Journal of the American Heart Association

JANUARY 19, 2024

BackgroundAortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. The resulting cholesterol crystals activate the NLRP3 (NOD‐like receptor protein 3) inflammasome, leading to inflammation and cardiovascular diseases.

Aortic valve 40

Aortic valve Cholesterol Aortic Stenosis 40

Journal of the American Heart Association

FEBRUARY 23, 2024

BackgroundChronic inflammatory disease (CID) accelerates atherosclerosis and the development of aortic stenosis. Data on long‐term outcomes after transcatheter aortic valve implantation (TAVI) in those patients are missing.

Aortic valve 49

Aortic valve Aortic Outcomes Atrial Fibrillation 49

Journal of the American Heart Association

JANUARY 12, 2024

years [SD, 4.1]) from the ARIC (Atherosclerosis Risk in Communities) study, we measured segment‐specific PWVs: heart–carotid, heart–femoral, carotid–femoral, heart–ankle, brachial–ankle, and femoral–ankle.

Atherosclerosis 45

Atherosclerosis Aortic valve Aortic Bicuspid/Mitral 45

Frontiers in Cardiovascular Medicine

MARCH 3, 2024

Introduction The presence of abdominal aortic calcification (AAC) is strongly linked to the development of atherosclerosis and the incidence of morbidity and mortality related to cardiovascular diseases (CVD). Urinary albumin creatinine ratio (UACR) was found related with the increased risk of CVD.

Aortic 59

Aortic Atherosclerosis Cardiovascular Disease 59

Open Heart

MARCH 24, 2023

Our perspectives on aortic stenosis (AS) are changing. The pathophysiology of calcific AS (CAS) is complex, yet can be characterised similarly to that of atherosclerosis. In addition, their integration with cardiovascular MRI can provide accurate risk stratification, aiding aortic valve replacement decision making.

Stenosis 52

Stenosis Aortic Aortic valve Biomarkers 52

Circulation

NOVEMBER 29, 2023

BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to prevent AAA progression and rupture are currently lacking. GM3 content and ST3GAL5 expression were decreased in abdominal aortic vascular SMCs in patients with AAA and an AAA mouse model.

Aneurysm 40

Aneurysm Aortic Atherosclerosis Risk Factors 40

Open Heart

MAY 31, 2022

This study examined whether HGF is associated with ECC in the aortic valve (AVC), mitral annulus (MAC), ascending thoracic aorta and descending thoracic aortic (DTAC). However, knowledge is limited on the role HGF may play in extracoronary calcification (ECC).

Atherosclerosis 52

Atherosclerosis Aortic valve Risk Factors Aortic 52

Frontiers in Cardiovascular Medicine

FEBRUARY 26, 2024

Objective Cell division cycle 42 (CDC42) regulates CD4 + T -cell differentiation and participates in vascular stiffness and atherosclerosis and is involved in the progression of Stanford type B aortic dissection (TBAD).

Hospital 59

Hospital Aortic Atherosclerosis 59

The British Journal of Cardiology

AUGUST 1, 2024

Genome-wide association and Mendelian randomisation studies have identified lipoprotein(a) (Lp[a]) as an emerging risk factor for calcific aortic stenosis and a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) in different ethnicities. HEART UK recommends Lp(a) measurement in specific ‘at-risk’ cohorts.

Risk Factors 52

Risk Factors Atherosclerosis Laboratory Stenosis 52

Circulation

NOVEMBER 8, 2023

BACKGROUND:High circulating levels of Lp(a) (lipoprotein[a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of patients worldwide.

Aortic valve 40

Aortic valve Heart Disease Atherosclerosis Aortic 40

Heart BMJ

JUNE 25, 2024

This study compared the prognostic value of quantified thoracic artery calcium (TAC) including aortic arch on chest CT and coronary artery calcium (CAC) score on ECG-gated cardiac CT. TAC is defined as calcification in the ascending aorta, aortic arch and descending aorta on chest CT.

Cardiovascular Disease 59

Cardiovascular Disease Aortic Atherosclerosis 59

Frontiers in Cardiovascular Medicine

JUNE 30, 2024

We then summarize current knowledge of the roles played by ERK in the development and progression of cardiac and vascular disorders, including atherosclerosis, myocardial infarction, cardiac hypertrophy, heart failure, and aortic aneurysm.

Cardiovascular Disease 52

Cardiovascular Disease Quality of Life Myocardial Infarction Aneurysm 52

Dr. Paddy Barrett

NOVEMBER 7, 2023

The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. It is the inflammatory response to this particle retention that causes the formation of atherosclerosis 1. Lipoprotein particles entering the subintimal space causing atherosclerosis. CE = Cholesterol Ester.

Cholesterol 52

Cholesterol Atherosclerosis Stenosis Aortic 52

Hypertension Journal

JANUARY 2, 2024

The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm. BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms.

Aneurysm 45

Aneurysm Pharmacology Atherosclerosis Hemorrhage 45

Dr. Smith's ECG Blog

MAY 20, 2024

The Queen of Hearts disagrees, diagnosing OMI with high confidence: Case Continued: The EKG was not immediately recognized by the emergency provider, who ordered a CT scan to rule out aortic dissection at 1419. There is an area of dense white in the middle of the circle consistent with atherosclerosis. The blue circle shows the LCx.

Chest Pain 124

Chest Pain Blood Pressure Ischemia STEMI 124

The British Journal of Cardiology

AUGUST 1, 2024

Lipoprotein(a) (Lp[a]) can improve the accuracy of assessment of atherosclerotic cardiovascular disease and the risk of aortic valve stenosis. Currently, there is no specific treatment to lower its circulating concentration. Raised Lp(a) is a feature of familial hypercholesterolaemia.

Aortic valve 52

Aortic valve Heart Disease Blood Pressure Risk Factors 52

DAIC

JANUARY 23, 2024

1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3 1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. 4 In the U.S.

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

A 69‐year‐old woman with a history of lung cancer, hypertension, chronic tobacco use, atherosclerosis, and known calcified plaque at the left carotid bifurcation on dual antiplatelet therapy presented with acute onset of expressive aphasia and right hemiparesis due to acute left CCAO.

Outcomes 40

Outcomes Coronary Artery Disease Chest Pain Aortic 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Repeat CTA head and neck demonstrated multifocal intracranial atherosclerosis with marked stenosis of the left V4 segment. However, marked stenosis at V2 appeared to be owed to external compression from facet arthrosis rather than atherosclerosis. He also had moderate stenosis of the right V4 segment.

Stenosis 40

Stenosis Peripheral Arterial Disease Atherosclerosis Pacemaker 40

Hypertension Journal

FEBRUARY 6, 2024

Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease. Hypertension, Ahead of Print.

Aortic 40

Aortic Atherosclerosis Pharmacology Aneurysm 40

Dr. Smith's ECG Blog

JANUARY 3, 2022

Cardiology noted there was no STEMI criteria and the first troponin was in the normal range (25ng/L, with normal <26), so alternate diagnoses were considered and the patient was sent for CT to rule out aortic dissection. 4] CT revealed no dissection but extensive coronary atherosclerosis. In a study last year, 14.4%

STEMI 52

STEMI Myocardial Infarction Chest Pain Ischemia 52

Circulation

DECEMBER 15, 2023

Mechanistically, HEG1 knockdown prevented s-flow–induced KLF2/4 (Krüppel-like factor 2/4) expression by regulating its intracellular binding partner KRIT1 (Krev interaction trapped protein 1) and the MEKK3-MEK5-ERK5-MEF2 pathway in human aortic endothelial cells. Circulation, Ahead of Print.

Atherosclerosis 45

Atherosclerosis Diet Aortic Plaque 45

Physiologically Speaking

APRIL 24, 2024

The amount of calcium in the blood vessels (known as arterial calcification), a marker of subclinical atherosclerosis, is higher in people with a short sleep duration. 13 Coronary artery calcification (CAC) and aortic stiffness are also associated with self-reported sleep duration.

Blood Pressure 52

Blood Pressure Blood Clot COVID-19 Cardiovascular Disease 52