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Androgen aggravates aortic aneurysms via suppression of PD-1 in mice

Journal of Clinical Investigation - Cardiology

Androgen has long been recognized for its pivotal role in the sexual dimorphism of cardiovascular diseases, including aortic aneurysms (AAs), a devastating vascular disease with a higher prevalence and fatality rate in men than in women. However, the mechanism by which androgen mediates AAs is largely unknown.

Aneurysm 109
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How High Blood Pressure Affects Your Heart and What You Can Do About It

MIBHS

Increased Risk of Aneurysms : Chronic high blood pressure can weaken the walls of your arteries, leading to bulging areas known as aneurysms. If an aneurysm ruptures, it can cause life-threatening internal bleeding. Heart Failure : Over time, the extra strain on your heart can lead to its weakening and eventual failure.

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Abstract TMP114: The Role of Iron Mediated Oxidative Stress and Lipid Peroxidation in the Development of Intracranial Aneurysm Rupture

Stroke Journal

Iron-induced oxidative stress triggers lipid oxidation, inflammation, endothelial cell activation and intracranial aneurysmal formation, growth, and rupture. Subarachnoid hemorrhage from intracranial aneurysm rupture results in significant morbidity and mortality. Mice were fed an iron-restricted diet or a normal diet.

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Three Researchers Awarded $1 million Each to Study New Heart Disease Treatments, Causes

DAIC

Using this information, his team will then investigate ways to use these compounds to create diets that specifically protect against heart disease and lay the groundwork for developing new drugs that can be used for heart disease treatment. “One Smoking is a prevalent risk factor among people who have an abdominal aortic aneurysm.

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Why Your Time Here May Be Shorter Than You Think.

Dr. Paddy Barrett

The first is of Dr Michael Mosley, the BBC physician presenter who popularised a fasting-based diet and generally advocated for sound health-based approaches to cardiovascular health. The cause of this arterial rupture was very likely an aneurysm that had grown over time and ruptured. These aneurysms are rare. He survived.

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Abstract WMP116: A P2X4 Inhibitor Dramatically Suppresses the Progression of Cervical Internal Carotid Artery Stenosis - An Attempt to Develop a Therapeutic Agent for Carotid Artery Stenosis Focusing on the Role of Hemodynamic Factors-

Stroke Journal

Similarly, cerebral aneurysms are known to progress due to hemodynamic effects. We have shown in animal studies that inhibition of P2X4 purinoceptor, an endothelial blood flow sensing-related protein, significantly inhibits the development of cerebral aneurysms.