article thumbnail

Abstract WP139: Impact of Intracranial Atherosclerosis Burden on Vasospasm Risk and Outcomes in Aneurysmal Subarachnoid Hemorrhage

Stroke Journal

Background:Cerebral vasospasm is a well-known complication after aneurysmal subarachnoid hemorrhage (aSAH) and occurs more commonly in younger patients. We hypothesized that intracranial atherosclerosis, which is seen predominantly in older patients, affects vasospasm risk in aSAH.

article thumbnail

Non-coronary atherosclerosis: a marker of poor prognosis in patients undergoing coronary artery bypass surgery

Frontiers in Cardiovascular Medicine

Introduction The presence of non-coronary atherosclerosis (NCA) in patients with coronary artery disease is associated with a poor prognosis. We have studied whether NCA is also a predictor of poorer outcomes in patients undergoing coronary artery bypass grafting (CABG).

article thumbnail

Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress

Hypertension Journal

BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm. Similarly, ER-stress inhibition also significantly decreased the rupture rate.

article thumbnail

Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis in Vascular Smooth Muscle Cells

Circulation

BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to prevent AAA progression and rupture are currently lacking. Circulation, Ahead of Print. Sphingolipid metabolism disorders are associated with the occurrence and development of AAA.

article thumbnail

Minimally Invasive Vascular Disease Treatments

CTVS

Common examples of vascular disease are aneurysms (a dangerous bulge in an artery wall), atherosclerosis (plaque buildup in the… Source Research shows that in recent years almost half of all adults in the United States have been living with heart disease, one of the most prominent forms of vascular disease.

article thumbnail

Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3 1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. 4 In the U.S.

article thumbnail

The role of transcription factors in the pathogenesis and therapeutic targeting of vascular diseases

Frontiers in Cardiovascular Medicine

KLF11 prevents aneurysm progression by inhibiting the apoptosis of VSMCs and enhancing their contractile function. The Krüppel-like family (KLF) TF family is widely recognized as the foremost regulator of vascular diseases.