Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionSubarachnoid hemorrhage (SAH) has an estimated prevalence of 7.9 It is primarily caused by the rupture of intracranial aneurysms, leading to severe consequences and a 60% 6‐month mortality rateii. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. per 100,000 person yearsi.

Aneurysm 40

Aneurysm Hemorrhage Hypertension Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Background:While predictors of seizure in aneurysmal subarachnoid hemorrhage (aSAH) patients have been explored, predictors for seizure in patients with angiogram-negative non-perimesencephalic SAH (an-NPSAH) are less understood. Neither intracerebral hemorrhage nor aneurysm securement modality was associated with seizure.

Aneurysm 40

Aneurysm Hemorrhage Academic Hospital 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionAneurysmal subarachnoid hemorrhage (aSAH) accounts for about 10% of hemorrhagic strokes [1] and holds a high mortality and morbidity rate. [2, Head CT on arrival showed a diffuse subarachnoid hemorrhage, more prominent in the posterior fossa, and grade IV on the modified Fisher scale.

Hemorrhage 40

Hemorrhage Aneurysm Atrial Fibrillation Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Some studies have shown that females had a poorer prognosis after endovascular treatment for ruptured intracranial aneurysm than males. The study presented intracranial aneurysms after microsurgical and/or endovascular treatment from January 1, 2013 to December 31, 2022. vs 35.7 %, 10.8 % vs 5.7%, and 28.2%

Aneurysm 40

Aneurysm Hemorrhage Outcomes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Delayed cerebral ischemia (DCI) is a leading cause of morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH). There was no significant difference between the two arms with regards to admission characteristics, aneurysm location, treatment type, or total number of vasospasm treatments.

Aneurysm 40

Aneurysm Hemorrhage ICU Ischemia 40

Stroke Journal

JANUARY 30, 2025

Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications. Stroke, Volume 56, Issue Suppl_1 , Page ATMP4-ATMP4, February 1, 2025.

Aneurysm 40

Aneurysm Hemorrhage Biomarkers Stroke 40

Hypertension Journal

JANUARY 2, 2024

BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm. Similarly, ER-stress inhibition also significantly decreased the rupture rate.

Aneurysm 45

Aneurysm Pharmacology Atherosclerosis Hemorrhage 45

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionIntracranial Aneurysm results from enlargement in the wall of a blood vessel in the brain, especially in the circle of Willis. It represents a high mortality and morbidity rate due to its risk of rupture causing Sub Arachnoid Hemorrhage which is a dangerous and life‐threatening condition. in Kenya and 44.4% in Nigeria.

Aneurysm 40

Aneurysm Hemorrhage Risk Factors Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Introductionintracranial dissecting aneurysm in pediatric age group is uncommon and very few studies are available comparing outcome following endovascular and surgery. years (range, 3–15 years), comprising 25% of all treated intracranial aneurysms in pediatric cases during the specified period.

Aneurysm 40

Aneurysm Pediatrics Outcomes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionFlow diversion (FD) has emerged as an effective treatment option for intracranial aneurysms (IAs). Patients harboring distal aneurysms of the posterior circulation including the PICA, AICA, SCA, and PCA P2‐3 treated with FD were included. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.

Aneurysm 40

Aneurysm Circulation Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Elevated levels of Interleukin-6 (IL-6) levels in cerebrospinal fluid (CSF) have been correlated with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Stroke, Volume 55, Issue Suppl_1 , Page AWP152-AWP152, February 1, 2024.

Aneurysm 40

Aneurysm Hemorrhage Ischemia Stroke 40

Stroke Journal

JANUARY 30, 2025

Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage. Conclusion:In this study, we demonstrated that radiomics from the aneurysm wall alone have a low predictive value in identifying symptomatic IAs. The LOO accuracy improved to 85.7% (66.6%

Aneurysm 40

Aneurysm Biomarkers Hemorrhage Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Ruptured aneurysmal subarachnoid hemorrhage accounted for 15.7% (8/51) of all patients. The most common aneurysm location in the present study was MCA bifurcation (52.9%). The median maximal aneurysm diameter was 6.9mm, while the median neck size was 4.4mm. Retreatment was required in 1 aneurysm.

Aneurysm 40

Aneurysm Embolism Hemorrhage Document 40

Stroke Journal

FEBRUARY 1, 2024

Iron-induced oxidative stress triggers lipid oxidation, inflammation, endothelial cell activation and intracranial aneurysmal formation, growth, and rupture. Subarachnoid hemorrhage from intracranial aneurysm rupture results in significant morbidity and mortality. Mice were fed an iron-restricted diet or a normal diet.

Aneurysm 40

Aneurysm Diet Hemorrhage Hypertension 40

Stroke Journal

FEBRUARY 1, 2024

Background:Cerebral vasospasm is a well-known complication after aneurysmal subarachnoid hemorrhage (aSAH) and occurs more commonly in younger patients. Stroke, Volume 55, Issue Suppl_1 , Page AWP139-AWP139, February 1, 2024.

Atherosclerosis 40

Atherosclerosis Aneurysm Hemorrhage Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2024

BACKGROUNDAneurysmal subarachnoid hemorrhage (aSAH) is a major source of morbidity and mortality, and its management has undergone foundational changes over thepast 2 decades. Patients undergoing surgery to secure an aneurysm were more severely ill through time yet experienced a stable hospital mortality rate.

Inpatient 40

Inpatient Hemorrhage Aneurysm Hospital 40

Stroke Journal

JANUARY 30, 2025

Introduction:Aneurysmal subarachnoid hemorrhage (aSAH) carries high morbidity and mortality. Intraventricular hemorrhage (OR 0, 95% CI 0-1.12, p=0.043), tracheostomy (OR=0.14, 95% CI 0.14-1.01, Stroke, Volume 56, Issue Suppl_1 , Page ATP100-ATP100, February 1, 2025. Discharged patients were younger (mean 63.311.5 years vs. 70.29.3,

Nursing 40

Nursing Hemorrhage Aneurysm Hospital 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Introduction18‐36% of all intracranial aneurysms are middle cerebral artery(MCA) bifurcation aneurysms. 1) MCA bifurcation aneurysms have been historically challenging to treat endovascularly given they often have complex morphology and wide necks. Final angiography revealed complete occlusion of the aneurysm.

Aneurysm 40

Aneurysm Embolism Hemorrhage Stenosis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionCerebral aneurysms are a rare cause of headaches and visual symptoms. While most unruptured aneurysms are asymptomatic, when symptoms do occur, they are most often headaches, cranial nerve palsies, or bilateral temporal hemianopsia due to compression of surrounding nerves or the optic chiasm.

Aneurysm 40

Aneurysm Embolism Hemorrhage Hospital 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionFlow diverters have demonstrated reliable safety and effectiveness for the treatment of selected anterior circulation intracranial aneurysms. However, posterior circulation aneurysms comprise around 10‐15% of all aneurysms, and they frequently present atypical morphological and anatomical characteristics.

Aneurysm 40

Aneurysm Circulation Hemorrhage Outcomes 40

Stroke Journal

JANUARY 30, 2025

Steep intracranial pressure (ICP) rise constitutes a hallmark of aneurysmal subarachnoid hemorrhage (SAH). In the brain parenchyma, we observed minimal infiltration of circulating immune cells, consistent with the effects of aneurysm rupture. Stroke, Volume 56, Issue Suppl_1 , Page ATP397-ATP397, February 1, 2025.

Aneurysm 40

Aneurysm Hemorrhage Circulation Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Cerebral AVMs may manifest with new‐onset seizures or intraparenchymal (IPH) or subarachnoid hemorrhages (SAH). Life‐threatening bleeds may occur from the AVM nidus or associated aneurysms. Two large inflow aneurysms, felt to be the rupture site, projecting from the proximal left pericallosal artery were also demonstrated.

Aneurysm 40

Aneurysm Embolism Hemorrhage Hypertension 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionThe Pipeline Embolization Device (PED) is commonly used for intracranial aneurysm treatment. While its effectiveness for certain types of aneurysms is well‐established, its efficacy for saccular aneurysms remains debatable. The primary endpoint was angiographic complete aneurysm occlusion at long‐term (≥ 12 mo.)

Aneurysm 40

Aneurysm Outcomes Embolism Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. Stroke, Volume 56, Issue Suppl_1 , Page ATMP1-ATMP1, February 1, 2025.

Biomarkers 40

Biomarkers Aneurysm Cardiomyopathy Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Pregnancy is a risk factor for subarachnoid hemorrhage (SAH). We aim to better understand this risk and its impact on in-hospital outcomes over a longitudinal time period in a large population based sample.Methods:We analyzed the 2000-2019 National Inpatient Sample, selecting for aneurysmal SAH (aSAH).

Inpatient 40

Inpatient Aneurysm Hemorrhage Outcomes 40

Stroke: Vascular and Interventional Neurology

SEPTEMBER 12, 2023

BackgroundUnruptured cerebral aneurysms (UCAs) have a relatively low prevalence of ≈3%, but detection can prevent devastating consequences of subarachnoid hemorrhage. There were a total of 36 true aneurysms with 4 cases of multiple aneurysms. Overall, the most common locations included internal carotid artery (42%).

Aneurysm 40

Aneurysm Hemorrhage Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Both anticoagulants can be used intraoperatively and postoperatively for DVT prophylaxis in patients undergoing subarachnoid hemorrhage (SAH) treatment. This nationwide, multicenter, retrospective study provides valuable insights for clinicians on how to prevent and manage HIT in patients with subarachnoid hemorrhage.

Hemorrhage 40

Hemorrhage Aneurysm Outcomes Thrombosis 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 15, 2024

BACKGROUNDThe optimal endovascular approach for acutely ruptured wide‐neck intracranial aneurysms remains uncertain, and the use of stent‐assisted coiling or flow diversion is controversial due to antiplatelet therapy requirements and potential risks. P= 0.180) and hemorrhagic events (WEB: 3.8% versus BAC: 2.8%;P= versus BAC: 7.5%;P=

Aneurysm 40

Aneurysm Outcomes Hemorrhage Stent 40

Stroke Journal

JANUARY 30, 2025

Cerebrovascular conditions included brain or spine AVM, cavernous malformation, cerebral aneurysm, Moya-Moya vasculopathy, and/or unexplained hemorrhagic stroke. Individuals with perinatal or isolated arterial ischemic stroke were not included. Median age at testing was 14 years (range 2mo 24 years), and 11 (55%) were male.

Pediatrics 40

Pediatrics Hemorrhage Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:Flow diversion (FD) is a minimally invasive treatment for unruptured intracranial aneurysms (UIA) and is often preferred over open cerebrovascular surgery; however, FD patients are at risk of post-procedural stroke and hemorrhage. Among readmitted AMD patients without confirmed stroke or hemorrhage, 15.4%

Aneurysm 40

Aneurysm Hospital Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Cisternal score (CISCO), which is calculated based on quantification of blood clot in basal cisterns, has been shown to have good accuracy in predicting ventriculoperitoneal shunt requirement in patients with aneurysmal subarachnoid hemorrhage (aSAH).

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Blood Clot Aneurysm Hemorrhage Academic 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionIntracranial aneurysms, both ruptured and unruptured, pose a significant risk to the general population. Cases of unruptured intracranial aneurysms (UIA) are estimated to affect roughly 3% of the general population and aneurysmal subarachnoid hemorrhage (aSAH) have an incidence of 8 to 9 people per 100,000.

Aneurysm 40

Aneurysm Embolism Stent Stents 40

Stroke Journal

JANUARY 30, 2025

Background:Pediatric brain arteriovenous malformation (bAVM) patients often present with intracranial hemorrhage. While certain angioarchitectural features, such as aneurysms, deep venous drainage, a single draining vein, venous outflow stenosis, or small nidus size, increase hemorrhage risk, they do not fully predict it.

Hemorrhage 40

Hemorrhage Pediatrics Aneurysm Stenosis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

We present a case of subarachnoid hemorrhage (SAH) due to SCS lead migration into the subdural space.MethodsAn 81‐year‐old female patient with a past medical history of heart failure, atrial fibrillation and a mechanical mitral valve, presents with a severe headache and right hemiparesis.

Hemorrhage 40

Hemorrhage Aneurysm Atrial Fibrillation Bicuspid/Mitral 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Impact of race on outcomes in the treatment of intracranial aneurysm (IA) remains unclear. Data from 9 centers in the United States, Europe, and Asia for IA patients who undertook endovascular treatment (EVT) or microsurgical treatment (MST) between January 2016 and December 2020 were included for analysis.

Aneurysm 40

Aneurysm Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Background:Local angiotensin activity is thought to play a critical role in arterial wall homeostasis and remodeling, which contributes to the pathogenesis of subarachnoid hemorrhage (SAH). No difference in rate of SAH was observed in patients with intracerebral aneurysms who were treated by only ACEI antihypertensives [HR:1.03(0.93-1.13),p=0.59]

Hemorrhage 40

Hemorrhage Hypertension Aneurysm Pharmacology 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionThe optimal endovascular approach for wide‐neck intracranial aneurysms (IAs) during the acute phase of bleeding remains uncertain, and the use of stent‐assisted coiling or flow diversion is controversial due to antiplatelet therapy requirements and potential risks (1, 2).

Aneurysm 40

Aneurysm Outcomes Hemorrhage Stent 40