Aneurysm, Hemorrhage and Ischemia - Cardiovascular Update

Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

JANUARY 30, 2025

Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice (DCI) with SAH. nucleosome.

Aneurysm

Aneurysm Biomarkers Ischemia Hemorrhage

ECG Changes in Intracranial Hemorrhage

All About Cardiovascular System and Disorders

NOVEMBER 16, 2023

ECG Changes in Intracranial Hemorrhage ECG changes are fairly common in intracranial hemorrhage. Giant T inversions with QT interval prolongation may be seen in intracranial hemorrhage even without associated myocardial damage [1]. But the number of persons with lobar hemorrhage in that study was only 17%. Am Heart J.

Hemorrhage

Hemorrhage Myocardial Infarction Aneurysm Electrocardiogram

Secondary Ischemia Assessment in Murine and Rat Preclinical Subarachnoid Hemorrhage Models: A Systematic Review

Journal of the American Heart Association

FEBRUARY 29, 2024

BackgroundDelayed cerebral ischemia represents a significant contributor to death and disability following aneurysmal subarachnoid hemorrhage. In murine studies (n=30), the endovascular perforation model was predominantly used, while rat studies primarily employed intracisternal blood injection to mimic subarachnoid hemorrhage.

Ischemia

Ischemia Hemorrhage Blood Pressure Aneurysm

Clinical Outcomes of Diffuse Angiogram?Negative Subarachnoid Hemorrhage Versus Aneurysmal Subarachnoid Hemorrhage: A Propensity Score?Matched Analysis

Journal of the American Heart Association

DECEMBER 29, 2023

BackgroundThe outcome of diffuse angiogram‐negative subarachnoid hemorrhage (dan‐SAH) compared with aneurysmal SAH (aSAH) remains unclear. 60.12];P=0.042), or delayed cerebral ischemia (12.3% 4.64];P<0.001), presence of intraventricular hemorrhage (OR, 3.58 [95% CI, 1.72–7.46];P=0.001), 18.95];P=0.045).

Hemorrhage

Hemorrhage Aneurysm Outcomes Ischemia

Abstract WP370: Platelet morphology but not coagulation markers predicts delayed cerebral ischemia after subarachnoid hemorrhage

Stroke Journal

JANUARY 30, 2025

Approximately 30% of aneurysmal subarachnoid hemorrhage (aSAH) patients who survive the rupture develop delayed cerebral ischemia (DCI) 4 to 10 days following aSAH. Stroke, Volume 56, Issue Suppl_1 , Page AWP370-AWP370, February 1, 2025.

Ischemia

Ischemia Hemorrhage Biomarkers Aneurysm

Abstract 114: LACROSSE Trial: Lumbar Drainage Compared to External Ventricular Drainage in Aneurysmal Subarachnoid Hemorrhage, a Randomized Control Trial

Stroke Journal

FEBRUARY 1, 2024

Introduction:Delayed cerebral ischemia (DCI) is a leading cause of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH). There was no significant difference between the two arms with regards to admission characteristics, aneurysm location, treatment type, or total number of vasospasm treatments.

Aneurysm

Aneurysm Hemorrhage ICU Ischemia

Abstract WMP112: Neutrophil Extracellular Traps Occlude the Cerebrovasculature Causing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice

Stroke Journal

FEBRUARY 1, 2024

Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). In this study, our hypothesis was that NETs cause vascular occlusion leading to delayed cerebral ischemia (DCI) and worse outcome after SAH. Similar findings were observed for PAD4 inhibition.

Ischemia

Ischemia Hemorrhage Aneurysm Outcomes

Abstract WP152: Association Between Cerebrospinal Fluid Interleukin-6 Levels and Cerebral Autoregulation After Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Introduction:Elevated levels of Interleukin-6 (IL-6) levels in cerebrospinal fluid (CSF) have been correlated with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Stroke, Volume 55, Issue Suppl_1 , Page AWP152-AWP152, February 1, 2024.

Aneurysm

Aneurysm Hemorrhage Ischemia Strokes

Comparison of Angiographic Outcomes of Woven EndoBridge and Balloon?Assisted Coiling for the Treatment of Ruptured Wide?Necked Aneurysms: A Multicentric Study

Stroke: Vascular and Interventional Neurology

FEBRUARY 15, 2024

BACKGROUNDThe optimal endovascular approach for acutely ruptured wide‐neck intracranial aneurysms remains uncertain, and the use of stent‐assisted coiling or flow diversion is controversial due to antiplatelet therapy requirements and potential risks. P= 0.180) and hemorrhagic events (WEB: 3.8% versus BAC: 2.8%;P= versus BAC: 7.5%;P=

Aneurysm

Aneurysm Outcomes Hemorrhage Stent

Abstract 039: Angiographic Outcomes of Woven EndoBridge and Balloon?Assisted Coiling for the Treatment of Ruptured Wide?Necked Aneurysms

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionThe optimal endovascular approach for wide‐neck intracranial aneurysms (IAs) during the acute phase of bleeding remains uncertain, and the use of stent‐assisted coiling or flow diversion is controversial due to antiplatelet therapy requirements and potential risks (1, 2).

Aneurysm

Aneurysm Outcomes Hemorrhage Stent

Abstract TP169: Cannabidiol as a Therapy for Experimental Subarachnoid Hemorrhage

Stroke Journal

FEBRUARY 1, 2024

Subarachnoid hemorrhage (SAH), commonly caused by a ruptured aneurysm, carries a high rate of disability and death. Preclinical studies demonstrate SAH induces dysregulation of the cerebrovasculature and increases neuroinflammation, which contributes to early brain injury and delayed cerebral ischemia.

Hemorrhage

Hemorrhage Ischemia Aneurysm Strokes

Tachycardia must make you doubt an ACS or STEMI diagnosis; put it all in clinical context

Dr. Smith's ECG Blog

OCTOBER 26, 2010

More often, tachycardia with ST segment abnormalities (elevation or depression) is due to an underlying illness (PE, sepsis, hemorrhage, dehydration, hypoxia, respiratory failure, etc.). Then ACS (STEMI) might be primary; this might be cardiogenic shock. One must clearly rule out these processes before jumping on the ACS diagnosis.

STEMI

STEMI Cardiogenic Shock Tachycardia Aneurysm

Middle Aged Woman with Asystolic Cardiac Arrest, Resuscitated: Cath Lab?

Dr. Smith's ECG Blog

OCTOBER 20, 2013

This ECG is diagnostic of diffuse subendocardial ischemia. Because the patient had asystole, was resuscitated without difficulty, and had no neurologic function, suspected a cerebral hemorrhage was suspected as the etiology of the arrest, specifically subarachnoid hemorrhage. What is the utility of a head CT in cardiac arrest?

Cardiac Arrest

Cardiac Arrest STEMI Hemorrhage Hospital

Abstract WP192: Impact of Second Line Thrombectomy Technique Following Failed First Pass Thrombectomy for Anterior Circulation Stroke: To Switch or Not to Switch?

Stroke Journal

FEBRUARY 1, 2024

Methods:This was a retrospective observational study using data from the large multicenter international Stroke Thrombectomy and Aneurysm Registry (STAR). The primary outcome measure was successful recanalization defined as modified Thrombolysis in Cerebral Ischemia (mTICI) score of 2b or higher.

Circulation

Circulation Strokes Stroke Thrombolysis

Abstract WP26: Determinants of Neuropsychological Function after Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

JANUARY 30, 2025

Introduction:Aneurysmal subarachnoid hemorrhage (aSAH) survivors suffer cognitive and behavioral challenges preventing their return to work and social activities. Clinical variables, modified Rankin score (mRS) at discharge, hemorrhage volume, and the occurrence of vasospasm or new ischemia during hospitalization were collected.

Hemorrhage

Hemorrhage Aneurysm Quality of Life Ischemia

Abstract TP153: Review of Hospital Outcomes for Aneurysm Securement in SAH at a Midwest Comprehensive Stroke Center

Stroke Journal

JANUARY 30, 2025

Background:According to the 2023 guidelines for the management of patients with aneurysmal subarachnoid hemorrhages (SAH), early treatment of ruptured aneurysms reduces the risk of repeated bleeds and facilitates treatment of delayed cerebral ischemia. No differences were noted in the size or location of aneurysm.

Aneurysm

Aneurysm Hospital Outcomes Strokes

Emergency Department Syncope Workup: After H and P, ECG is the Only Test Required for Every Patient.

Dr. Smith's ECG Blog

APRIL 8, 2015

Look for Vascular Etiology -- think of these while doing H and P: --Bleeding: ruptured AAA, GI bleed, ruptured ectopic pregnancy, other spontaneous bleed such as mesenteric aneurysms. Also consider non-hemorrhagic volume depletion, dehydration : orthostatic vitals may uncover this [see Mendu et al. (3)]. Left BBB vi. LVH or RV d.

Arrhythmia

Arrhythmia Outcomes Risk Factors Chest Pain

Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

ECG Changes in Intracranial Hemorrhage

Secondary Ischemia Assessment in Murine and Rat Preclinical Subarachnoid Hemorrhage Models: A Systematic Review

Clinical Outcomes of Diffuse Angiogram?Negative Subarachnoid Hemorrhage Versus Aneurysmal Subarachnoid Hemorrhage: A Propensity Score?Matched Analysis

Abstract WP370: Platelet morphology but not coagulation markers predicts delayed cerebral ischemia after subarachnoid hemorrhage

Abstract 114: LACROSSE Trial: Lumbar Drainage Compared to External Ventricular Drainage in Aneurysmal Subarachnoid Hemorrhage, a Randomized Control Trial

Abstract WMP112: Neutrophil Extracellular Traps Occlude the Cerebrovasculature Causing Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice

Abstract WP152: Association Between Cerebrospinal Fluid Interleukin-6 Levels and Cerebral Autoregulation After Aneurysmal Subarachnoid Hemorrhage

Comparison of Angiographic Outcomes of Woven EndoBridge and Balloon?Assisted Coiling for the Treatment of Ruptured Wide?Necked Aneurysms: A Multicentric Study

Abstract 039: Angiographic Outcomes of Woven EndoBridge and Balloon?Assisted Coiling for the Treatment of Ruptured Wide?Necked Aneurysms

Abstract TP169: Cannabidiol as a Therapy for Experimental Subarachnoid Hemorrhage

Tachycardia must make you doubt an ACS or STEMI diagnosis; put it all in clinical context

Middle Aged Woman with Asystolic Cardiac Arrest, Resuscitated: Cath Lab?

Abstract WP192: Impact of Second Line Thrombectomy Technique Following Failed First Pass Thrombectomy for Anterior Circulation Stroke: To Switch or Not to Switch?

Abstract WP26: Determinants of Neuropsychological Function after Aneurysmal Subarachnoid Hemorrhage

Abstract TP153: Review of Hospital Outcomes for Aneurysm Securement in SAH at a Midwest Comprehensive Stroke Center

Emergency Department Syncope Workup: After H and P, ECG is the Only Test Required for Every Patient.

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