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Unveiling the threat of crystalline silica on the cardiovascular system. A comprehensive review of the current knowledge

Frontiers in Cardiovascular Medicine

Specific cardiovascular diseases, such as acute myocardial infarction, arrhythmias, pulmonary hypertension and pericarditis, were also pointed. Elevated risk of arrhythmias, particularly atrial fibrillation, correlated with occupational silica exposure.

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Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation

Frontiers in Cardiovascular Medicine

BackgroundAtrial fibrillation (AF) is a common arrhythmia associated with an increased risk of stroke, heart failure, and mortality. Machine learning models, including Random Forest and Support Vector Machine (SVM), were applied to select potential AF-related diagnostic biomarkers, and validated in the animal model (beagles; n=6).ResultsA

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Circulating microRNAs as biomarkers of Chagas cardiomyopathy

Frontiers in Cardiovascular Medicine

Analysis of gene targets associated with cardiac injury yielded results of genes involved in arrhythmia generation, cardiomegaly, and hypertrophy.

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Metabolomics and Biomarkers for Paroxysmal and Persistent Atrial Fibrillation

Journal of the American Heart Association

BackgroundAtrial fibrillation (AF) is the most common type of arrhythmia worldwide and is associated with serious complications. These differential metabolites are potential biomarkers for diagnosis and monitoring of disease course. Journal of the American Heart Association, Ahead of Print.

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Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease

Journal of the American Heart Association

ABSTRACT: Albuminuria, an established biomarker of the progression of chronic kidney disease, is also recognized as a biomarker for the risk of cardiovascular disease. Albuminuria is associated with an increased risk of coronary artery disease, stroke, heart failure, arrhythmias, and microvascular disease.

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SEMA3A as a biomarker of primary ventricular fibrillation complicating STEMI

HeartRhythm

Sympathetic nerve sprouting in the infarct border zone increases transmural dispersion of repolarization, promoting arrhythmias. Overexpression of Semaphorin3A (SEMA3A), a glycoprotein regulating sympathetic nerve growth, limited ventricular arrhythmias in a rat model of MI.1

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A novel degradable PEG superparamagnetic iron oxide capsule coupled with a polyphenolic nano-enzymatic conjugate (PSPM-NE), to treat ROS-driven cardiovascular-diseases, tested in atherosclerosis as a model disease, and hypothesizing autoimmunity as an atheroma's trigger

Frontiers in Cardiovascular Medicine

It is proven challenging managing chronic cardiovascular illnesses like atherosclerosis, arrhythmias, and diverse cardiomyopathies. In this case, because the risk of cardiac events correlates with the QT prolongation rates, the QT or QTc interval prolongation has become an important biomarker to access drug-related cardio-toxicity.