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Heart Failure With Preserved Ejection Fraction Phenotype Is Associated With Early Symptom Onset in Aortic Stenosis and Residual Symptoms After Transcatheter Aortic Valve Implantation

Journal of the American Heart Association

BackgroundAortic stenosis can lead to cardiac adaptations and symptoms similar to heart failure with preserved ejection fraction. Methods and ResultsThis retrospective cohort study included 469 patients with moderate aortic stenosis. versus 4.4 m/s in patients with a low H2FPEF score (P<0.001).

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American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m. ET Murphy Ballroom 4 ACC.24 24 planners note that attendees can gain insights from key clinical trials presented at ACC.24

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Systematic review and meta-analysis of early aortic valve replacement versus conservative therapy in patients with asymptomatic aortic valve stenosis with preserved left ventricle systolic function

Open Heart

Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines.

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Haemodynamic and metabolic phenotyping of patients with aortic stenosis and preserved ejection fraction: A specific phenotype of heart failure with preserved ejection fraction?

European Journal of Heart Failure

Venn diagram highlighting the main similarities and differences between heart failure with preserved ejection fraction (HFpEF) and aortic stenosis with preserved ejection fraction (ASpEF). HFpEF and ASpEF patients showed similar demographic distribution and biohumoral profiles.

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Exploring the mechanisms responsible for reduced systolic function in high-gradient aortic stenosis

Heart BMJ

Objective To characterise the mechanics responsible for the reduced ejection fraction (rEF) in high-gradient severe aortic stenosis (AS). Methods 21 patients with high-gradient severe AS (aortic valve area (AVA) <1.0 mm Hg/mL; p=0.05), driven by higher degrees of valvular stenosis (valve area 0.46

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Highlights of ACC 2024

Cardiology Update

SMART 4 ( NCT04722250 ) studied patients with severe aortic stenosis and a small aortic annulus who underwent transcatheter aortic valve replacement (TAVR). A total of 716 patients underwent TAVR with either a self-expanding supraannular valve or a balloon-expandable valve. vs. 6.2%) and stroke (2.9%

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