Journal of the American Heart Association

MARCH 13, 2025

BackgroundMean aortic pressure (MAP) plays a pivotal role in both cardiovascular dynamics and the noninvasive estimation of systolic aortic pressure. MAP can be estimated by adding a fraction of the pulse pressure (PP) to the diastolic aortic pressure, known as the form factor (FF=100[MAPdiastolic aortic pressure]/PP).

Aortic 40

Aortic Hypertension 40

Open Heart

JANUARY 21, 2025

Background Aortic coarctation (CoA) is a congenital anomaly leading to upper-body hypertension and lower-body hypotension. Despite surgical or interventional treatment, arterial hypertension may develop and contribute to morbidity and mortality. years, with all patients having undergone previous aortic surgery or intervention.

Aortic 52

Aortic Blood Pressure Hypertension Angioplasty 52

Frontiers in Cardiovascular Medicine

FEBRUARY 13, 2025

Myh11R247C/R247C aortas have aberrant smooth muscle contractile unit-elastin connections by transmission electron microscopy, along with increased focal adhesion signaling at baseline, which further increases with hypertension.ConclusionGene-environment interactions trigger aortic dissections in Myh11R247C/R247C mice.

Aortic 40

Aortic Hypertension Blood Pressure Diet 40

Frontiers in Cardiovascular Medicine

JULY 11, 2024

The incidence of aortic dissection (AD) is steadily increasing, driven by the rising prevalence of chronic conditions such as hypertension and the global aging of the population. Oxidative stress emerges as a pivotal pathophysiological mechanism contributing to the progression of AD.

Aortic 52

Aortic Hypertension 52

Open Heart

OCTOBER 19, 2022

Objective A novel artificial intelligence-based phenotyping approach to stratify patients with severe aortic stenosis (AS) prior to transcatheter aortic valve replacement (TAVR) has been proposed, based on echocardiographic and haemodynamic data.

Aortic valve 52

Aortic valve Aortic Stenosis TAVR 52

Circulation

NOVEMBER 11, 2024

Partial- or total loss of Sca-1 expression exacerbated aortic GFP+CD31-CD45-cell expansion, compared to Sca1GFP [Sca1KI-/-32±7-fold change of vehiclevs.Sca1KI+/-39±9vs.Sca1GFP 5±1; n=11-13/group; p<0.0001], suggesting disinhibited progenitor responses. Partial- or total loss of Sca-1 worsened aortic dilation [Sca1KI-/-1.25±0.06

Aortic 40

Aortic Hypertension Aneurysm Circulation 40

Frontiers in Cardiovascular Medicine

JANUARY 22, 2024

Introduction Compared with first-line antihypertensives, beta-blockers (BB) have been reported to lower the central aortic blood pressure suboptimally and are associated with increased stroke risk. This observation has not been investigated in hypertensives of African ancestry. 3.00; P < 0.001) in hypertensive Africans.

Blood Pressure 64

Blood Pressure Hypertension Myocardial Infarction Cardiovascular Disease 64

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

In the present case, a 76-year-old hypertensive woman was admitted with dizziness and diagnosed with an unruptured bronchial artery aneurysm, which was treated by transcatheter arterial embolization and aortic stent-graft. However, conventional surgical and transcatheter arterial embolization treatments are less effective.

Embolism 59

Embolism Aneurysm Stent Stents 59

Hypertension Journal

OCTOBER 6, 2023

Hypertension, Volume 80, Issue 12 , Page 2650-2664, December 1, 2023. BACKGROUND:Inflammation plays a critical role in the development of hypertension and vascular remodeling. Moreover, RvE1 reduced the aortic infiltration of macrophages and T cells, which was also reversed by ChemR23 knockdown.

Hypertension 40

Hypertension Aortic Blood Pressure 40

Hypertension Journal

FEBRUARY 5, 2025

Hypertension, Ahead of Print. BACKGROUND:The pathophysiology of familial thoracic aortic aneurysm and dissection (TAAD) is linked to genetic variants that affect aortic components. These findings establish a genetic link between systolic hypertension and TAAD.

Aneurysm 40

Aneurysm Aortic Hypertension Risk Factors 40

Journal of the American Heart Association

JANUARY 9, 2024

BackgroundProtruding aortic plaque is known to be associated with an increased risk for future cardiac and cerebrovascular events. Coronary plaque characteristics were compared to evaluate coronary plaque vulnerability in patients with protruding aortic plaque on computed tomography angiography.

Plaque 45

Plaque Aortic Myocardial Infarction Kidney Disease 45

Frontiers in Cardiovascular Medicine

JULY 21, 2024

BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between the genetic predisposition to type 2 diabetes mellitus (T2DM) and aortic dissection (AD), and to assess associations with genetically predicted glycemic traits. For AD data, FinnGen Release 10 was used, including 967 cases and 381,977 controls.

Genetic predisposition 59

Genetic predisposition Diabetes Aortic Coronary Artery Disease 59

Journal of the American Heart Association

FEBRUARY 26, 2025

BackgroundAbdominal aortic aneurysm (AAA) is a severe aortic disease for which no pharmacological interventions have yet been developed. Journal of the American Heart Association, Ahead of Print. Colocalization analysis pinpointed 13 proteins with strong evidence of colocalization with AAA.

Aneurysm 40

Aneurysm Risk Factors Aortic Obesity 40

Heart BMJ

DECEMBER 15, 2023

Objective The European Society of Cardiology guidelines have recently defined new cut-offs for pulmonary hypertension (PH) and pulmonary vasculature resistance (PVR; median pulmonary artery pressure (mPAP) >20 instead of 25 mm Hg and PVR >2 instead of 3 Wood unit).

Aortic valve 40

Aortic valve Pulmonary Hypertension Aortic 40

Hypertension Journal

FEBRUARY 6, 2024

Hypertension, Ahead of Print. Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease.

Aortic 40

Aortic Atherosclerosis Pharmacology Aneurysm 40

Hypertension Journal

JANUARY 4, 2024

Hypertension, Ahead of Print. BACKGROUND:Hypertension is one of the main risk factors for dementia and cognitive impairment.METHODS:We used the model of transverse aortic constriction to induce chronic pressure overload in mice. We characterized brain injury by advanced translational applications of magnetic resonance imaging.

Hypertension 49

Hypertension Dementia Risk Factors Aortic 49

Hypertension Journal

JANUARY 19, 2024

Hypertension, Ahead of Print. Cell composition analysis showed that vascular injury and hypertension independently induced distinct aortic cell phenotypic alterations including immune cells, endothelial cells (ECs), and smooth muscle cells.

Hypertension 40

Hypertension Blood Pressure Angioplasty Aortic 40

Dr. Smith's ECG Blog

MAY 20, 2024

A 63 year old man with a history of hypertension, hyperlipidemia, prediabetes, and a family history of CAD developed chest pain, shortness of breath, and diaphoresis after consuming a large meal at noon. He called EMS, who arrived on scene about two hours after the onset of pain to find him hypertensive at 220 systolic.

Chest Pain 126

Chest Pain Blood Pressure Ischemia STEMI 126

Heart BMJ

FEBRUARY 12, 2024

The patient had pregnancy-induced hypertension and hypothyroidism and was treated accordingly. The patient was managed medically and was referred to us in view of worsening symptoms with severe left ventricular dysfunction and moderate aortic regurgitation. The renal and carotid Doppler tests were normal.

Coronary Angiogram 75

Coronary Angiogram Aortic valve Echocardiogram Aortic 75

Circulation: Cardiovascular Quality & Outcomes

MARCH 28, 2025

Among all covariates, claims algorithms for covariates had sensitivities 85% for identifying diabetes, atrial flutter/fibrillation, and hypertension in MA and FFS. The kappa was higher in MA versus FFS for diabetes (P=0.03) and hypertension (P=0.025) but was lower in myocardial infarction (P&lt;0.0001).

Medicare 40

Medicare Aortic valve Atrial Flutter Aortic 40

Becker's Hospital Review - Cardiology

JULY 11, 2024

Pulmonary hypertension patients who undergo transcatheter aortic valve replacement are at a higher risk for mortality than those without pulmonary hypertension, according to a recent study.

Aortic valve 52

Aortic valve TAVR Pulmonary Hypertension 52

Heart BMJ

DECEMBER 15, 2023

Pulmonary hypertension (PH) is a complex and progressive disorder characterised by elevated pulmonary artery pressure. Transcatheter aortic valve implantation (TAVI) is a minimally invasive surgical procedure that has revolutionised the treatment of severe aortic stenosis (AS).

Aortic valve 40

Aortic valve Pulmonary Aortic Quality of Life 40

Med Page Today

SEPTEMBER 3, 2024

(MedPage Today) -- LONDON -- A set of new European guidelines streamlined recommendations for atrial fibrillation (Afib), chronic coronary disease, peripheral artery disease (PAD) and aortic disease, and hypertension, with an emphasis on shared.

Peripheral Arterial Disease 52

Peripheral Arterial Disease Atrial Fibrillation AFIB Aortic 52

Hypertension Journal

OCTOBER 5, 2023

Hypertension, Volume 80, Issue 12 , Page 2627-2640, December 1, 2023. BACKGROUND:Endothelial dysfunction plays a crucial role in aortic remodeling. Aerobic glycolysis and endothelial-to-mesenchymal transition (EndoMT) have, respectively, been suggested to contribute to endothelial dysfunction in many cardiovascular diseases.

Aortic 40

Aortic Cardiovascular Disease Hypertension 40

Circulation

NOVEMBER 11, 2024

Background:Primary pulmonary arterial hypertension (PAH) is a disease affecting young subjects. Circulation, Volume 150, Issue Suppl_1 , Page A4117657-A4117657, November 12, 2024. It has very poor prognosis and optimal treatment is not available. Litter-mate controls (7 WT and 13 KO) were subjected to normoxia (room air, 21% O2).

Pulmonary 40

Pulmonary Hypertension Blood Pressure Pharmacology 40

Dr. Smith's ECG Blog

MAY 5, 2024

The provider had sent the patient for an aortic dissection scan which had shown extremely heavy calcification of the LAD.

EKG Technician 124

EKG Technician Chest Pain Blog STEMI 124

Hypertension Journal

FEBRUARY 23, 2024

Hypertension, Ahead of Print. BACKGROUND:Wave separation analysis enables individualized evaluation of the aortic pulse wave components. Previous studies focused on the pressure height with overall positive but differing results.

Aortic 45

Aortic Hypertension 45

European Journal of Heart Failure

JANUARY 21, 2024

Bar plots: in red, patients with low flow-low gradient (LF-LG) aortic stenosis; in blue, patients with normal flow-high gradient (HG) aortic stenosis; in black: controls. Aim Cardiac remodelling plays a major role in the prognosis of patients with aortic stenosis (AS) and could impact the benefits of aortic valve replacement.

Stenosis 40

Stenosis Aortic Aortic valve Coronary Artery Disease 40

Circulation: Cardiovascular Imaging

OCTOBER 14, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 10 , Page e000085, October 1, 2024.

Cardiovascular Imaging 40

Cardiovascular Imaging Stenosis Hypertension Aortic 40

Circulation: Cardiovascular Imaging

AUGUST 19, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 8 , Page e017266, August 1, 2024.

Cardiovascular Imaging 40

Cardiovascular Imaging Stenosis Hypertension Aortic 40

DAIC

FEBRUARY 29, 2024

24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m.

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Hypertension Journal

JANUARY 16, 2025

Hypertension, Ahead of Print. BACKGROUND:Adrenomedullin 2 (AM2) plays critical roles in regulating blood pressure and fluid balance. Comprehensive cardiac morphology, function, histology, and transcriptome/metabolome analyses were conducted.

Aortic 45

Aortic Blood Pressure Heart Failure Hypertension 45

Hypertension Journal

JANUARY 29, 2025

Hypertension, Ahead of Print. BACKGROUND:Recent studies show that hyperactivation of mTOR (mammalian target of rapamycin) signaling plays a causal role in the development of thoracic aortic aneurysm and dissection. Echocardiography was performed to monitor the growth of the aortic root and ascending aorta.

Aneurysm 45

Aneurysm Aortic Hypertension 45

DAIC

MARCH 10, 2025

Among Medtronic's Structural Heart and Aortic key data milestones,Dr. The presentation addressed the two-year results of the SMall Annuli Randomized To Evolut or SAPIENTrial, which evaluated a valve performance in individuals with aortic stenosiswith small aortic annulusin patients treated with either EvolutTAVR platform or SAPIENplatform.

Blood Pressure 52

Blood Pressure Aortic Medicare Hypertension 52

Ken Grauer, MD

JUNE 6, 2023

I've previously discussed the interesting correlation of a qR pattern in lead V1 in patients with RVH — as strongly suggesting associated pulmonary hypertension ( See ECG Blog #234 and Blog #248 ). The plan was to proceed as soon as possible with aortic valve replacement. Then there is the significant ST elevation we see in lead V1.

Blog 78

Blog Pulmonary Hypertension Aortic 78

All About Cardiovascular System and Disorders

MARCH 18, 2024

This is the aortic knuckle. It can occur in severe pulmonary hypertension, there can be right atrial enlargement, as the severe hypertrophy of the right ventricle causes elevation of right ventricular end diastolic pressure, and later on right atrial enlargement. It is not visible here. And you are seeing some end on views probably.

VSD 52

VSD Pulmonary Hypertension Aortic 52

Open Heart

SEPTEMBER 7, 2022

Only the transfemoral transcatheter aortic valve replacement (TAVR) approach was associated with the prevention of POAF and was supported by convincing evidence from meta-analyses of observational data. Two other associations provided highly suggestive evidence, including preoperative hypertension and neutrophil/lymphocyte ratio.

Atrial Fibrillation 52

Atrial Fibrillation Aortic valve TAVR Aortic 52