Remove Aortic Remove Aortic valve Remove Atherosclerosis
article thumbnail

New Study Suggests that Amyloid Contributes to Calcific Aortic Valve Disease Development

DAIC

Getty Images milla1cf Fri, 06/07/2024 - 15:10 June 7, 2024 — Calcific aortic valve disease (CAVD) is the major heart valve disease that afflicts nearly 10 million patients globally with an annual mortality exceeding 100,000, and the numbers continue to rise.

article thumbnail

Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis

Heart BMJ

Objective Aortic stenosis (AS) shares pathophysiological similarities with atherosclerosis including active inflammation. CT attenuation of perivascular adipose tissue provides a measure of vascular inflammation that is linked to prognosis and has the potential to be applied to the aortic valve. HU, p=0.099).

article thumbnail

Brachiocephalic Artery Access for Transcatheter Aortic Valve Replacement

All About Cardiovascular System and Disorders

Transcatheter aortic valve replacement (TAVR) is increasing in popularity for symptomatic severe aortic stenosis. Transfemoral arterial route is the most commonly used approach for TAVR, also known as TAVI or transcatheter aortic valve implantation.

article thumbnail

Long?Term Outcomes After Transcatheter Aortic Valve Implantation in Patients With Chronic Inflammatory Disease

Journal of the American Heart Association

BackgroundChronic inflammatory disease (CID) accelerates atherosclerosis and the development of aortic stenosis. Data on long‐term outcomes after transcatheter aortic valve implantation (TAVI) in those patients are missing.

article thumbnail

Cholesterol Crystal Dissolution Rate of Serum Predicts Outcomes in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement

Journal of the American Heart Association

BackgroundAortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. The resulting cholesterol crystals activate the NLRP3 (NOD‐like receptor protein 3) inflammasome, leading to inflammation and cardiovascular diseases.

article thumbnail

Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome

Frontiers in Cardiovascular Medicine

Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare genetic premature aging disease that is historically fatal in teenage years, secondary to severe accelerated atherosclerosis. With this longer lifespan, calcific aortic stenosis (AS) was identified as an emerging critical risk factor for cardiac death in older patients.

article thumbnail

Association of Segment?Specific Pulse Wave Velocity With Vascular Calcification: The ARIC (Atherosclerosis Risk in Communities) Study

Journal of the American Heart Association

years [SD, 4.1]) from the ARIC (Atherosclerosis Risk in Communities) study, we measured segment‐specific PWVs: heart–carotid, heart–femoral, carotid–femoral, heart–ankle, brachial–ankle, and femoral–ankle.