Remove Aneurysm Remove Biomarkers Remove Stroke
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Genetic Insights Into Hemorrhagic Stroke and Vascular Malformations: Pathogenesis and Emerging Therapeutic Strategies

Stroke Journal

Stroke, Ahead of Print. Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking.

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Abstract TMP1: Identification of True Biomarkers for Unruptured Cerebral Aneurysms through Revisiting Cerebral Aneurysm Transcriptomes

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATMP1-ATMP1, February 1, 2025. A cerebral aneurysm (CA) is an abnormal artery deformation in the brain that may lead to hemorrhagic stroke, brain damage, coma, and even death when a CA ruptures. We hypothesized that increasing CA sample size will allow more robust biomarker identification.

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Abstract TP377: A Biomarker Based on Aneurysm Wall Enhancement and Blood Gene Expression to Identify Symptomatic Intracranial Aneurysms

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATP377-ATP377, February 1, 2025. Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage. With the addition of the gene expression features, we found the PCA explained variance to be 41% and 26%.

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Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page AWP35-AWP35, February 1, 2025. In this study, our hypothesis was that markers of NETs are higher in aneurysmal SAH patients developing DCI compared to SAH patients not developing DCI. Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH).

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Clinical Scales in Aneurysm Rupture Prediction

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Ahead of Print. The rate of incidentally discovered unruptured intracranial aneurysms has increased with the broad availability of neuroimaging. The determination of the risk of rupture of brain aneurysms is challenging. The most common scales are PHASES, ELAPSS, and UIATS.

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Abstract TMP25: Common Molecular Biomarkers in Different Types of Acute Brain Injuries Predicting Outcome

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2024. Background:Acute brain injuries, including aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI), entail complex recovery processes involving brain plasticity and synaptic regeneration mechanisms.

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Abstract TMP4: Serum Protein Biomarekrs and Cell Suptypes Linked to Reduced Cerebral Edema in Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATMP4-ATMP4, February 1, 2025. Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications.