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Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heartattack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4
LDL floats around in the blood stream and is thought to incrementally accumulate on blood vessels in the body, ultimately increasing the risk of heartattacks and strokes. The positive results described were driven almost entirely by fewer heartattacks, and fewer revascularization procedures in the evolucumab arm.
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