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Circulation, Volume 150, Issue Suppl_1 , Page A4134695-A4134695, November 12, 2024. To investigate further, male mice underwent transverse aortic constriction (TAC) to induce cardiac hypertrophy, followed by either an intraperitoneal injection of Oxamate (an LDHA inhibitor) to reduce histone lactylation or sodium lactate to increase it.
Circulation, Volume 150, Issue Suppl_1 , Page A4115947-A4115947, November 12, 2024. Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiacfunction was reassessed.
Circulation: Heart Failure, Ahead of Print. BACKGROUND:Exercise training can promote cardiac rehabilitation, thereby reducing cardiovascular disease mortality and hospitalization rates.
Patients with aortic/mitral/tricuspid valve disease or root/ascending aorta >40 mm were included as soon as they were diagnosed with heart valve disease. tim.hodson Tue, 02/18/2025 - 16:41 Feb.
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