Aortic and Cardiac Function - Cardiovascular Update

New Study Suggests that Amyloid Contributes to Calcific Aortic Valve Disease Development

DAIC

JUNE 7, 2024

Getty Images milla1cf Fri, 06/07/2024 - 15:10 June 7, 2024 — Calcific aortic valve disease (CAVD) is the major heart valve disease that afflicts nearly 10 million patients globally with an annual mortality exceeding 100,000, and the numbers continue to rise. These findings appear online in the journal Trends in Molecular Medicine.

Aortic valve

Aortic valve Aortic Heart Valves Pharmacology

Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Frontiers in Cardiovascular Medicine

MARCH 26, 2024

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases.

Cardiac Function

Cardiac Function Aortic Stroke Strokes

Management of acute decompensated valvular heart disease

European Journal of Heart Failure

DECEMBER 11, 2024

In acute heart failure caused by VHD, symptoms result from rapid haemodynamic changes and subsequent decline in cardiac function, and if left untreated, leads to acute decompensation and cardiogenic shock. Abstract Worldwide, valvular heart disease (VHD) is a common cause of hospitalization for acute heart failure.

Cardiogenic Shock

Cardiogenic Shock Heart Disease Heart Failure Bicuspid/Mitral

Cardiologists Train Large AI Model to Assess Heart Structure, Function

DAIC

MAY 2, 2024

The team of investigators built a dataset of 1,032,975 cardiac ultrasound videos and corresponding expert interpretations to develop EchoCLIP. Key takeaways from the study include: EchoCLIP displayed strong performance when assessing cardiac function using heart images.

Echocardiogram

Echocardiogram Ultrasound Aortic valve Bicuspid/Mitral

Myocardial sodium–glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO?AS study

European Journal of Heart Failure

JANUARY 21, 2024

Bar plots: in red, patients with low flow-low gradient (LF-LG) aortic stenosis; in blue, patients with normal flow-high gradient (HG) aortic stenosis; in black: controls. Main findings of the study. p < 0.05 for HG and LF-LG vs. control; § p < 0.05

Stenosis

Stenosis Aortic Aortic valve Coronary Artery Disease

Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Cardiomyocyte-specific Tfeb knockout (cKO) and wildtype (WT) male mice were subjected to 27G transverse aortic constriction or sham surgery for 21 and 56 days, respectively, to induce LVH and HFrEF. Methods Luciferase assays were performed to verify that TFEB regulates PPARGC1A expression.

Heart Failure

Heart Failure Cardiac Function Aortic

Impact of systemic lupus erythematosus on cardiovascular morphologic and functional phenotypes: a Mendelian randomization analysis

Frontiers in Cardiovascular Medicine

OCTOBER 7, 2024

A set of 82 CMR traits was obtained from a recent GWAS, serving as preclinical indicators and providing preliminary insights into the morphology and function of the four cardiac chambers and two aortic segments. Primary analysis employed a two-sample Mendelian randomization study using the inverse-variance weighted method.

Cardiac Function

Cardiac Function Aortic Heart Disease Research

Abstract 4134695: The Effect and Mechanism of Histone Lactylation In Pathological Cardiac Hypertrophy Induced by Pressure Overload

Circulation

NOVEMBER 11, 2024

To investigate further, male mice underwent transverse aortic constriction (TAC) to induce cardiac hypertrophy, followed by either an intraperitoneal injection of Oxamate (an LDHA inhibitor) to reduce histone lactylation or sodium lactate to increase it.

Cardiac Function

Cardiac Function Aortic Circulation

Ovarian Tumor Domain?Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel?Like Factor 4

Journal of the American Heart Association

DECEMBER 12, 2023

Therefore, we investigated the role of OTUD7B in CH.Methods and ResultsOTUD7B knockout mice were used to assay the role of OTUD7B in CH after transverse aortic coarctation surgery. We further assayed the specific functions of OTUD7B in isolated neonatal rat cardiomyocytes.

Pharmacology

Pharmacology Aortic Cardiac Function Risk Factors

Abstract 4115947: Empagliflozin Inhibits the Mobilization of CCR2+ Monocyte-Derived Macrophages by Reducing CCL2 Expression in Fibroblasts and Slows the Progression of Heart Failure After Pressure Overload.

Circulation

NOVEMBER 11, 2024

Two weeks post-TAC, with heart function confirmed as equal across all groups by echocardiography, one group began receiving daily oral doses of empagliflozin, while another served as the control. At four weeks post-TAC, cardiac function was reassessed.

Heart Failure

Heart Failure Cardiac Function Myocardial Infarction Aortic

Aerobic Exercise Attenuates Pressure Overload–Induced Myocardial Remodeling and Myocardial Inflammation via Upregulating miR-574-3p in Mice

Circulation: Heart Failure

FEBRUARY 27, 2024

After swimming training, echocardiography was used to evaluate cardiac function in mice, and histopathologic staining was used to detect cardiac hypertrophy, myocardial fibrosis, and cardiac inflammation.

Exercise

Exercise Cardiac Rehabilitation Cardiac Function Heart Failure

Taskforce Develops New Standards to Monitor Adults with Heart Valve Disease

DAIC

FEBRUARY 18, 2025

Patients with aortic/mitral/tricuspid valve disease or root/ascending aorta >40 mm were included as soon as they were diagnosed with heart valve disease.

Heart Valves

Heart Valves Quality of Life Cardiothoracic Outcomes

Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2025

BackgroundLong-term mortality risk is seldom re-assessed in contemporary clinical practice following successful transcatheter aortic valve implantation (TAVR). k-means clustering was performed on data from 200 patients who underwent TAVR for severe aortic stenosis (AS).

Aortic valve

Aortic valve Aortic TAVR Cardiac Function

New Study Suggests that Amyloid Contributes to Calcific Aortic Valve Disease Development

Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Management of acute decompensated valvular heart disease

Cardiologists Train Large AI Model to Assess Heart Structure, Function

Myocardial sodium–glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO?AS study

Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice

Impact of systemic lupus erythematosus on cardiovascular morphologic and functional phenotypes: a Mendelian randomization analysis

Abstract 4134695: The Effect and Mechanism of Histone Lactylation In Pathological Cardiac Hypertrophy Induced by Pressure Overload

Ovarian Tumor Domain?Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel?Like Factor 4

Abstract 4115947: Empagliflozin Inhibits the Mobilization of CCR2+ Monocyte-Derived Macrophages by Reducing CCL2 Expression in Fibroblasts and Slows the Progression of Heart Failure After Pressure Overload.

Aerobic Exercise Attenuates Pressure Overload–Induced Myocardial Remodeling and Myocardial Inflammation via Upregulating miR-574-3p in Mice

Taskforce Develops New Standards to Monitor Adults with Heart Valve Disease

Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients

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