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Abstract 4134695: The Effect and Mechanism of Histone Lactylation In Pathological Cardiac Hypertrophy Induced by Pressure Overload

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4134695-A4134695, November 12, 2024. To investigate further, male mice underwent transverse aortic constriction (TAC) to induce cardiac hypertrophy, followed by either an intraperitoneal injection of Oxamate (an LDHA inhibitor) to reduce histone lactylation or sodium lactate to increase it.

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Abstract 4115947: Empagliflozin Inhibits the Mobilization of CCR2+ Monocyte-Derived Macrophages by Reducing CCL2 Expression in Fibroblasts and Slows the Progression of Heart Failure After Pressure Overload.

Circulation

Circulation, Volume 150, Issue Suppl_1 , Page A4115947-A4115947, November 12, 2024. Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiac function was reassessed.

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Aerobic Exercise Attenuates Pressure Overload–Induced Myocardial Remodeling and Myocardial Inflammation via Upregulating miR-574-3p in Mice

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates.