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The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenicshock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle.
Background:Various temporary mechanical circulatory support device (t-MCS) options are available for supporting patients in cardiogenicshock. While each device has a different physiological impact on the heart, limited studies compare genetic changes in the heart t-MCS. and 4 bridged with IABP.
FDA for two clinical indications: high-risk percutaneous coronary intervention (HR-PCI) and cardiogenicshock (CS). The pump is delivered into the heart fully sheathed, over a guidewire, through the aorta, and across the aortic valve. Magenta completed a U.S. Early Feasibility Study with the HR-PCI indication in 2023.
Look at the aortic outflow tract. The diagnostic coronary angiogram identified only minimal coronary artery disease, but there was a severely calcified, ‘immobile’ aortic valve. Aortic angiogram did not reveal aortic dissection. In fact, bedside ultrasound might even find severe aortic stenosis. What do you see?
Methods Here, a mathematical and physiological framework to define the patient-specific tipping point of myocardial energetics is defined. A novel hemodynamic parameter known as the myocardial performance score (MPS), a marker of power and efficiency, is introduced that allows for the objective assessment of the physiological tipping point.
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