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The ORBITA-2 trial ( NCT03742050 ) investigated the efficacy of Percutaneous Coronary Intervention (PCI) compared to placebo in 301 patients with stable angina. At the 12-week mark, the PCI group exhibited a significantly lower mean angina score (2.9) compared to the placebo group (5.6; odds ratio, 2.21; 95% CI, 1.41-3.47;
Background Refractory angina (RA) is a chronic condition characterized by the presence of debilitating angina symptoms due to established reversible ischemia in the presence of obstructive coronary artery disease (CAD).
The perplexing landscape of angina with nonobstructive coronary arteries (ANOCA) encompasses diverse pathophysiological entities, including coronary microvascular disease (CMD), coronary artery spasm, and the enigmatic myocardial bridging (MB). Original article: Sinha A et al.
Results from the open label roll-in cohort of patients having chronic myocardial ischemia with refractory angina showed an average increase in exercise tolerance of 107 seconds and an average of 82% reduction in angina episodes at the primary six-month follow-up endpoint compared to before receiving the study treatment.
In the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial, researchers examined the risk of ischemic events in patients with stable coronary artery disease. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram.
Co-prescribing potency drugs such as Viagra and organic nitrates for angina is associated with a 35% to 40% increased risk of death and about 70% higher risk of heart attack and heart failure. The Swedish researchers are now urging caution.
The primary outcome was a composite of death from any cause, myocardial infarction, or hospitalization for unstable angina at 2 years. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The analysis composed of participants with multivessel or left main CAD.
Coronary artery calcification is commonly found in patients with type 2 diabetes mellitus (T2DM), which may compromise the diagnostic accuracy of coronary computed tomography angiography (CTA). Computed tomogr.
The impact of this narrowing can ultimately result in angina (chest pain), which has been shown to double the risk of major cardiovascular events,1 as well as myocardial infarction ( heart attack ) or even death. Use Heart to Act on Angina. For more information: www.gehealthcare.com References: 1 World Health Federation.
Whether stenting a narrowed coronary artery improves symptoms such as chest pain (angina) or shortness of breath is a very different question. Share Angina The classic definition of angina involves the sensation of tightness in the centre of the chest that is brought on with exertion and is relieved with rest. The result?
The disease can cause a variety of symptoms, including heart failure, arrhythmias, peripheral embolism, dysautonomia, angina with normal coronary arteries, and others. The aim of this thematic collection is to gather high-quality articles that contribute to the advancement of knowledge about cardiac amyloidosis.
Differences in QoL (measured using the EuroQol Research Foundation instrument) and HRU between patients in rural and urban settings were evaluated in this post hoc analysis. to 1.00, p=0.04); ERR=0.84 (95% CI, 0.78 to 0.92, p<0.001); ERR=0.86 (95% CI, 0.81 to 0.92, p<0.001), respectively).
DECISION-CTO,EURO-CTO,EXPLORE,IMPACTOR) Opening a CTO, for reasons other than angina (i.e. This has become a difficult area of research because it involves spending more time with the patient, and hence not studied much.
Researchers analyzed 840 REDUCE-IT participants (10.3% Researchers analyzed 840 REDUCE-IT participants (10.3% absolute risk reduction for experiencing a first composite primary event (18.7% vs. 28%) and had a “number needed to treat” to avoid a primary event of 11 patients.
However, the TACT2 results did not reveal any difference in the composite primary outcome of death from any cause, heart attack, stroke, coronary revascularization or hospitalization for unstable angina among people who received weekly edetate disodium-based infusions compared with those who received a placebo. Gervasio A.
After enrolment, patients are followed with Seattle Angina Questionnaires and follow-up PET scans in patients with an initially abnormal PET scan and for cardiovascular events in 10 years. Ethics and dissemination Ethical approval was obtained from Danish regional committee on health research ethics.
Five highly-anticipated late-breaking clinical trial sessions, an ACC/AHA guidelines update session and a host of featured clinical research sessions have been announced by program planners for the American College of Cardiology’s 73 rd Annual Scientific Session & Expo to be held April 6-8 in Atlanta, GA.
The primary endpoint consisted of a composite of all-cause mortality, MI, stroke, coronary revascularization, or hospitalization for unstable angina. The primary superiority endpoint was clinically relevant bleeding (Bleeding Academic Research Consortium [known as BARC] types 2, 3, or 5). of patients in the PCI group compared to 3.4%
The favorable efficacy of CHM was primarily presented on five main conditions, coronary artery disease, hypertension, heart failure, restenosis, and angina pectoris. Nevertheless, the magnitude of the effect requires further investigation as the lack of relevant research and the complexity of the clinical practice of CHM.
Sympathectomy or spinal cord stimulation for the treatment of angina pectoris, as well as cardiac sympathetic denervation for the treatment of long QT syndrome associated with malignant ventricular arrhythmias, have been available and performed for more than half a century.
Objectives There are few reports regarding the prognosis in patients with obstructive coronary artery disease (OCAD) and vasospastic angina (VSA). This study investigated the clinical characteristics and clinical outcomes in patients with VSA and OCAD, especially regarding provoked spasm phenotypes and sites.
Background:The impact of antianginal therapies on the health status of coronary artery disease (CAD) patients who have undergone coronary revascularization has not been extensively researched. Methods:We analyzed data from 1,556 patients enrolled in the GREAT Disease Registry Study (Clinicaltrial No.
Background Cardiac 15O-water PET is a noninvasive method to evaluate epicardial and microvascular dysfunction and further quantitate absolute myocardial blood flow (MBF).
After percutaneous coronary intervention, DAPT was given for 1 month to patients presenting with stable angina. The primary end point was a composite of cardiac death, myocardial infarction, or stent thrombosis up to 1 year (Academic Research Consortium definite and probable). presented with acute coronary syndrome; 33.7%
In cardiovascular research, serotonin has been implicated in modulating vascular tone, platelet aggregation, and myocardial function. Further research is warranted to confirm these findings and to understand the underlying mechanisms. Circulation, Volume 150, Issue Suppl_1 , Page A4141170-A4141170, November 12, 2024.
Reflective of the critical role that inflammation plays in the formation, progression and rupture of atherosclerotic plaques, research into immune mechanisms of CVD has led to the identification of a range of therapeutic targets that are the subject of ongoing clinical trials.
The patient was given aspirin, heparin, morphine, and ondansetron and and transferred to a PCI-capable facility for a diagnosis of "unstable angina" with dynamic ECG changes. Circulation Research , 56 (2), 184–194. & Lukas, A. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Bardoner, J.
For the phase 2 trial, researchers enrolled 67 patients treated for nonobstructive HCM at 14 centers. At the end of this period, the researchers found no significant difference in the rate of adverse events among the two study groups, indicating the drug was not associated with any increased risk of adverse events.
Methods We retrospectively enrolled 237 patients who underwent elective coronary angiography (CAG) for stable angina or positive stress test results >1 year after CABG. Uric acid to albumin ratio (UAR) is a new marker which associated with cardiovascular mortality. We aim to evaluate the relationship between the SVGD and UAR.
Prior Indications in the U.S.: To reduce the risk of myocardial infarction, stroke, and unstable angina requiring hospitalization in adults with established cardiovascular disease. As an adjunct to diet, alone or in combination with other LDL-C lowering therapies in adults with primary hyperlipidemia, including HeFH, to reduce LDL-C. .”
7 Research has shown inflammation plays a significant role in the development of atherosclerosis and ASCVD,8-10 and even the formation of plaque.11 The benefit was most significant in reducing the incidence of stroke and angina requiring revascularization.35 35 Overall, the magnitudes of benefit seen from colchicine, 0.5
It was compared with N-terminal pro–B-type natriuretic peptide (NT-proBNP), peak troponin T-us value GRACE (Global Registry of Acute Coronary Events), CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology and American Heart Association guidelines (..)
(Session 511) Practice-Change Late-breakers ACC24 will offer practice-changing science that will be offered throughout the meeting, including late breaking-clinical trials as well as featured clinical research. EMPACT-MI—takes a look at empagliflozin applied to MIs instead of heart failure.
Angiographic and clinical characteristics of patients with unstable angina showing and ECG pattern indicating critical narrowing of the proximal LAD coronary artery. Evidence for Wellens as a reperfusion syndrome To my knowledge, there is no research paper demonstrating this. Am Heart J. 1982 Apr;103(4 Pt 2):730-6. de Zwaan C et al.
There are only a few elite academic trialist groups capable of running large trials and there’s ample reason to be suspicious about the nexus that has developed between academia and the pharmaceutical companies that shower them with cash to hopefully get a positive study result and pay off the pharmaceutical research investment manifold.
Takotsubo is a sudden event, not one with crescendo angina. 9 This dissociation between the degree of stenosis and the propensity to provoke an acute coronary syndrome helps to explain why myocardial infarction often occurs without being heralded by the demand-induced symptoms of angina that would result from a high-grade stenosis.
She has done quite a bit of research on the topic. Prog- nostic impact of spontaneous coronary artery dissection in young female patients with acute myocardial infarction: a report from the Angina Pecto- ris-Myocardial Infarction Multicenter Investigators in Japan. Int J Cardiol. 2016;207:341–348. doi: 10.1016/j.ijcard.2016.01.188.
Limiting sodium intake is a fundamental lifestyle modification shown to reduce the likelihood of subsequent major adverse cardiovascular events, researchers said. Researchers estimated sodium intake based on questionnaires in which participants were asked to report everything they had consumed in 24 hours. “To
For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. However, it remains unclear whether these lower referral rates for women stem from physician bias, disparities in baseline clinical status, or differences in the extent of coronary artery disease. EuroIntervention.
The study assessed the prevalence of CVD (heart attack, angina pectoris, coronary heart disease, other heart conditions, or stroke) and LE8 risk factors: insufficient physical activity (PA), nicotine exposure, sleep duration, obesity, physician-diagnosed high cholesterol, diabetes, and hypertension.
vs. 6.4%), and Black patients were more likely to be readmitted for angina (34.0 5.03] was associated with an increased risk of readmission for angina, while female sex was associated with decreased odds of repeat angiography (OR, 0.36; 95% CI, 0.14–0.90) Men were significantly more likely to have repeat angiography (13.7 vs. 19.1%).
In a study published by the American Heart Association, “Sex and Age Differences in the Association of Depression With Obstructive Coronary Artery Disease and Adverse Cardiovascular Events,” researchers investigated 3,237 patients (35% women) undergoing coronary angiography to evaluate for coronary artery disease (CAD).
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