DAIC

JUNE 7, 2024

Getty Images milla1cf Fri, 06/07/2024 - 15:10 June 7, 2024 — Calcific aortic valve disease (CAVD) is the major heart valve disease that afflicts nearly 10 million patients globally with an annual mortality exceeding 100,000, and the numbers continue to rise. These findings appear online in the journal Trends in Molecular Medicine.

Aortic valve 105

Aortic valve Aortic Heart Valves Pharmacology 105

Frontiers in Cardiovascular Medicine

MARCH 26, 2024

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases.

Cardiac Function 64

Cardiac Function Aortic Strokes Stroke 64

European Journal of Heart Failure

JANUARY 21, 2024

Bar plots: in red, patients with low flow-low gradient (LF-LG) aortic stenosis; in blue, patients with normal flow-high gradient (HG) aortic stenosis; in black: controls. Main findings of the study. p  < 0.05 for HG and LF-LG vs. control; § p  < 0.05

Stenosis 40

Stenosis Aortic Aortic valve Coronary Artery Disease 40

Circulation

NOVEMBER 11, 2024

To investigate further, male mice underwent transverse aortic constriction (TAC) to induce cardiac hypertrophy, followed by either an intraperitoneal injection of Oxamate (an LDHA inhibitor) to reduce histone lactylation or sodium lactate to increase it.

Cardiac Function 40

Cardiac Function Aortic Circulation 40

Circulation

NOVEMBER 11, 2024

Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiac function was reassessed.

Heart Failure 40

Heart Failure Cardiac Function Myocardial Infarction Aortic 40

Frontiers in Cardiovascular Medicine

OCTOBER 7, 2024

A set of 82 CMR traits was obtained from a recent GWAS, serving as preclinical indicators and providing preliminary insights into the morphology and function of the four cardiac chambers and two aortic segments. Primary analysis employed a two-sample Mendelian randomization study using the inverse-variance weighted method.

Cardiac Function 59

Cardiac Function Aortic Heart Disease Research 59

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Cardiomyocyte-specific Tfeb knockout (cKO) and wildtype (WT) male mice were subjected to 27G transverse aortic constriction or sham surgery for 21 and 56 days, respectively, to induce LVH and HFrEF. Methods Luciferase assays were performed to verify that TFEB regulates PPARGC1A expression.

Heart Failure 59

Heart Failure Cardiac Function Aortic 59