article thumbnail

Endothelial SMAD4 Deficiency Promotes Pulmonary Hypertension by Impairing Cell Adhesion and Extracellular Matrix Organization

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Aberrant BMPR2 (bone morphogenetic protein receptor 2) signaling is associated with the pathogenesis of pulmonary hypertension. By contrast, mice with smooth muscle cell-specificSmad4deletion had no pulmonary hypertension but rather displayed evident aortic aneurysm and dissection.

article thumbnail

How High Blood Pressure Affects Your Heart and What You Can Do About It

MIBHS

High blood pressure, also known as hypertension, is a common condition that affects millions of people worldwide. Often referred to as the silent killer, hypertension can quietly damage your heart and other vital organs over time. Hypertension is diagnosed when blood pressure consistently reads 130/80 mm Hg or higher.

article thumbnail

An accessory renal aneurysm in a patient with absent renal artery: a case report

Frontiers in Cardiovascular Medicine

IntroductionThis study reports a patient who developed a secondary renal artery aneurysm (RAA) after occlusion of the main renal artery.MethodsA 25-year-old woman was hospitalized due to an enlarged renal artery aneurysm (RAA). The left kidney function remained normal, allowing successful aneurysm embolization.

article thumbnail

Case Report: Combined transcatheter arterial embolization and aortic stent-graft have better efficacy for bronchial artery aneurysms

Frontiers in Cardiovascular Medicine

Bronchial artery aneurysm (BAA) is a rare and fatal condition that requires immediate treatment. In the present case, a 76-year-old hypertensive woman was admitted with dizziness and diagnosed with an unruptured bronchial artery aneurysm, which was treated by transcatheter arterial embolization and aortic stent-graft.

article thumbnail

PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Recent studies show that hyperactivation of mTOR (mammalian target of rapamycin) signaling plays a causal role in the development of thoracic aortic aneurysm and dissection. Modulation of PP2A (protein phosphatase 2A) activity has been shown to be of significant therapeutic value.

article thumbnail

Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm.

article thumbnail

Pulmonary Edema, Hypertension, and ST Elevation 2 Days After Stenting for Inferior STEMI

Dr. Smith's ECG Blog

Furthermore, the patient has no chest pain (certainly many STEMI do not have chest pain, but it should always make you especially scrutinize the ECG and the clinical situation) and there was severe hypertension. The hypertension alone is the likely etiology of the pulmonary edema. The cath lab was activated.

STEMI 52