American College of Cardiology

MARCH 27, 2024

In this week’s View, Dr. Eagle looks at sacubitril/valsartan in patients hospitalized with decompensated heart failure, then examines the prevalence and outcomes of patients with discordant high gradient aortic stenosis.

Heart Failure 56

Heart Failure Stenosis Aortic Tricuspid 56

DAIC

JANUARY 29, 2024

Getty Images milla1cf Mon, 01/29/2024 - 14:24 January 29, 2024 — Despite national guidelines recommending surgical aortic valve replacement (SAVR) for patients under age 65 with severe aortic stenosis , many hospitals are still opting for a nonsurgical approach in patients under 60—possibly with poorer survival rates.

Aortic valve 111

Aortic valve TAVR Aortic Outcomes 111

American College of Cardiology

OCTOBER 28, 2024

The goal of the TAVR UNLOAD trial was to evaluate transcatheter aortic valve replacement (TAVR) compared with clinical surveillance among patients with chronic systolic heart failure and moderate aortic stenosis (stage B aortic stenosis).

Aortic valve 48

Aortic valve Heart Failure Aortic TAVR 48

European Journal of Heart Failure

FEBRUARY 26, 2025

Proposed approach for clinical management and therapeutic optimization in patients with heart failure with reduced ejection fraction and low blood pressure. Low blood pressure with major or mild symptoms. **SBP SBP <80mmHg or symptomatic low BP or asymptomatic low BP.

Blood Pressure 58

Blood Pressure Heart Failure Aortic valve TAVR 58

Circulation: Cardiovascular Imaging

MARCH 21, 2025

BACKGROUND:Patients with paradoxical low-flow, low-gradient severe aortic stenosis exhibit low transvalvular flow rate (Q), while maintaining preserved left ventricular ejection fraction. Over a follow-up of up to 5 years, severe MR correlated with higher all-cause mortality (P=0.02) and aortic valve replacement rates (P=0.012).

Stenosis 40

Stenosis Aortic Aortic valve Bicuspid/Mitral 40

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Background Closure of paravalvular leak (PVL) regurgitation after self-expandable (SE) transcatheter aortic valve implantation (TAVI) may be more challenging than after balloon-expandable (BE) valve implantation. The patient was deemed to be at prohibitive surgical risk and a catheter-based PVL closure procedure was planned.

Aortic valve 111

Aortic valve Aortic Atrial Fibrillation Heart Failure 111

European Journal of Heart Failure

JANUARY 31, 2024

TAVR in heart failure. ABSTRACT Patients with severe aortic stenosis (AS) may develop heart failure (HF), the presence of which has traditionally been deemed as a final stage in AS progression with poor outcomes.

Aortic valve 40

Aortic valve Heart Failure Aortic TAVR 40

European Journal of Heart Failure

DECEMBER 11, 2024

Abstract Worldwide, valvular heart disease (VHD) is a common cause of hospitalization for acute heart failure. In acute heart failure caused by VHD, symptoms result from rapid haemodynamic changes and subsequent decline in cardiac function, and if left untreated, leads to acute decompensation and cardiogenic shock.

Cardiogenic Shock 68

Cardiogenic Shock Heart Disease Heart Failure Bicuspid/Mitral 68

HeartRhythm

AUGUST 31, 2024

Aortic stenosis (AS) is an increasingly common valvular disease and, if left untreated, can lead to heart failure (HF).

Stenosis 40

Stenosis Aortic Electrocardiogram Heart Failure 40

NEJM Journal Watch - Cardiology

MARCH 18, 2025

A small randomized study failed to show a benefit of TAVR in this population.

TAVR 40

TAVR Heart Failure Stenosis Aortic 40

Open Heart

DECEMBER 2, 2023

Objective The association between a combined anaemia and renal failure index and 1-year prognosis of patients undergoing transcatheter aortic valve implantation (TAVI) is unexplored. The primary clinical outcome measure was all-cause mortality and heart failure hospitalisation 1 year after TAVI. Cut-off values were 10.1

Aortic valve 52

Aortic valve Aortic Heart Failure Stenosis 52

Circulation: Cardiovascular Interventions

APRIL 7, 2025

BACKGROUND:The extent of cardiac damage has been shown to be associated with increased mortality, repeat hospitalization, and decreased quality of life after aortic valve replacement (AVR). Patients were categorized into 5 groups (stages 04) based on their stage of cardiac damage in the year before AVR.

Aortic valve 40

Aortic valve Aortic Heart Failure Quality of Life 40

Open Heart

SEPTEMBER 18, 2024

Backgrounds Permanent pacemaker implantation (PPMI) is one of the greatest disadvantages of transcatheter aortic valve implantation (TAVI). Methods We retrospectively analysed data from 745 consecutive patients who underwent TAVI for severe aortic stenosis from November 2013 to July 2022. vs 9.1%±9.7%; p=0.035).

Aortic valve 52

Aortic valve Pacemaker Aortic Heart Failure 52

Cardiovascular Diabetology

FEBRUARY 15, 2024

Stress hyperglycemia ratio (SHR) has recently been recognized as a novel biomarker that accurately reflects acute hyperglycemia status and is associated with poor prognosis of heart failure. We evaluated the r.

Aortic valve 52

Aortic valve Aortic Biomarkers Heart Failure 52

DAIC

AUGUST 27, 2024

We know that structural heart disease and heart failure are the leading causes of hospitalization and morbidity in the U.S. Standalone performance for significant major valve disease pathology (aortic stenosis and regurgitation and mitral and tricuspid regurgitation) had a 93 percent sensitivity and 93 percent specificity.

Ultrasound 98

Ultrasound Tricuspid Bicuspid/Mitral Aortic 98

European Journal of Heart Failure

JANUARY 21, 2024

Bar plots: in red, patients with low flow-low gradient (LF-LG) aortic stenosis; in blue, patients with normal flow-high gradient (HG) aortic stenosis; in black: controls. Main findings of the study. p  < 0.05 for HG and LF-LG vs. control; § p  < 0.05 for LF-LG vs. . # p  < 0.05 for LF-LG vs. HG.

Stenosis 40

Stenosis Aortic Aortic valve Coronary Artery Disease 40

DAIC

FEBRUARY 29, 2024

24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m.

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

DAIC

FEBRUARY 15, 2024

Advances in Transcatheter Tricuspid Valve Technologies VIDEO: Tricuspid Device Clinical Trial Overview — Interview with Ori Ben-Yehuda, M.D.

Tricuspid 102

Tricuspid Heart Valves Quality of Life Bicuspid/Mitral 102

CardiacWire

JANUARY 24, 2024

CardioSignal has already developed digital biomarkers for AFib and heart failure, while more solutions could be on the way for aortic stenosis, coronary artery disease, and pulmonary artery hypertension.

AFIB 75

AFIB Coronary Artery Disease Biomarkers Heart Failure 75

European Journal of Heart Failure

MARCH 19, 2025

Semaglutide reduces late sodium current (I Na ) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end-stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Stenosis Aortic 40

Dr. Smith's ECG Blog

MAY 20, 2024

The Queen of Hearts disagrees, diagnosing OMI with high confidence: Case Continued: The EKG was not immediately recognized by the emergency provider, who ordered a CT scan to rule out aortic dissection at 1419. Smith comment 2: I frequently see failure to control BP in patients with acute chest pain or acute heart failure.

Chest Pain 126

Chest Pain Blood Pressure Ischemia STEMI 126

ECG Cases

JANUARY 4, 2022

What is the evidence for intra-aortic balloon pumps, percutaneous ventricular assist devices and ECMO in the patient with cardiogenic shock? Which patients with acute heart are safe to send home in general? How useful is the Ottawa Heart Failure Risk Score in aiding in disposition decisions?

Cardiogenic Shock 52

Cardiogenic Shock Heart Failure Aortic Stenosis 52

Open Heart

MARCH 8, 2024

Purpose The main objective of this study was to develop two-dimensional (2D) phase contrast (PC) methods to quantify the helicity and vorticity of blood flow in the aortic root. A PC through-plane generated by 4D flow data was treated as a 2D PC plane and compared with the original 4D flow.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Aortic Biomarkers Heart Failure 52

Dr. Smith's ECG Blog

SEPTEMBER 14, 2014

At that previous visit, he had had some mildly elevated troponins, but mostly had severe heart failure from very poor systolic function and aortic stenosis. During both presentations, the patient was fluid overloaded, and had decompensated heart failure with a very low ejection fraction.

Chest Pain 52

Chest Pain Pacemaker Cardiomyopathy STEMI 52

Dr. Smith's ECG Blog

NOVEMBER 19, 2016

Look at the aortic outflow tract. The diagnostic coronary angiogram identified only minimal coronary artery disease, but there was a severely calcified, ‘immobile’ aortic valve. Aortic angiogram did not reveal aortic dissection. What do you see? Answer below in the still shot.

Ischemia 40

Ischemia Cardiogenic Shock Aortic Stenosis 40

CardiacWire

JUNE 21, 2024

The Takeaway Echocardiography has long been an AI hotspot due to its importance, prevalence, and its challenges with efficiency and variability, but most clinical-level echo AI solutions have focused on heart failure and aortic stenosis so far.

Bicuspid/Mitral 59

Bicuspid/Mitral Research Academic Heart Failure 59

European Journal of Heart Failure

FEBRUARY 19, 2024

Rates of concomitant tricuspid valve (TV) intervention at the time of left-sided heart valve surgery were high at the time of mitral valve surgery (50% when mitral stenosis, 41% when MR). An increase in TR grade was associated with a more severe clinical presentation and a poorer 6-month survival ( p  < 0.0001).

Tricuspid 40

Tricuspid Heart Disease Bicuspid/Mitral Heart Valves 40

Circulation: Heart Failure

NOVEMBER 11, 2024

Circulation: Heart Failure, Ahead of Print. Background:Distinguishing hypertrophic cardiomyopathy (HCM) from other cardiomyopathies with left ventricular hypertrophy (LVH), such as hypertensive LVH, transthyretin amyloid cardiomyopathy (ATTR-CM), and aortic stenosis (AS), is sometimes challenging.

Cardiomyopathy 40

Cardiomyopathy Biomarkers Circulation Hypertension 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

However, CTA head and neck 4 days later demonstrated 90 percent stenosis of the mid left V2 at the C3‐4 level and a 75‐90 percent stenosis of the left mid V2 segment at the C5‐6 level (hard and soft plaque in these areas). He was switched from DAPT to aspirin and warfarin because he was considered a “DAPT failure.”

Stenosis 40

Stenosis Peripheral Arterial Disease Pacemaker Atherosclerosis 40

DAIC

APRIL 5, 2024

New York Valves marks the next iteration of this legacy, featuring three days of transformative research and techniques that will redefine the landscape of structural heart interventions. Transcatheter valve therapy has evolved from a novel treatment for the sickest patients to become the standard of care for many with aortic stenosis.

Research 52

Research Heart Disease Best Practices Education 52

DAIC

APRIL 5, 2024

New York Valves marks the next iteration of this legacy, featuring three days of transformative research and techniques that will redefine the landscape of structural heart interventions. Transcatheter valve therapy has evolved from a novel treatment for the sickest patients to become the standard of care for many with aortic stenosis.

Heart Disease 52

Heart Disease Best Practices Education Tricuspid 52

Dr. Smith's ECG Blog

DECEMBER 14, 2016

There was a normal creatinine and no evidence of heart failure and no other reason for chronic injury, so it must be acute. The patient had no hypertension, no tachycardia, a normal hemoglobin, no drug use, no hypotension/shock, no murmur of aortic stenosis. The pain was unrelieved. What do you want to do?

Chest Pain 52

Chest Pain STEMI Aortic Pulmonary 52

EMS 12-Lead

MAY 20, 2022

There is ventricular hypertrophy in the absence of abnormal loading conditions, such as aortic stenosis, or hypertension, for example – of which the most common variant is Asymmetric Septal Hypertrophy. As a brief review, HCM is a genetically inherited disorder that produces structural disarray in the myocardial cells.

Cardiomyopathy 52

Cardiomyopathy Ischemia STEMI Coronary Angiogram 52

DAIC

MARCH 28, 2024

milla1cf Thu, 03/28/2024 - 07:30 March 28, 2024 — Medtronic plc, a global leader in healthcare technology, announced that the United States Food and Drug Administration ( FDA ) has approved the Evolut FX+ transcatheter aortic valve replacement (TAVR) system for the treatment of symptomatic severe aortic stenosis. Circulation.

TAVR 111

TAVR Stenosis Aortic Aortic valve 111

Journal of the American Heart Association

JANUARY 16, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundThe coexistence of transthyretin cardiac amyloidosis (ATTRCA) and aortic stenosis (AS) is increasingly recognized, but the clinical consequences are unclear. P=0.003) but not heart failure hospitalization (HR, 1.1 [95% 95% CI, 1.11.4];P&lt;0.0001)

Aortic 73

Aortic Aortic valve Stenosis Outcomes 73

Open Heart

JANUARY 8, 2024

Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines.

Aortic valve 98

Aortic valve Aortic Preserved Ejection Fraction Stenosis 98

DAIC

APRIL 23, 2024

This next-generation surgical aortic tissue valve is designed to facilitate ease of use at implant and lifetime patient management. It’s an excellent choice for cardiac surgeons and their patients seeking an aortic valve solution that can be fit for the future, right from the start. Presented at Heart Valve Society 2024, Boston, MA.

Aortic valve 111

Aortic valve Aortic Innovation Cardiothoracic 111