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New wearable cardiac acoustic monitoring technology for evaluation of subclinical leaflet thrombosis after transcatheter aortic valve replacement

Heart BMJ

Background Subclinical leaflet thrombosis (SLT) is a common complication after transcatheter aortic valve replacement (TAVR). Methods This prospective cohort study consecutively enrolled patients with severe symptomatic aortic stenosis who underwent successful TAVR.

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Optimal antithrombotic therapy after transcatheter aortic valve replacement: a comprehensive review

Frontiers in Cardiovascular Medicine

Transcatheter aortic valve replacement (TAVR) has become a leading treatment for aortic stenosis, but managing thromboembolic and bleeding risks post-procedure remains challenging. Subclinical leaflet thrombosis is observed in 10%20% of patients, though its clinical significance remains uncertain.

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Rethinking mechanical heart valves in the aortic position: new paradigms in design and testing

Frontiers in Cardiovascular Medicine

Bileaflet mechanical heart valves (MHV) remain a viable option for aortic valve replacement, particularly for younger patients and patients from low- and middle-income countries and underserved communities. Despite their exceptional durability, MHV recipients are at increased risk of thromboembolic complications.

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JACC Topic of the Week Review Details Pharmacotherapy Algorithm For TAV Thrombosis

American College of Cardiology

For the treatment of transcatheter aortic valve (TAV) thrombosis, both in its more common form of subclinical leaflet thrombosis (SLT) and the rarer clinical valve thrombosis (CVT), pharmacotherapy with vitamin K antagonists (VKA), non-vitamin K oral anticoagulants (NOAC) and an ultraslow, low-dose infusion of thrombolytics should be considered as (..)

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Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening

Circulation: Cardiovascular Interventions

BACKGROUND:Hypoattenuated leaflet thickening (HALT) is believed to reflect leaflet thrombosis; however, no systematic histological examination of HALT has ever been performed. Histological findings in transcatheter aortic valve leaflets were evaluated. MicroCT imaging was used to evaluate HALT in histology.

Aortic 75
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Cancer-associated thoracic aorta arterial thrombosis: case report and review of the literature

Frontiers in Cardiovascular Medicine

BackgroundArterial thrombosis is an uncommon complication in cancer patients, often overshadowed by venous thromboembolic events.

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Abstract 4142998: Optimizing Transcatheter Aortic Valve Design to Mitigate Subclinical Leaflet Thrombosis

Circulation

Introduction:Subclinical leaflet thrombosis is an increasingly recognized complication in patients undergoing transcatheter aortic valve replacement (TAVR). Early clinical data suggested that HALT is more common in supra-annular than intra-annular transcatheter aortic valves (TAVs).