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The commonest causes of MINOCA include: atherosclerotic causes such as plaque rupture or erosion with spontaneous thrombolysis, and non-atherosclerotic causes such as coronary vasospasm (sometimes called variant angina or Prinzmetal's angina), coronary embolism or thrombosis, possibly microvascular dysfunction.
Given her lack of risk factors for coronary disease, and the fact that she was a 53 year old woman with compatible history and echo findings, stress cardiomyopathy rose to the top of my differential. Of course, stress cardiomyopathy is a diagnosis of exclusion. But not all OMI is atherosclerotic in nature.
by making it clear to everyone that this is NOT an EKG that one sees with takotsubo cardiomyopathy. Takotsubo is a sudden event, not one with crescendo angina. The impact of ST-segment elevation on the prognosis of patients with Takotsubo cardiomyopathy. An angiogram is a "lumenogram;" most plaque is EXTRALUMINAL!!
She had some very minor plaque but certainly nothing that could explain the heart attack and therefore she was discharged with a diagnosis of MINOCA i.e Then I think it is important that patient has an assessment of the function of the heart by means of an ultrasound to look for cardiomyopathies, Takotsubo etc.
Troponins may be negative with very rapid reperfusion, or measured too late, or chronically elevated due to cardiomyopathy or renal failure. Angiograms may be negative due to spasm or thrombus lysis or small vessel disease, or it may be a type 2 MI. SCAD occurs in patients with few or non-traditional cardiovascular risk factors. 2016.01.188.
If our valves are leaky then again, a smaller volume of blood is effectively ejected because some leaks back Cardiomyopathies – if the heart muscle itself is defective in some way then that makes it weaker. This includes conditions like familial hypertrophic cardiomyopathy, familial dilated cardiomyopathy etc.
Patients receiving semaglutide showed a greater change in Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary scores at 52 weeks than placebo. The primary endpoint consisted of a composite of all-cause mortality, MI, stroke, coronary revascularization, or hospitalization for unstable angina. in the medical therapy group.
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