with left ventricular (LV) dysfunction surviving to older ages may be at risk for arrhythmias.

Cardiomyopathy 40

Cardiomyopathy Arrhythmia 40

HeartRhythm

APRIL 30, 2024

The efficacy of implantable cardioverter-defibrillators (ICD) in patients with a non-ischaemic cardiomyopathy (NICM) is being debated. Deep Learning models enable feature extraction from high-dimensional data, such as cardiac MRI (CMR) and ECG.

Cardiomyopathy 40

Cardiomyopathy Defibrillator Arrhythmia 40

Circulation: Arrhythmia and Electrophysiology

NOVEMBER 29, 2023

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Atrial cardiomyopathy is a condition that causes electrical and contractile dysfunction of the atria, often along with structural and functional changes.

Cardiomyopathy 40

Cardiomyopathy Atrial Fibrillation Electrophysiology Arrhythmia 40