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Endothelial SMAD4 Deficiency Promotes Pulmonary Hypertension by Impairing Cell Adhesion and Extracellular Matrix Organization

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Aberrant BMPR2 (bone morphogenetic protein receptor 2) signaling is associated with the pathogenesis of pulmonary hypertension. By contrast, mice with smooth muscle cell-specificSmad4deletion had no pulmonary hypertension but rather displayed evident aortic aneurysm and dissection.

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Case Report: Combined transcatheter arterial embolization and aortic stent-graft have better efficacy for bronchial artery aneurysms

Frontiers in Cardiovascular Medicine

Bronchial artery aneurysm (BAA) is a rare and fatal condition that requires immediate treatment. In the present case, a 76-year-old hypertensive woman was admitted with dizziness and diagnosed with an unruptured bronchial artery aneurysm, which was treated by transcatheter arterial embolization and aortic stent-graft.

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Protein Drug Targets for Abdominal Aortic Aneurysm and Proteomic Associations Between Modifiable Risk Factors and Abdominal Aortic Aneurysm

Journal of the American Heart Association

BackgroundAbdominal aortic aneurysm (AAA) is a severe aortic disease for which no pharmacological interventions have yet been developed. Journal of the American Heart Association, Ahead of Print. Colocalization analysis pinpointed 13 proteins with strong evidence of colocalization with AAA.

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Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:The pathophysiology of familial thoracic aortic aneurysm and dissection (TAAD) is linked to genetic variants that affect aortic components. These findings establish a genetic link between systolic hypertension and TAAD.

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PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Recent studies show that hyperactivation of mTOR (mammalian target of rapamycin) signaling plays a causal role in the development of thoracic aortic aneurysm and dissection. Echocardiography was performed to monitor the growth of the aortic root and ascending aorta.

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Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm.

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Abstract 4140451: Loss of Stem Cell Antigen-1 Worsens Aortic Remodeling in Angiotensin II-Induced Hypertension

Circulation

Partial- or total loss of Sca-1 expression exacerbated aortic GFP+CD31-CD45-cell expansion, compared to Sca1GFP [Sca1KI-/-32±7-fold change of vehiclevs.Sca1KI+/-39±9vs.Sca1GFP 5±1; n=11-13/group; p<0.0001], suggesting disinhibited progenitor responses. Partial- or total loss of Sca-1 worsened aortic dilation [Sca1KI-/-1.25±0.06

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