article thumbnail

A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression

JAMA Cardiology

This cohort study explores whether a novel artificial intelligence (AI) video-based biomarker for aortic stenosis is associated with development and progression of aortic stenosis.

Stenosis 102
article thumbnail

Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States

Frontiers in Cardiovascular Medicine

BackgroundAbdominal aortic calcification (AAC), an early indicator of abdominal aortic wall atherosclerosis, is a marker of subclinical atherosclerosis and a predictive factor for vascular-associated morbidity and mortality. These outcomes are driven by inflammatory processes.

Aortic 52
article thumbnail

Overexpression of VEGF? as a biomarker of endothelial dysfunction in aortic tissue of ?-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry’s disease

Frontiers in Cardiovascular Medicine

Methods Cryopreserved aortic vessels from six α-GAL-Tg/KO and six wild-type (WT) mice were obtained and VEGFα and angiostatin levels were determined by performing Western blot analysis. VEGFα expression was visualized by an immunohistochemical staining of paraffin aortic rings. vs. 858.8 ± 599.3 pg/ml).

Aortic 69
article thumbnail

Single-cell RNA sequencing and ATAC sequencing identify novel biomarkers for bicuspid aortic valve-associated thoracic aortic aneurysm

Frontiers in Cardiovascular Medicine

IntroductionBicuspid aortic valve (BAV) is the most prevalent congenital cardiovascular defect and known to cause thoracic aortic aneurysms (TAAs).

article thumbnail

Biomarkers to predict the outcomes of surgical intervention for aortic dissection

Journal of Cardiothoracic Surgery

Aortic dissections and repairs are associated with high rates of mortality. The aim of this review is to summarize the literature concerning the prognostic ability of various preoperative biomarkers for patien.

article thumbnail

Early Valve Replacement Guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients With Severe Aortic Stenosis

American College of Cardiology

The goal of the EVOLVED trial was to assess the safety and efficacy of early aortic valve replacement compared with conservative management among patients with asymptomatic severe aortic stenosis, normal ejection fraction (EF), and presence of myocardial fibrosis on cardiac magnetic resonance imaging (CMR).

article thumbnail

Roche's Lp(a) Gen.2 Molarity Assay Receives FDA Clearance

DAIC

This clearance comes in advance of disease-modifying therapies on the horizon expected to help clinicians use this biomarker to guide patients to improved cardiovascular health, saidBrad Moore, president and CEO at Roche Diagnostics North America. The development of the Tina-quant Lipoprotein (a) Gen.2 2022 Aug, 80 (9) 934946 Kronenberg F.