Aortic valve, Embolism and Strokes - Cardiovascular Update

Brain-Protected TAVR Results in Fewer Real-World Disabling Strokes

Med Page Today

JUNE 5, 2024

(MedPage Today) -- NEW YORK CITY -- Researchers eked out evidence of a small clinical benefit with the Sentinel cerebral embolic protection (CEP) device in transcatheter aortic valve replacement (TAVR) -- and pointed to the patients more likely.

TAVR

TAVR Aortic valve Embolism Aortic

No effect of cerebral embolic protection devices on stroke risk after TAVI

Nature Reviews - Cardiology

APRIL 9, 2025

Nature Reviews Cardiology, Published online: 10 April 2025; doi:10.1038/s41569-025-01156-9 Findings from the BHF PROTECT-TAVI trial indicate that the routine use of cerebral embolic protection devices during transcatheter aortic valve implantation does not decrease the incidence of stroke within 72 h after the intervention.

Embolism

Embolism Aortic valve Stroke Strokes

Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis

Heart BMJ

MAY 10, 2024

Objectives The use of cerebral embolic protection (CEP) during transcatheter aortic valve implantation (TAVI) has been studied in several randomised trials. We aimed to perform a systematic review and Bayesian meta-analysis of randomised CEP trials, focusing on a clinically relevant reduction in disabling stroke.

Aortic valve

Aortic valve Embolism Aortic Stroke

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Cerebral Embolic Protection for TAVI Doesn't Cut Strokes, Trial Affirms

Med Page Today

MARCH 30, 2025

(MedPage Today) -- CHICAGO -- Routine use of devices to prevent cerebral emboli during transcatheter aortic valve implantation (TAVI) did not prevent strokes, a large randomized trial showed. Incidence of stroke within 72 hours after TAVI or.

Aortic valve

Aortic valve Embolism Stroke Strokes

Cerebral Embolic Protection Devices in Transcatheter Aortic Valve Implantation: Meta‐Analysis With Trial Sequential Analysis

Journal of the American Heart Association

MARCH 21, 2025

BackgroundWe aimed to reevaluate randomized controlled trial data on outcomes of cerebral embolic protection device use during transcatheter aortic valve implantation. Primary outcomes included all stroke, disabling stroke, and allcause mortality.

Aortic valve

Aortic valve Embolism Aortic Stroke

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation

The New England Journal of Medicine

MARCH 29, 2025

In a randomized trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner).

Embolism

Embolism Aortic valve Aortic Hospital

Role of Cerebral Embolic Protection Devices in Patients Undergoing Transcatheter Aortic Valve Replacement: An Updated Meta?Analysis

Journal of the American Heart Association

JANUARY 19, 2024

BackgroundCerebral embolic protection devices (CEPD) capture embolic material in an attempt to reduce ischemic brain injury during transcatheter aortic valve replacement. Primary clinical outcome was all‐cause stroke. Secondary clinical outcomes were disabling stroke and all‐cause mortality.

Aortic valve

Aortic valve Embolism Aortic Stroke

Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

American College of Cardiology

OCTOBER 29, 2024

The goal of the PROTECTED TAVR trial was to evaluate the efficacy of intraprocedural cerebral embolic protection (CEP) in reducing strokes among patients undergoing transfemoral TAVR for aortic stenosis.

Aortic valve

Aortic valve Aortic TAVR Stroke

Modified percutaneous coronary intervention-derived risk models (PARIS and CREDO-Kyoto integer scoring systems) applied to Japanese transcatheter aortic valve replacement patients

Open Heart

JANUARY 19, 2023

Objective Postprocedural ischaemic and bleeding risks after transcatheter aortic valve replacement (TAVR) remain a major concern. Ischaemic events were defined as myocardial infarction, stroke, transient ischaemic attack or peripheral embolism at 1 year.

Aortic valve

Aortic valve TAVR Aortic Myocardial Infarction

InterAtrial Block

EMS 12-Lead

AUGUST 25, 2024

Examples of cardio embolic stroke etiology include: 1. Atrial Fibrillation 2. Cardiomyopathy with mural thrombus 3. Patent Foramen Ovale 4. Severe calcific Aortic (valve) Stenosis 5. Mechanical prosthetic valve Severe carotid artery stenosis is also implicated in embolic stroke.

AFIB

AFIB Embolism Atrial Fibrillation RN

Abstract 4140882: Peak Stroke Incidence Following Left Atrial Appendage Closure

Circulation

NOVEMBER 11, 2024

A fib is a well-established risk factor for ischemic strokes. In patients with nonvalvular A fib, the majority of embolic strokes are caused by thrombi development in the left atrial appendage. Systemic anticoagulation (AC) is effective in reducing stroke risk in patients with A fib. 5,661 underwent percutaneous closure.

Stroke

Stroke Strokes Aortic valve Document

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

FEBRUARY 29, 2024

24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24

Aortic valve

Aortic valve Myocardial Infarction Aortic Blood Pressure

Abstract 4146431: Acute Brain Attack: Peering Through The Esophageal Window In Cryptogenic Ischemic Stroke

Circulation

NOVEMBER 11, 2024

While intracardiac cardiac tumors and shunts are infrequent and typically asymptomatic, their existence can precipitate severe outcomes, including stroke, myocardial infarction and sudden death.Case Description:A 69-year-old female presented with left sided facial droop, slurred speech and left arm weakness.

Stroke

Stroke Strokes Aortic valve Myocardial Infarction

The efficacy of different types of cerebral embolic protection device during transcatheter aortic valve implantation: a meta-analysis

Frontiers in Cardiovascular Medicine

FEBRUARY 22, 2024

Aims Perioperative stroke remains a devastating complication after transcatheter aortic valve implantation (TAVI), and using a cerebral embolic protection device (CEPD) during TAVI may reduce the occurrence of stroke according to some studies. The risk of stroke was lower in the CEPD group: RR 0.68, 95% CI 0.49–0.96,

Aortic valve

Aortic valve Embolism Aortic Stroke

Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation

Open Heart

JANUARY 29, 2024

Aim To assess outcomes after cardiac surgery with biological valve replacement, valve repair or transcatheter aortic valve implantation (TAVI) in patients with atrial fibrillation (AF) in accordance with oral anticoagulant (OAC) treatment.

Atrial Fibrillation

Atrial Fibrillation Aortic valve Embolism Aortic

Impact of porcelain aorta on outcomes in transfemoral aortic valve implantation (TAVI) with balloon-expandable valves

Open Heart

JANUARY 30, 2025

Background Current guidelines recommend transcatheter aortic valve implantation (TAVI) for patients with aortic stenosis and porcelain aorta (PA). Our aim was to compare outcomes, including stroke and mortality, in well-matched patients with and without PA who received BEV during transfemoral TAVI procedures.

Aortic valve

Aortic valve Aortic Outcomes Academic

Brain-Protected TAVR Results in Fewer Real-World Disabling Strokes

No effect of cerebral embolic protection devices on stroke risk after TAVI

Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis

Webinars

Cerebral Embolic Protection for TAVI Doesn't Cut Strokes, Trial Affirms

Cerebral Embolic Protection Devices in Transcatheter Aortic Valve Implantation: Meta‐Analysis With Trial Sequential Analysis

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation

Role of Cerebral Embolic Protection Devices in Patients Undergoing Transcatheter Aortic Valve Replacement: An Updated Meta?Analysis

Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement

Modified percutaneous coronary intervention-derived risk models (PARIS and CREDO-Kyoto integer scoring systems) applied to Japanese transcatheter aortic valve replacement patients

InterAtrial Block

Abstract 4140882: Peak Stroke Incidence Following Left Atrial Appendage Closure

American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

Abstract 4146431: Acute Brain Attack: Peering Through The Esophageal Window In Cryptogenic Ischemic Stroke

The efficacy of different types of cerebral embolic protection device during transcatheter aortic valve implantation: a meta-analysis

Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation

Impact of porcelain aorta on outcomes in transfemoral aortic valve implantation (TAVI) with balloon-expandable valves

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