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Is primary PCI superior to thrombolysis in the first hour of STEMI ? The fact of the matter is, at best, pPCI fights for equipoise in the first hour, but thrombolysis is a clear winner in moral, scientifc & holistic perspective, as it can be administered very early, at a fraction of cost ,independent of expertise and infrastructure.
A comparison of electrocardiographic changes during reperfusion of acute myocardialinfarction by thrombolysis or percutaneous transluminal coronary angioplasty. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardialinfarction. Am Heart J. 2000;139:430–436.
Timing of revascularization in patients with transient ST segment elevation myocardialinfarction: a randomized clinical trial. A comparison of electrocardiographic changes during reperfusion of acute myocardialinfarction by thrombolysis or percutaneous transluminal coronary angioplasty. Lemkes et al.
In my experience, all Wellens' with significant myocardialinfarction have evolution from type A waves to type B waves over 6-24 hours' time , so that the presence of type A or type B waves, I believe, are simply a matter of the timing of recording and the rapidity of evolution. Am Heart J (1989) 117 : pp 657-665. de Zwaan C.,
Electrocardiographic Manifestations: Acute posterior wall myocardialinfarction. Posterior myocardialinfarction: the dark side of the moon. New electrocardiographic criteria for posterior wall myocardial ischemia validated by percutaneous transluminal coronary angioplasty model of acute myocardialinfarction.
Acute MyocardialInfarction Due to Left Circumflex Artery Occlusion and Significance of ST-Segment Elevation. Impact of delay to angioplasty in patients with acute coronary syndromes undergoing invasive management: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. Marti D et al.
Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardialinfarction. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardialinfarction. Am Heart J. Am Heart J.
Immediate and early percutaneous coronary intervention in very high-risk and high-risk non-ST segment elevation myocardialinfarction patients. In the setting of evolving infarction — development of AIVR often heralds the onset of reperfusion ( following thrombolysis, acute angioplasty, or spontaneous reperfusion ).
Initial diagnostics indicated non-ST-elevation myocardialinfarction, leading to immediate intervention. A combination of balloon angioplasty, stent implantation, and intra-arterial thrombolysis with recombinant tissue plasminogen activator (rt-PA) was employed, resulting in significant thrombus reduction and improved coronary flow.
A comparison of electrocardiographic changes during reperfusion of acute myocardialinfarction by thrombolysis or percutaneous transluminal coronary angioplasty. Electrocardiographic diagnosis of reperfusion during thrombolytic therapy in acute myocardialinfarction. Am Heart J 2000;139(3):4306.
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