Open Heart

MARCH 8, 2024

Purpose The main objective of this study was to develop two-dimensional (2D) phase contrast (PC) methods to quantify the helicity and vorticity of blood flow in the aortic root. A PC through-plane generated by 4D flow data was treated as a 2D PC plane and compared with the original 4D flow.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Aortic Biomarkers Heart Failure 52

European Journal of Heart Failure

MARCH 19, 2025

Semaglutide reduces late sodium current (I Na ) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end-stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Stenosis Aortic 40

DAIC

FEBRUARY 29, 2024

24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m.

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

European Journal of Heart Failure

DECEMBER 13, 2023

Venn diagram highlighting the main similarities and differences between heart failure with preserved ejection fraction (HFpEF) and aortic stenosis with preserved ejection fraction (ASpEF). HFpEF and ASpEF patients showed similar demographic distribution and biohumoral profiles.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Stenosis Heart Failure Aortic valve 40

Open Heart

JANUARY 8, 2024

Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines.

Aortic valve 98

Aortic valve Aortic Preserved Ejection Fraction Stenosis 98

Heart BMJ

NOVEMBER 27, 2023

Objective To characterise the mechanics responsible for the reduced ejection fraction (rEF) in high-gradient severe aortic stenosis (AS). Methods 21 patients with high-gradient severe AS (aortic valve area (AVA) <1.0 mm Hg/mL; p=0.05), driven by higher degrees of valvular stenosis (valve area 0.46

Stenosis 40

Stenosis Aortic Preserved Ejection Fraction Aortic valve 40

Cardiology Update

APRIL 9, 2024

SMART 4 ( NCT04722250 ) studied patients with severe aortic stenosis and a small aortic annulus who underwent transcatheter aortic valve replacement (TAVR). STEP-HFpEF DM 5 ( NCT04916470 ) explored the effects of semaglutide in obesity-related HF with preserved ejection fraction (HFpEF) and type 2 diabetes.

Angina 52

Angina Myocardial Infarction Aortic valve Coronary Artery Disease 52