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MEK inhibitors: a promising targeted therapy for cardiovascular disease

Frontiers in Cardiovascular Medicine

In this article, we first describe how ERK signaling contributes to preserving cardiovascular health. We then summarize current knowledge of the roles played by ERK in the development and progression of cardiac and vascular disorders, including atherosclerosis, myocardial infarction, cardiac hypertrophy, heart failure, and aortic aneurysm.

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1 hour of CPR, then ECMO circulation, then successful defibrillation.

Dr. Smith's ECG Blog

The patient's heart had significant recovery: Echo : Estimated LVEF 32%, apical wall motion abnormality with diastolic distortion (LV aneurysm), suggestive of old MI. If there is any evidence of atherosclerosis, modifiable CAD risk factors should be treated aggressively. It was uncertain whether this represented: 1. FFR can be useful.