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The PROACT study reported no impact on cardiotoxicity biomarkers or secondary endpoints related to heart function among patients who took high doses of enalapril, an ACEinhibitor, along with high doses of anthracyclines. Anthracyclines are a well-established class of cancer drugs that are used to treat several types of cancer.
A key source of endothelial stress is treatment with tyrosine kinase inhibitors (TKIs), which lowers cancer mortality but increases cardiovascular mortality. Translational control shapes the proteome and is particularly important in regulating gene expression under stress.
They noted that, while such a preventative strategy was radical, if such a formulation existed that prevented cancer and was safe, it would be widely used. “It It is time to discard the view that risk factors need to be measured and treated individually if found to be abnormal.
Other common causes of pericarditis include bacterial infections, kidney failure, rheumatological conditions such as autoimmune conditions/vasculitis (SLE, rheumatoid arthritis, sarcoidosis) and even cancer (mesothelioma; spread from other tumors). Also recent cardiac surgery and a recent heart attack can present with pericarditis.
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