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These trials added weight to the evidence that supported the use of both angiotensin-converting enzyme inhibitors (ACEi) or ARBs in diabetic kidney disease and chronic kidney disease (CKD), particularly in patients with proteinuria.
6.9), 3 with comparative studies consistently demonstrating a better prognosis than for those who experience AMI associated with obstructive coronary artery disease. See "Prevention of cardiovasculardisease events in those with established disease (secondary prevention) or at very high risk".) Lindahl et al.
We need to do better if we want to majorly impact rates of cardiovasculardisease worldwide. Those in the lower blood pressure group will postpone the onset of cardiovasculardisease by over 5 years and extend their lifespan by over 4 years. High blood pressure is the leading cause of preventable death worldwide 1.
6.9), 3 with comparative studies consistently demonstrating a better prognosis than for those who experience AMI associated with obstructive coronary artery disease. See "Prevention of cardiovasculardisease events in those with established disease (secondary prevention) or at very high risk".) Lindahl et al.
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through and Out of the Body, and the Effects it Has on the Body When Taken With an ACEInhibitor or Angiotensin Receptor Blocker in Children with Chronic Kidney Disease and Proteinuria (FIONA). NCT05196035. 1):S179-S218.
But the rising trends of obesity, diabetes, and cardiovasculardisease and the falling trend of activity levels lead me to a dark conclusion: things probably aren’t going to get any better. ACEinhibitors block the angiotensin-converting enzyme to reduce blood pressure. Statins lower cholesterol. Nor should it be.
Many of the commonest and most deadly diseases afflicting humanity would be picked up early, then treated. People at risk of cardiovasculardisease would have their cholesterol levels checked. Almost entirely by using medications which had proven benefits. Then, if high, put on statins. Other drugs to be added as required.
While subsequent works have shown that folic acid is not prognostically beneficial in preventing cardiovasculardisease, 2 and that aspirin may not be beneficial overall in primary prevention settings, 3 the concept of the combination pill was awakened in the public eye.
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