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Genetic Insights Into Hemorrhagic Stroke and Vascular Malformations: Pathogenesis and Emerging Therapeutic Strategies

Stroke Journal

Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Due to the genetic overlap, these advancements may also offer future therapeutic strategies for intracranial aneurysms.

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Single-cell RNA sequencing and ATAC sequencing identify novel biomarkers for bicuspid aortic valve-associated thoracic aortic aneurysm

Frontiers in Cardiovascular Medicine

IntroductionBicuspid aortic valve (BAV) is the most prevalent congenital cardiovascular defect and known to cause thoracic aortic aneurysms (TAAs).

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Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

In this study, our hypothesis was that markers of NETs are higher in aneurysmal SAH patients developing DCI compared to SAH patients not developing DCI. Using aneurysmal SAH patient blood collected at 1, 2, 4, 7, and 10 days post-SAH, we used ELISA kits to measure three markers of NETs: neutrophil elastase, citrullinated histone H3, and H3.1

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Abstract TP377: A Biomarker Based on Aneurysm Wall Enhancement and Blood Gene Expression to Identify Symptomatic Intracranial Aneurysms

Stroke Journal

Introduction:Intracranial aneurysms (IAs) are weak outpouchings on cerebral vessels that can rupture, causing subarachnoid hemorrhage. Timely and accurate risk stratification of IAs is paramount.Objective:Aneurysm wall enhancement (AWE) is a potential imaging biomarker for risk stratification. The LOO accuracy improved to 85.7% (66.6%

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Clinical Scales in Aneurysm Rupture Prediction

Stroke: Vascular and Interventional Neurology

The rate of incidentally discovered unruptured intracranial aneurysms has increased with the broad availability of neuroimaging. The determination of the risk of rupture of brain aneurysms is challenging. Several clinical scales for aneurysm rupture prediction have been developed.

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Abstract TMP25: Common Molecular Biomarkers in Different Types of Acute Brain Injuries Predicting Outcome

Stroke Journal

Background:Acute brain injuries, including aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI), entail complex recovery processes involving brain plasticity and synaptic regeneration mechanisms. Stroke, Volume 55, Issue Suppl_1 , Page ATMP25-ATMP25, February 1, 2024.

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Abstract TMP4: Serum Protein Biomarekrs and Cell Suptypes Linked to Reduced Cerebral Edema in Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

Introduction:Early brain injury (EBI), a complex collection of pathophysiological processes occurring within 72 hours aneurysmal subarachnoid hemorrhage (aSAH), is the key link connecting the initial event to the delayed and long-term complications.