Remove AFIB Remove Embolism Remove Plaque
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Novartis Reclaims Anthos, Reenters Factor XI Race

CardiacWire

Novartis initially prioritized its treatments for heart failure and plaque-clogged arteries when it spun-off abelacimab but continued to monitor the Factor XI race, leading to its choice to take the baton back from Anthos.

AFIB 102
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A man in his 30s with cardiac arrest and STE on the post-ROSC ECG

Dr. Smith's ECG Blog

As in all ischemia interpretations with OMI findings, the findings can be due to type 1 AMI (example: acute coronary plaque rupture and thrombosis) or type 2 AMI (with or without fixed CAD, with severe regional supply/demand mismatch essentially equaling zero blood flow). CT angiogram showed extensive saddle pulmonary embolism.

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Noisy, low amplitude ECG in a patient with chest pain

Dr. Smith's ECG Blog

Then, part of the thrombus embolized into the LCx causing an inferoposterolateral OMI. (As As an aside, the LCx OMI is a type 2 event, since it is due to supply-demand mismatch from thrombus, and not due to atherosclerotic plaque rupture or erosion). This resulted in anterior/apical infarct and apical thrombus formation.