CardiacWire

JULY 28, 2024

Edwards Lifesciences is going all-in on structural heart and heart failure, acquiring aortic valve-maker JenaValve Technology and implantable heart failure monitor company Endotronix for $1.2B and up to $445M in milestone payments.

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Heart Failure Aortic TAVR Critical Care 59

Open Heart

JANUARY 8, 2024

Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines.

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Aortic valve Aortic Preserved Ejection Fraction Stenosis 98

DAIC

JUNE 13, 2024

Food and Drug Administration ( FDA ) announced that Teleflex , and their subsidiary Arrow International , are recalling the Arrow FiberOptix Intra-Aortic Balloon Catheter Kit and Arrow UltraFlex Intra-Aortic Balloon Catheter Kits after finding that a manufacturing error may cause the catheter’s balloon to become overtwisted.

Aortic 115

Aortic Blood Pressure Ischemia Heart Failure 115

Frontiers in Cardiovascular Medicine

JANUARY 22, 2025

IntroductionThe objective of this study was to examine the impact of ventricular assist device support as a bridge to heart transplantation in children with end-stage heart failure. Early primary-graft-failure was 10% in group 1 and 13% in group 2.

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Heart Transplant Transplant Pediatrics Heart Failure 52

DAIC

MARCH 28, 2024

milla1cf Thu, 03/28/2024 - 07:30 March 28, 2024 — Medtronic plc, a global leader in healthcare technology, announced that the United States Food and Drug Administration ( FDA ) has approved the Evolut FX+ transcatheter aortic valve replacement (TAVR) system for the treatment of symptomatic severe aortic stenosis. Aortic stenosis.

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TAVR Stenosis Aortic Aortic valve 111

American College of Cardiology

JUNE 18, 2024

In this week's View, Dr. Eagle looks at secular trends of incidence and outcomes in severe aortic stenosis. He then examines titration of medications after acute heart failure.

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Heart Failure Stenosis Aortic TAVR 48

Medical Xpress - Cardiology

OCTOBER 29, 2024

Findings from the TAVR UNLOAD study found limited benefits of transcatheter aortic valve replacement (TAVR) in the treatment of heart failure (HF) with reduced ejection fraction (HFrEF) and moderate aortic stenosis (AS).

Aortic valve 45

Aortic valve Aortic Heart Failure Stenosis 45

DAIC

MARCH 4, 2025

The Most Common Form of HVD One of the most prevalent and serious forms of heart valve disease is aortic stenosis (AS), a condition characterized by the narrowing of the aortic valve opening, which affects approximately 5% of adults over 65a number expected to more than double by 2050.

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Heart Valves Aortic valve Aortic Stenosis 52

DAIC

JANUARY 29, 2024

Getty Images milla1cf Mon, 01/29/2024 - 14:24 January 29, 2024 — Despite national guidelines recommending surgical aortic valve replacement (SAVR) for patients under age 65 with severe aortic stenosis , many hospitals are still opting for a nonsurgical approach in patients under 60—possibly with poorer survival rates.

Aortic valve 111

Aortic valve TAVR Aortic Outcomes 111

Frontiers in Cardiovascular Medicine

MARCH 3, 2024

Background Objective tools to define the optimal time for referral for advanced therapies and to help guide escalation and de-escalation of support can improve management decisions and outcomes for patients with advanced heart failure. Results Approximately 1010 discrete heart failure scenarios were modeled.

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Heart Failure Cardiogenic Shock Physiology Transplant 85

American College of Cardiology

DECEMBER 17, 2024

The following are key points to remember from a review on aortic stenosis (AS), heart failure (HF), and aortic valve replacement (AVR).

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Aortic valve Heart Failure Aortic Stenosis 40

Frontiers in Cardiovascular Medicine

MARCH 28, 2025

All statistical analyses were rigorously executed in R software.ResultsOur findings identified causal relationships between 15 metabolites and cardiovascular disease.

Cardiovascular Disease 52

Cardiovascular Disease Atrial Fibrillation Aneurysm Heart Failure 52

Journal of the American Heart Association

JANUARY 16, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundThe coexistence of transthyretin cardiac amyloidosis (ATTRCA) and aortic stenosis (AS) is increasingly recognized, but the clinical consequences are unclear. P=0.003) but not heart failure hospitalization (HR, 1.1 [95% 95% CI, 1.11.4];P<0.0001)

Aortic 73

Aortic Aortic valve Stenosis Outcomes 73

European Journal of Heart Failure

FEBRUARY 26, 2025

Proposed approach for clinical management and therapeutic optimization in patients with heart failure with reduced ejection fraction and low blood pressure. Low blood pressure with major or mild symptoms. **SBP SBP <80mmHg or symptomatic low BP or asymptomatic low BP.

Blood Pressure 58

Blood Pressure Heart Failure Aortic valve TAVR 58

American College of Cardiology

OCTOBER 28, 2024

The goal of the TAVR UNLOAD trial was to evaluate transcatheter aortic valve replacement (TAVR) compared with clinical surveillance among patients with chronic systolic heart failure and moderate aortic stenosis (stage B aortic stenosis).

Aortic valve 43

Aortic valve Heart Failure Aortic TAVR 43

European Journal of Heart Failure

JANUARY 31, 2024

TAVR in heart failure. ABSTRACT Patients with severe aortic stenosis (AS) may develop heart failure (HF), the presence of which has traditionally been deemed as a final stage in AS progression with poor outcomes.

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Aortic valve Heart Failure Aortic TAVR 40

American College of Cardiology

MARCH 31, 2025

The goal of the Altshock-2 trial was to evaluate the effect of early intra-aortic balloon pump (IABP) use vs. standard care on 60-day survival or successful bridging to heart replacement therapies (HRT) in patients with heart failurecardiogenic shock (HF-CS).

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Cardiogenic Shock Aortic Heart Failure Article 53

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Background Closure of paravalvular leak (PVL) regurgitation after self-expandable (SE) transcatheter aortic valve implantation (TAVI) may be more challenging than after balloon-expandable (BE) valve implantation. The patient was deemed to be at prohibitive surgical risk and a catheter-based PVL closure procedure was planned.

Aortic valve 111

Aortic valve Aortic Atrial Fibrillation Heart Failure 111

Frontiers in Cardiovascular Medicine

FEBRUARY 29, 2024

Background High pulse pressure (PP) and aortic root diameter (AoD) are hallmarks of arterial stiffness or vascular aging and they are considered as risk factors for age-related cardiovascular disease, including heart failure (HF). However, the relationship between PP and AoD in patients with heart failure (HF) is uncertain.

Heart Failure 53

Heart Failure Aortic BMI Risk Factors 53

American College of Cardiology

MARCH 27, 2024

In this week’s View, Dr. Eagle looks at sacubitril/valsartan in patients hospitalized with decompensated heart failure, then examines the prevalence and outcomes of patients with discordant high gradient aortic stenosis.

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Heart Failure Stenosis Aortic Tricuspid 48

DAIC

FEBRUARY 22, 2024

Photo courtesy of Mount Sinai Health System milla1cf Thu, 02/22/2024 - 13:47 February 22, 2024 — Ismail El-Hamamsy , MD, PhD, Director of Aortic Surgery for the Mount Sinai Health System and the Mount Sinai Randall B. The aortic valve controls blood flow from the heart into the aorta, the main artery that feeds blood to most of the body.

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Heart Valves Aortic valve Aortic Sudden Cardiac Death 142

Heart BMJ

JULY 10, 2024

Clinical introduction A woman in her 60s with non-obstructive coronary artery disease, aortic valve replacement and aortic arch repair, chronic diastolic heart failure and paroxysmal atrial fibrillation (AF) and flutter (AFL), presented with 3 days of sustained palpitations that felt similar to prior episodes of AF/AFL.

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Tachycardia Aortic valve Coronary Artery Disease Atrial Fibrillation 102

DAIC

JULY 29, 2024

mtaschetta-millane Mon, 07/29/2024 - 09:02 July 29, 2024 — Edwards Lifesciences announced investments that reflect the company’s deep commitment to advancing patient care through structural heart innovation, addressing large unmet patient needs and supporting sustainable long-term growth. JenaValve presented positive results of its U.S.

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Innovation Aortic valve Aortic CMS 105

HeartRhythm

JANUARY 30, 2025

New-onset persistent left bundle branch block (NOP-LBBB) at discharge after transcatheter aortic valve replacement (TAVR) is frequent but its association with death and hospitalization for heart failure (HHF) remains unclear.

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Aortic valve Heart Failure Aortic TAVR 40

Frontiers in Cardiovascular Medicine

FEBRUARY 25, 2025

Two years ago, the patient suffered from type A aortic dissection. As a result, partial aortic dissection artificial vascular replacement and partial aortic arch artificial vascular replacement were performed.

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Aortic Heart Failure Hospital 52

Open Heart

AUGUST 19, 2024

Background Aortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR). Methods Twenty healthy controls (10 young and 10 age-gender-matched old controls) and 20 patients with heart failure with preserved ejection fraction (HFpEF) were recruited.

Aortic 52

Aortic Preserved Ejection Fraction Heart Failure Stroke 52

European Journal of Heart Failure

DECEMBER 11, 2024

Abstract Worldwide, valvular heart disease (VHD) is a common cause of hospitalization for acute heart failure. In acute heart failure caused by VHD, symptoms result from rapid haemodynamic changes and subsequent decline in cardiac function, and if left untreated, leads to acute decompensation and cardiogenic shock.

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Cardiogenic Shock Heart Disease Heart Failure Bicuspid/Mitral 68

Med Page Today

MARCH 29, 2025

(MedPage Today) -- CHICAGO -- Dapagliflozin (Farxiga) lowered mortality and heart failure worsening in high-risk older adults getting transcatheter aortic valve implantation (TAVI), the DapaTAVI trial showed. In a population with a history of.

Aortic valve 64

Aortic valve Outcomes Heart Failure Aortic 64

Journal of the American Heart Association

JANUARY 31, 2024

The present study sought to test the hypothesis that hypoxia is cardioprotective in left ventricular pressure overload (LVPO)–induced heart failure. The HxTAC model is resistant to cardiac hypertrophy and the development of heart failure.

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Heart Failure Aortic Heart Disease 45

DAIC

APRIL 23, 2024

This next-generation surgical aortic tissue valve is designed to facilitate ease of use at implant and lifetime patient management. It’s an excellent choice for cardiac surgeons and their patients seeking an aortic valve solution that can be fit for the future, right from the start. Presented at Heart Valve Society 2024, Boston, MA.

Aortic valve 111

Aortic valve Aortic Innovation Cardiothoracic 111

Open Heart

DECEMBER 2, 2023

Objective The association between a combined anaemia and renal failure index and 1-year prognosis of patients undergoing transcatheter aortic valve implantation (TAVI) is unexplored. The primary clinical outcome measure was all-cause mortality and heart failure hospitalisation 1 year after TAVI. Cut-off values were 10.1

Aortic valve 52

Aortic valve Aortic Heart Failure Stenosis 52

DAIC

JUNE 13, 2024

This next-generation surgical aortic tissue valve is designed to facilitate ease of use at implant and lifetime patient management. It’s an excellent choice for cardiac surgeons and their patients seeking an aortic valve solution that can be fit for the future, right from the start. Presented at Heart Valve Society 2024, Boston, MA.

Aortic valve 109

Aortic valve Aortic Innovation Cardiothoracic 109

DAIC

SEPTEMBER 4, 2024

1, 2024 — Researchers at UTHealth Houston have identified genetic variants linked to a rare form of bicuspid aortic valve disease that affects young adults and can lead to dangerous and potentially life-threatening aortic complications. tim.hodson Wed, 09/04/2024 - 15:53 Sept.

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Aortic valve Bicuspid/Mitral Aortic Research 52

Circulation: Heart Failure

JANUARY 20, 2025

Circulation: Heart Failure, Ahead of Print. The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock.

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Cardiogenic Shock Heart Failure Circulation Physiology 40

Open Heart

SEPTEMBER 18, 2024

Backgrounds Permanent pacemaker implantation (PPMI) is one of the greatest disadvantages of transcatheter aortic valve implantation (TAVI). Methods We retrospectively analysed data from 745 consecutive patients who underwent TAVI for severe aortic stenosis from November 2013 to July 2022. vs 9.1%±9.7%; p=0.035).

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Aortic valve Pacemaker Aortic Heart Failure 52

Circulation: Cardiovascular Imaging

MARCH 21, 2025

BACKGROUND:Patients with paradoxical low-flow, low-gradient severe aortic stenosis exhibit low transvalvular flow rate (Q), while maintaining preserved left ventricular ejection fraction. Over a follow-up of up to 5 years, severe MR correlated with higher all-cause mortality (P=0.02) and aortic valve replacement rates (P=0.012).

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Stenosis Aortic Aortic valve Bicuspid/Mitral 40

DAIC

JANUARY 5, 2024

Joint Statement on Aortic Valve Replacement in Low-Risk Patients Issued by Society of Thoracic Surgeons and European Association for Cardiothoracic Surgeons 6. STOP-CA Clinical Trial Finds Statins Lower Rate of Heart Decline in Lymphoma Patients, Late-Breaking ACC23 Clinical Trial Reports 7.

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Atrial Fibrillation Aortic valve Cardiothoracic Interventional Cardiology 105