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The Role of Long Non-Coding RNAs in Vascular Smooth Muscle Cell Phenotype and the Pathogenesis of Cardiovascular and Cerebrovascular Aneurysms

Journal of Cardiovascular Pharmacology

Aneurysms are localized dilations of blood vessels, which can expand to 50% of the original diameter. They are more common in cardiovascular and cerebrovascular vessels. Multiple studies have shown that long non-coding RNAs (lncRNAs) play a significant role in the progression of cardiovascular and cerebrovascular diseases.

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Abstract WP288: Epidemiological Analysis of Incidence, Treatment, Mortality and Costs of Cerebrovascular Diseases in Brazil Between 2017 and 2022

Stroke Journal

8290 aneurysms embolizations were performed (13.5% Data was obtained through DataSUS, a public database. Mortality percentages were: SAH=20.2%, ICH=25.3%, Ischemic Stroke=15.3%. Rates of Thrombolysis were alarming, but with an increasing tendency: 22969 were performed, from 1.6% in 2017 to 2.3% in 2022 of all ischemic strokes.

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Abstract 78: Evaluation of AneuScreenTM, a Blood-Based Gene Expression Diagnostic for Intracranial Aneurysm

Stroke Journal

Introduction:Intracranial aneurysm (IA), a cerebrovascular disease affecting 3-5% of US population, leads to subarachnoid hemorrage. Stroke, Volume 56, Issue Suppl_1 , Page A78-A78, February 1, 2025.

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Abstract TMP88: Clinical Utility of Genetic Testing in Pediatric and Young Adult Hemorrhagic Stroke and Cerebrovascular Malformations

Stroke Journal

Introduction:Pediatric and young adult cerebrovascular disease is more commonly associated with genetic conditions compared to in adults. Cerebrovascular conditions included brain or spine AVM, cavernous malformation, cerebral aneurysm, Moya-Moya vasculopathy, and/or unexplained hemorrhagic stroke.

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Abstract TP284: Transcriptome Profiling of Peripheral Blood Mononuclear Cells in Moyamoya Disease

Stroke Journal

Objectives:Moyamoya Disease (MMD) is a progressive occlusive cerebrovascular disease with unknown etiology and pathogenesis. Stroke, Volume 55, Issue Suppl_1 , Page ATP284-ATP284, February 1, 2024. Peripheral blood mononuclear cells (PBMCs) were isolated and cryopreserved.

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Abstract TP280: Monogenetic Stroke Syndrome Testing in Adults: A Single Center Experience

Stroke Journal

Tests ordered included whole exome sequencing, mitochondrial genome sequencing, Marfan syndrome and thoracic aortic aneurysm and dissection panel, Disorders of connective tissues panel and expedited whole genome sequencing.

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Abstract 023: Early Medical Student Introduction to Interventional Neurology: Integrating Neuroendovascular Simulation to Foster Engagement

Stroke: Vascular and Interventional Neurology

IntroductionInterventional Neurology (IN) is a rapidly expanding field, with new devices and techniques broadening the range of cerebrovascular diseases that can be treated (1). Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. All participants provided consent.