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Systemic Circulation in Advanced Heart Failure and Cardiogenic Shock: State-of-the-Art Review

Circulation: Heart Failure

The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle.

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Abstract 4143363: Direct Left Ventricular Unloading Vs Counter Pulsation Support Exhibits Differential miRNA Expression In The Left Ventricle Of Cardiogenic Shock Patients

Circulation

Background:Various temporary mechanical circulatory support device (t-MCS) options are available for supporting patients in cardiogenic shock. While each device has a different physiological impact on the heart, limited studies compare genetic changes in the heart t-MCS. and 4 bridged with IABP.

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Magenta Medical, Developer of World’s Smallest Heart Pump, Closes $105M Financing Round

DAIC

FDA for two clinical indications: high-risk percutaneous coronary intervention (HR-PCI) and cardiogenic shock (CS). The pump is delivered into the heart fully sheathed, over a guidewire, through the aorta, and across the aortic valve. Magenta completed a U.S. Early Feasibility Study with the HR-PCI indication in 2023.

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Diffuse Subendocardial Ischemia on the ECG. Left main? 3-vessel disease? No!

Dr. Smith's ECG Blog

Look at the aortic outflow tract. The diagnostic coronary angiogram identified only minimal coronary artery disease, but there was a severely calcified, ‘immobile’ aortic valve. Aortic angiogram did not reveal aortic dissection. In fact, bedside ultrasound might even find severe aortic stenosis. What do you see?

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Advanced hemodynamics for prognostication in heart failure: the pursuit of the patient-specific tipping point

Frontiers in Cardiovascular Medicine

Methods Here, a mathematical and physiological framework to define the patient-specific tipping point of myocardial energetics is defined. A novel hemodynamic parameter known as the myocardial performance score (MPS), a marker of power and efficiency, is introduced that allows for the objective assessment of the physiological tipping point.