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The link between high blood pressure and aortic aneurysms

CTVS

An aortic aneurysm is a very serious condition that occurs when the aorta (the largest artery in the body that comes off the heart) develops a bulb-like formation. Factors such as high blood pressure and high cholesterol can… Source Factors such as high blood pressure and high cholesterol can… Source

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Abstract WMP116: A P2X4 Inhibitor Dramatically Suppresses the Progression of Cervical Internal Carotid Artery Stenosis - An Attempt to Develop a Therapeutic Agent for Carotid Artery Stenosis Focusing on the Role of Hemodynamic Factors-

Stroke Journal

Similarly, cerebral aneurysms are known to progress due to hemodynamic effects. We have shown in animal studies that inhibition of P2X4 purinoceptor, an endothelial blood flow sensing-related protein, significantly inhibits the development of cerebral aneurysms.

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Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G?Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease

Journal of the American Heart Association

The expression of GPBAR1 in the human endothelium correlated with the expression of inflammatory biomarkers. Vasomotor activities of aortic rings were altered byGpbar1andFxrgene ablation.

Aortic 40
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Three Researchers Awarded $1 million Each to Study New Heart Disease Treatments, Causes

DAIC

Blood lipids such as cholesterol and triglycerides are causal risk factors for coronary heart disease as well as several other types of cardiovascular disease , such as aortic stenosis). Smoking is a prevalent risk factor among people who have an abdominal aortic aneurysm.

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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3 Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials.

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Society for Vascular Surgery Launches Campaign to Help People Maintain Vascular Health

DAIC

Risk factors for vascular disease include having diabetes, use or history of tobacco products, high cholesterol, and/or high blood pressure. Key Survey Highlights ● Nearly 1 in 3 (29%) Americans have not heard of any of the most common vascular diseases, like peripheral artery disease, carotid artery disease, or abdominal aortic aneurysm.

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The serum uric acid/high-density lipoprotein cholesterol ratio: a novel predictor for the presence of abdominal aortic aneurysm

Frontiers in Cardiovascular Medicine

ObjectiveRobust evidence has demonstrated that inflammation plays an important role in the occurrence and development of abdominal aortic aneurysms (AAA). However, whether UHR is associated with AAA remains unclear.