Aortic and Preserved Ejection Fraction

Pulse pressure and aortic valve peak velocity and incident heart failure after myocardial infarction: a cohort study

Heart BMJ

MARCH 26, 2025

Background Heart failure with preserved ejection fraction is a recognised outcome in patients with myocardial infarction, although heart failure with reduced ejection fraction is more common. fold higher risk of heart failure with preserved ejection fraction (95% CI 1.30 m/s had a 2.10-fold

Aortic valve

Aortic valve Myocardial Infarction Preserved Ejection Fraction Heart Failure

Heart Failure With Preserved Ejection Fraction Phenotype Is Associated With Early Symptom Onset in Aortic Stenosis and Residual Symptoms After Transcatheter Aortic Valve Implantation

Journal of the American Heart Association

APRIL 16, 2025

BackgroundAortic stenosis can lead to cardiac adaptations and symptoms similar to heart failure with preserved ejection fraction. Methods and ResultsThis retrospective cohort study included 469 patients with moderate aortic stenosis. versus 4.4 m/s in patients with a low H2FPEF score (P<0.001).

Preserved Ejection Fraction

Preserved Ejection Fraction Aortic valve Aortic Heart Failure

Pulse pressure and aortic valve peak velocity as new predictors of heart failure in patients post-myocardial infarction

Heart BMJ

MARCH 26, 2025

1 Left ventricular ejection fraction (LVEF) is a crucial parameter in HF assessment and management, although the differences in mortality are little different between HF with LVEF≥50% or HF with preserved ejection fraction (HFpEF) in patients with post-MI compared with HF with LVEF≤40% or HF with reduced ejection fraction (HFrEF).

Myocardial Infarction

Myocardial Infarction Preserved Ejection Fraction Heart Failure Aortic valve

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Clinical relevance of aortic conduit and reservoir function

Open Heart

AUGUST 19, 2024

Background Aortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR). Methods Twenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (HFpEF) were recruited.

Aortic

Aortic Preserved Ejection Fraction Heart Failure Stroke

Validation of 2D flow MRI for helical and vortical flows

Open Heart

MARCH 8, 2024

Purpose The main objective of this study was to develop two-dimensional (2D) phase contrast (PC) methods to quantify the helicity and vorticity of blood flow in the aortic root. A PC through-plane generated by 4D flow data was treated as a 2D PC plane and compared with the original 4D flow.

Preserved Ejection Fraction

Preserved Ejection Fraction Aortic Biomarkers Heart Failure

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

FEBRUARY 29, 2024

24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m.

Aortic valve

Aortic valve Myocardial Infarction Aortic Blood Pressure

Cardioprotective effects of semaglutide on isolated human ventricular myocardium

European Journal of Heart Failure

MARCH 19, 2025

Semaglutide reduces late sodium current (I Na ) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end-stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients. However, the exact mechanisms underlying its cardioprotective actions remain unclear.

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Stenosis Aortic

Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: A specific phenotype of heart failure with preserved ejection fraction?

European Journal of Heart Failure

DECEMBER 13, 2023

Venn diagram highlighting the main similarities and differences between heart failure with preserved ejection fraction (HFpEF) and aortic stenosis with preserved ejection fraction (ASpEF). HFpEF and ASpEF patients showed similar demographic distribution and biohumoral profiles.

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Stenosis Aortic valve

Systematic review and meta-analysis of early aortic valve replacement versus conservative therapy in patients with asymptomatic aortic valve stenosis with preserved left ventricle systolic function

Open Heart

JANUARY 8, 2024

Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines.

Aortic valve

Aortic valve Aortic Preserved Ejection Fraction Stenosis

Exploring the mechanisms responsible for reduced systolic function in high-gradient aortic stenosis

Heart BMJ

NOVEMBER 27, 2023

Objective To characterise the mechanics responsible for the reduced ejection fraction (rEF) in high-gradient severe aortic stenosis (AS). Methods 21 patients with high-gradient severe AS (aortic valve area (AVA) <1.0 cm 2 and mean gradient (MG) >40 mm Hg) were included.

Stenosis

Stenosis Aortic Preserved Ejection Fraction Aortic valve

Highlights of ACC 2024

Cardiology Update

APRIL 9, 2024

SMART 4 ( NCT04722250 ) studied patients with severe aortic stenosis and a small aortic annulus who underwent transcatheter aortic valve replacement (TAVR). STEP-HFpEF DM 5 ( NCT04916470 ) explored the effects of semaglutide in obesity-related HF with preserved ejection fraction (HFpEF) and type 2 diabetes.

Angina

Angina Myocardial Infarction Aortic valve Coronary Artery Disease

5 Most-Cited Takeaways From the 19th Annual Cardiometabolic Health Congress (CMHC)

Cardiometabolic Health Congress

NOVEMBER 14, 2024

Key Takeaways: Greater Weight Loss, Greater Benefit : Achieving 2-5% weight loss yields metabolic improvements, while over 15% weight loss significantly reduces obesity-related complications like hypertension, NAFLD, and heart failure with preserved ejection fraction (HFpEF).

CME

CME Obesity Heart Failure Biomarkers

Cardiovascular Update

Pulse pressure and aortic valve peak velocity and incident heart failure after myocardial infarction: a cohort study

Heart Failure With Preserved Ejection Fraction Phenotype Is Associated With Early Symptom Onset in Aortic Stenosis and Residual Symptoms After Transcatheter Aortic Valve Implantation

Pulse pressure and aortic valve peak velocity as new predictors of heart failure in patients post-myocardial infarction

Webinars

Clinical relevance of aortic conduit and reservoir function

Validation of 2D flow MRI for helical and vortical flows

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

Cardioprotective effects of semaglutide on isolated human ventricular myocardium

Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: A specific phenotype of heart failure with preserved ejection fraction?

Systematic review and meta-analysis of early aortic valve replacement versus conservative therapy in patients with asymptomatic aortic valve stenosis with preserved left ventricle systolic function

Exploring the mechanisms responsible for reduced systolic function in high-gradient aortic stenosis

Highlights of ACC 2024

5 Most-Cited Takeaways From the 19th Annual Cardiometabolic Health Congress (CMHC)

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