Journal of the American Heart Association

FEBRUARY 26, 2025

BackgroundCardiac fibrosis is common in patients with severe aortic stenosis and an independent predictor of death. Combined with highsensitivity cardiac troponin T, circulating TIMP1 should be incorporated into risk stratification to identify patients undergoing TAVR who are at a higher risk of death. 95% CI, 2.69.7];P<0.001)

Aortic valve 45

Aortic valve Aortic TAVR Biomarkers 45

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Here, we studied the vascular expression of the key angiogenic factors, VEGFα and its antagonist angiostatin, in Fabry α-GAL-Tg/KO mice and determined circulating VEGFα and angiostatin serum levels in patients with Fabry’s disease and healthy controls. vs. 858.8 ± 599.3 pg/ml).

Aortic 69

Aortic Biomarkers Circulation 69

Circulation

AUGUST 12, 2024

Circulation, Ahead of Print. Pathogeneses include connective tissue disorders, smooth muscle contraction disorders, and congenital heart disease, including bicuspid aortic valve, among others. The American Heart Association has published guidelines for diagnosis and management of thoracic aortic disease.

Pediatrics 81

Pediatrics Congenital Heart Disease Aortic valve Bicuspid/Mitral 81

Circulation: Heart Failure

JANUARY 20, 2025

Circulation: Heart Failure, Ahead of Print. The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle.

Cardiogenic Shock 40

Cardiogenic Shock Heart Failure Circulation Physiology 40

Circulation: Cardiovascular Imaging

DECEMBER 4, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 12 , Page e017425, December 1, 2024. BACKGROUND:In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. weeks post-AVR. weeks post-AVR.

Aortic valve 40

Aortic valve Aortic Stenosis Cardiovascular Imaging 40

Circulation: Cardiovascular Interventions

OCTOBER 17, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Data concerning the outcomes of transcatheter aortic valve replacement in type 0 bicuspid aortic stenosis (AS) are scarce. Ascending aortic diameter was the single predictor of 1-year mortality in type 0 bicuspid patients (hazard ratio, 1.59 [95% CI, 1.03–2.44];P=0.035).

Aortic valve 40

Aortic valve Bicuspid/Mitral Aortic Tricuspid 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4145296-A4145296, November 12, 2024. Aortic valve stenosis (AS) is often a contraindication to liver transplantation (LT). Aortic valve peak velocity (AVVmax) increased steadily as patients neared transplant and dropped significantly immediately after transplantation (Figure 1A).

Aortic valve 40

Aortic valve Aortic Transplant Stenosis 40

Circulation: Cardiovascular Interventions

NOVEMBER 20, 2023

Circulation: Cardiovascular Interventions, Volume 16, Issue 11 , Page e012966, November 1, 2023. Transcatheter aortic valve replacement (TAVR) is increasingly being performed in younger and lower surgical risk patients.

Aortic valve 40

Aortic valve Aortic TAVR Heart Valves 40

Circulation

OCTOBER 23, 2024

Circulation, Ahead of Print. The groups were stratified by aortic valve morphology (BAV, n=589; TAV, n=558). The outcomes of interests were new-onset third-degree AV block or new-onset LBBB during the index hospitalization.

Aortic valve 40

Aortic valve Bicuspid/Mitral Aortic Tricuspid 40

Open Heart

MARCH 24, 2023

Our perspectives on aortic stenosis (AS) are changing. Novel approaches are developing to address this through: (1) screening with circulating biomarkers; (2) development of drugs to slow disease progression and (3) early valve intervention guided by medical imaging. Currently, invasive intervention is the only treatment for AS.

Stenosis 52

Stenosis Aortic Aortic valve Biomarkers 52

Circulation

JANUARY 23, 2024

Circulation, Ahead of Print. BACKGROUND:Calcification of the aortic valve leads to increased leaflet stiffness and consequently results in the development of calcific aortic valve disease (CAVD). However, the underlying molecular and cellular mechanisms of calcification remain unclear.

Aortic valve 45

Aortic valve Aortic Diet Cholesterol 45

Circulation

FEBRUARY 15, 2024

Circulation, Ahead of Print. Aortic aneurysm and dissection are high-risk cardiovascular diseases without an effective cure. RNA-sequencing analysis was performed to recapitulate possible changes in the transcriptome profile of SNO-Septin2 in macrophages in aortic aneurysm and dissection.

Aneurysm 45

Aneurysm Aortic Cardiovascular Disease Pharmacology 45

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4148073-A4148073, November 12, 2024. Case Description:A 26 yo woman with Marfan Syndrome (MFS,FBN1), ectopia lentis, aortic dilation and no family history of MFS or aortic dissection was evaluated for preconception counseling. Our patient’s pathogenicFBN1mutation (-c.2114-5T>G,

Aortic 40

Aortic Aortic valve Education Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144671-A4144671, November 12, 2024. Among them, 1404 (91%) patients underwent aortic cross-clamp during systemic cooling. The completeness of the cross-cramp was 99.9%.

Aortic 40

Aortic Circulation Risk Factors Stroke 40

Frontiers in Cardiovascular Medicine

APRIL 18, 2024

Binary logistic regression identified five critical determinants regarding poor renal recovery, including chronic kidney disease (CKD) history, renal hypoperfusion, circulation arrest time, intraoperative urine, and myoglobin. Among the PO-AKI cohort, the LCMM identified two distinct eGFR trajectories: early recovery (ER-AKI, 51.8%

Aortic 52

Aortic ICU Kidney Disease Circulation 52

Frontiers in Cardiovascular Medicine

AUGUST 4, 2024

BackgroundThe aorta, a central component of the cardiovascular system, plays a pivotal role in ensuring blood circulation.

Aortic 52

Aortic Circulation 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4138340-A4138340, November 12, 2024. Background:Calcific Aortic Valve Disease is a common cardiac condition with no effective medication available; severe cases require surgery. Immunohistochemical staining showed high expression of Cav-1 in calcified aortic valves.

Aortic valve 40

Aortic valve Aortic Circulation 40

Circulation

OCTOBER 25, 2023

Circulation, Ahead of Print. Background:The optimal treatment in patients with severe aortic stenosis (AS) and small aortic annulus (SAA) remains to be determined. Clinical events were secondary outcomes.Results:The mean age of the participants was 75±5 years, with 140 (93%) women, a median STS of 2.50 (1.67-3.28)%,

Aortic valve 40

Aortic valve Aortic TAVR Stenosis 40

Circulation: Heart Failure

NOVEMBER 11, 2024

Circulation: Heart Failure, Ahead of Print. Background:Distinguishing hypertrophic cardiomyopathy (HCM) from other cardiomyopathies with left ventricular hypertrophy (LVH), such as hypertensive LVH, transthyretin amyloid cardiomyopathy (ATTR-CM), and aortic stenosis (AS), is sometimes challenging.

Cardiomyopathy 40

Cardiomyopathy Biomarkers Circulation Hypertension 40

Circulation

FEBRUARY 25, 2024

Circulation, Volume 149, Issue 9 , Page 656-657, February 27, 2024.

Aortic 49

Aortic Stenosis Circulation 49

Circulation

FEBRUARY 13, 2024

Circulation, Ahead of Print. 4-HNE promoted calcification of both mouse aortic smooth muscle cells and human aortic smooth muscle cells and their osteochondrogenic differentiation in vitro. Vascular calcification is associated with increased cardiovascular adverse events.

Coronary Artery Disease 80

Coronary Artery Disease Kidney Disease Aortic Plaque 80

DAIC

FEBRUARY 3, 2025

Lp(a) is emerging as an important, yet under-recognized, potential risk factor for cardiovascular disease due to its ability to promote the development of plaques within artery walls, clot formation and aortic valve calcification. Circulation. 2022 Aug, 80 (9) 934946 Kronenberg F. Arnett DK et al. 2019 Sep 10;140(11):e563-e595.

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142104-A4142104, November 12, 2024.

Aortic valve 40

Aortic valve Aortic TAVR Stroke 40

Circulation

OCTOBER 6, 2024

Circulation, Volume 150, Issue 15 , Page 1155-1157, October 8, 2024.

Aortic 49

Aortic Circulation 49

Circulation

JUNE 17, 2024

Circulation, Ahead of Print. We focus on the most common primary valvular heart diseases, including calcific aortic stenosis, bicuspid aortic valves, mitral valve prolapse, and rheumatic heart disease, and outline the fundamental molecular discoveries contributing to each.

Bicuspid/Mitral 65

Bicuspid/Mitral Heart Disease Aortic valve Heart Valves 65

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4140451-A4140451, November 12, 2024. Partial- or total loss of Sca-1 expression exacerbated aortic GFP+CD31-CD45-cell expansion, compared to Sca1GFP [Sca1KI-/-32±7-fold change of vehiclevs.Sca1KI+/-39±9vs.Sca1GFP 5±1; n=11-13/group; p<0.0001], suggesting disinhibited progenitor responses.

Aortic 40

Aortic Hypertension Aneurysm Circulation 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4119619-A4119619, November 12, 2024. Background:Peak aortic valve Doppler velocity, mean aortic valve gradient, and Doppler estimated aortic valve area are key measures recommended for assessing aortic stenosis severity.

Stenosis 40

Stenosis Aortic valve Aortic Echocardiogram 40

Circulation

JUNE 30, 2024

Circulation, Volume 150, Issue 1 , Page 47-48, July 2, 2024.

Aneurysm 49

Aneurysm Aortic Circulation 49

Circulation

MARCH 2, 2025

Circulation, Volume 151, Issue 9 , Page e682-e683, March 4, 2025.

Article 49

Article Aneurysm Aortic Circulation 49

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142845-A4142845, November 12, 2024. Introduction:Uncomplicated Stanford type B acute aortic dissection is traditionally managed with strict blood pressure control. Statistical analyses were performed using Welch's t-test, and statistical significance was defined as p < 0.05.

Aortic 40

Aortic Blood Pressure Aneurysm Outcomes 40

Heart BMJ

MARCH 22, 2024

Objectives This study aimed to evaluate the prognostic value of coronary microvascular dysfunction (CMD) at long term after transcatheter aortic valve implantation (TAVI) and to explore its relationship with extravalvular cardiac damage (EVCD). CMD was defined as IMR angio ≥30 units.

Aortic valve 40

Aortic valve Aortic Tricuspid Heart Failure 40

Circulation: Cardiovascular Imaging

JANUARY 8, 2025

Circulation: Cardiovascular Imaging, Ahead of Print.

Aortic valve 40

Aortic valve Aortic Cardiovascular Imaging Stenosis 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142998-A4142998, November 12, 2024. Introduction:Subclinical leaflet thrombosis is an increasingly recognized complication in patients undergoing transcatheter aortic valve replacement (TAVR).

Aortic valve 40

Aortic valve Thrombosis Aortic TAVR 40

DAIC

MAY 8, 2024

Recommendations Plan for alternative capital equipment to transition away from these Getinge cardiovascular devices: Getinge/Maquet/Datascope Cardiosave Hybrid and Rescue Intra-Aortic Balloon Pump (IABP) devices. The device is an electromechanical system used to inflate and deflate intra-aortic balloons. for the Cardiosave IABP.

Certification 98

Certification Aortic Education Circulation 98

Circulation

NOVEMBER 29, 2023

Circulation, Ahead of Print. BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to prevent AAA progression and rupture are currently lacking. RNA sequencing analysis showed thatST3GAL5silencing in human aortic SMCs induced ferroptosis.

Aneurysm 40

Aneurysm Aortic Atherosclerosis Risk Factors 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4139822-A4139822, November 12, 2024. Digging into and unravelling the pathogenesis of AD will aid in exploring novel therapeutics for AD.The major characteristics of AD is degeneration of aortic wall architecture.

Aortic 40

Aortic Physiology Circulation 40

Circulation

NOVEMBER 29, 2023

Circulation, Ahead of Print. BACKGROUND:A better understanding of the molecular mechanism of aortic valve development and bicuspid aortic valve (BAV) formation would significantly improve and optimize the therapeutic strategy for BAV treatment.

Aortic valve 40

Aortic valve Bicuspid/Mitral Aortic Circulation 40