Cardiology Update

AUGUST 4, 2024

This includes beta-blockers, ACE inhibitors, ARBs, ARNIs, MRAs, and SGLT2 inhibitors. The 2021 European Society of Cardiology guidelines recommend guideline-directed medical therapy (GDMT) for patients with HF with reduced ejection fraction (HFrEF).

Heart Failure 119

Heart Failure ACE Inhibitor COVID-19 Quality of Life 119

Open Heart

DECEMBER 6, 2023

received ACE inhibitors or aldosterone receptor blockers (ACEIs/ARBs), 54.4% (CI 45.4 On random effects meta-analysis, 92.1% (95% CI 89.3 received at least one antiplatelet, 78.0% (CI 73.5 received beta-blockers, 58.7% (CI 52.3 were screened for fibromuscular dysplasia (FMD), and 70.2% (CI 60.8

SCAD 98

SCAD Cardiac Rehabilitation ACE Inhibitor Document 98

The American Journal of Cardiology

AUGUST 8, 2024

Publication date: Available online 7 August 2024 Source: The American Journal of Cardiology Author(s): Johanna A. van der Zande, Karishma P. Ramlakhan, Katja Prokselj, Edison Muñoz-Ortiz, Amalia Baroutidou, Magdalena Lipczynska, Edit Nagy, Tobias Rutz, Arie Franx, Roger Hall, Mark R. Johnson, Jolien W. Roos-Hesselink, ROPAC investigators

ACE Inhibitor 40

ACE Inhibitor 40

Dr. Paddy Barrett

NOVEMBER 29, 2024

Most people with high blood pressure will be treated with an ACE inhibitor, ARB, calcium channel blocker or a diuretic. 6 Mortality and Morbidity Among Individuals With Hypertension Receiving a Diuretic, ACE Inhibitor, or Calcium Channel Blocker: A Secondary Analysis of a Randomized Clinical Trial. There are others also.

Blood Pressure 71

Blood Pressure ACE Inhibitor Hypertension Cardiovascular Disease 71

Heart BMJ

OCTOBER 28, 2024

Resistant hypertension is a condition where blood pressure levels remain elevated above target despite changes in lifestyle and concurrent use of at least three antihypertensive agents, including a long-acting calcium channel blocker (CCB), a blocker of the renin-angiotensin system (ACE inhibitor or angiotensin receptor blocker) and a diuretic.

Hypertension 59

Hypertension ACE Inhibitor Blood Pressure Research 59

Heart BMJ

JANUARY 10, 2024

Time-updated adjusted Cox regression models were used to compare patients with and without RAS inhibitors. Subgroup analyses were performed, as well as a comparison between angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs). Both treatment with ACE inhibitors (aHR 0.89 (95% CI 0.82

Aortic valve 40

Aortic valve Aortic ACE Inhibitor Stenosis 40

Open Heart

APRIL 24, 2024

were on a beta blocker and on an ACE inhibitor/angiotensin receptor blocker/angiotensin receptor-neprilysin inhibitor, respectively. During the second period, and following the consultation, of the patients with HF with reduced ejection fraction (HFrEF), 86.4%

Heart Failure 52

Heart Failure Preserved Ejection Fraction ACE Inhibitor Pharmacology 52

Heart BMJ

MARCH 12, 2024

The aim of this study was to evaluate in a network meta-analysis if beta-blockers (BB) and ACE inhibitors/angiotensin receptor blockers (ACEi/ARBs), in combination or not, can effectively prevent TTS recurrences. Recurrences of TTS are not infrequent and there is no standard preventive therapy.

ACE Inhibitor 52

ACE Inhibitor Heart Failure Outcomes 52

Conquering CHD

JUNE 20, 2023

ACE Inhibitors WHAT THEY DO : ACE inhibitors block the angiotensin-converting enzyme (ACE) which causes narrowing of blood vessels. COMMON NAMES : Some common brand name ACE inhibitor drugs available to patients with CHD include lisinopril, ramipril and enalapril.

Congenital Heart Disease 52

Congenital Heart Disease Congenital Heart Disease ACE Inhibitor 52

Open Heart

NOVEMBER 8, 2023

Methods Randomised controlled trials (RCTs) were identified from Medline, Scopus up to June 2021.

Heart Failure 52

Heart Failure ACE Inhibitor Outcomes Pharmacology 52

Open Heart

DECEMBER 2, 2024

Methods HFrEF patients with symptomatic LVEF≤35% despite ACE inhibitor/beta blocker/mineralocorticoid receptor antagonist therapy, and qualified for sacubitril/valsartan switchover were recruited to this single centre prospective study. CMR was performed at baseline and at follow-up.

ACE Inhibitor 52

ACE Inhibitor Heart Failure Cardiomyopathy Outcomes 52

The British Journal of Cardiology

JANUARY 16, 2024

Twenty years ago, Wald and Law 1 hypothesised that, if a combination pill could be made including aspirin, folic acid, a statin, and a low-dose diuretic, beta blocker and angiotensin-converting enzyme (ACE) inhibitor (thus, allowing for the simultaneous modification of four different risk factors: low-density lipoprotein [LDL]-cholesterol, blood pressure, (..)

ACE Inhibitor 40

ACE Inhibitor Risk Factors Blood Pressure Cardiovascular Disease 40

DAIC

APRIL 6, 2024

The composite rate of total heart failure hospitalizations and death from heart failure was also 31% lower among those receiving empagliflozin.

Heart Attack 98

Heart Attack Heart attacks Heart Failure Outpatient 98

Stroke Journal

FEBRUARY 1, 2024

White with interaction by prevalent stroke status, adjusted for demographic and socioeconomic status.Results:Of 17,222 participants without prevalent stroke at Visit 1, Black participants had greater odds of ACE-inhibitor usage relative to White participants (OR 1.68, 95% CI 1.44-1.95).

ACE Inhibitor 40

ACE Inhibitor Stroke Strokes Blood Pressure 40

Heart BMJ

DECEMBER 15, 2023

At multivariable analysis, smoking habit (OR 2.28; p<0.0001), history of traumatic syncope (OR 2.29; p=0.0001) and ACE inhibitors/angiotensin II receptor blockers (OR 4.74; p<0.0001) were independently associated with SS. Patients with SS were older (48.8±20.0 ±20.0 ±19.1, vs 47.7%, p=0.001).

ACE Inhibitor 40

ACE Inhibitor 40

Open Heart

FEBRUARY 17, 2024

were on ACE inhibitors/angiotensin receptor blockers and 54.9% Results A total of 237 participants were included in the final analysis. The mean age was 61.3±17.36 years, and the majority (57.8%) were male participants. on beta-blockers.

Heart Failure 40

Heart Failure Quality of Life ACE Inhibitor COVID-19 40

Open Heart

APRIL 7, 2022

Those with sinus tachycardia were treated with beta-blockers and those with ventricular hypertrophy received a beta-blocker and ACE-inhibitor combination. This provided comprehensive rhythm surveillance and automatic downloads of all detections to a monitoring station for cardiology interpretation.

Arrhythmia 40

Arrhythmia ACE Inhibitor Download Tachycardia 40

Circulation

NOVEMBER 11, 2024

Cardiac MRI did not show significant ischemic findings.The patient received medical therapy consisting of antiplatelet agents, high dose statin, beta blocker and ACE inhibitor, as well as diuretics. Notably, the LAD had multiple aneurysmal segments and areas of eccentric stenosis upto 90%.Multislice

Coronary Artery Bypass Graft 40

Coronary Artery Bypass Graft ACE Inhibitor Coronary Angiogram Aneurysm 40

European Journal of Heart Failure

NOVEMBER 29, 2023

Methods and results Patients ( n  = 5661) included in the PARADISE MI trial (Prospective ARNI vs. ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events After MI) were stratified according to MRA. Primary outcomes in this substudy were worsening heart failure or cardiovascular death.

Myocardial Infarction 40

Myocardial Infarction ACE Inhibitor Heart Failure Pulmonary 40

DAIC

APRIL 6, 2024

The composite rate of total heart failure hospitalizations and death from heart failure was also 31% lower among those receiving empagliflozin.

Heart Attack 81

Heart Attack Heart attacks Heart Failure Outcomes 81

Circulation

NOVEMBER 11, 2024

Women received more discharge cardiac medications than men: antiplatelet agents, statins, beta blockers, ACE inhibitors, angiotensin II blockers, calcium channel blockers, and nitrates (p=0.0002 - 0.04).Follow-up Length of stay (LOS) in the CPU to discharge was 10.4

Chest Pain 40

Chest Pain ACE Inhibitor Cardiac Function Coronary Artery Disease 40

Physiologically Speaking

MARCH 6, 2024

ACE inhibitors block the angiotensin-converting enzyme to reduce blood pressure. Defining an exercise pill Experts who have commented on the idea of an exercise pill note one glaring issue: the term “exercise mimetic” is a not only a misnomer, but it’s inaccurate and misleading. Statins lower cholesterol.

Exercise 92

Exercise Blood Pressure Risk Factors Physiology 92

MIBHS

OCTOBER 31, 2024

Medications Medications are often the first line of treatment for cardiomegaly and can include: ACE inhibitors or ARBs , which help lower blood pressure and reduce the workload on the heart. The primary goals of treatment are to address the root cause, reduce the heart’s workload, and prevent complications like heart failure.

Blood Pressure 52

Blood Pressure Blood Clot Heart Valves Heart Rhythm 52

EMS 12-Lead

APRIL 14, 2022

ACE inhibitors, or potassium-sparing diuretics), are particularly susceptible. A brief review of the pathophysiology of hyperkalemia will help set the stage for the ECG changes inherent therein. Other causes include metabolic acidosis, in which hydrogen ions shift into the cells in exchange for potassium.

ACE Inhibitor 52

ACE Inhibitor Physiology Chest Pain Academic 52

EMS 12-Lead

MAY 8, 2022

ACE inhibitors, or potassium-sparing diuretics), are particularly susceptible. This ECG is pathognomonic for hyperkalemia. Predisposition to hyperkalemia is complex, but in general, patients with renal disease, or those taking medications that yield potassium retention (e.g.

ACE Inhibitor 52

ACE Inhibitor Ischemia Physiology STEMI 52

Dr. Smith's ECG Blog

NOVEMBER 15, 2023

associated typical Myocardial Infarction therapies such as statins and ACE inhibitors with significantly decreased 1 year mortality in MINOCA patients, which suggests that they do indeed have a similar pathophysiology to MI patients with obstructive coronary disease. Lindahl et al.

Coronary Angiogram 108

Coronary Angiogram Plaque Thrombosis STEMI 108

Dr. Malcolm Kendrick

OCTOBER 20, 2023

Whilst we had evidence (from drug company sponsored clinical trials) demonstrating that certain actions e.g., taking an ACE-inhibitor after a heart attack, reduced the risk of future heart attacks. I had many concerns, but I will just stick to one here. Or, if the interactions between all four drugs might cancel out any benefit.

Heart Attack 52

Heart Attack Heart attacks Blood Pressure ACE Inhibitor 52

Dr. Sanjay Gupta

MARCH 6, 2022

These include ACE inhibitors (medications such as ramipril, lisinopril, perindopril etc), beta-blockers (carvedilol, Bisoprolol, nebivolol), aldosterone antagonists (spironolactone), Entresto and now there is a new class of medications called SGLT2 inhibitors such as Dapagliflozin.

Heart Failure 40

Heart Failure Quality of Life ACE Inhibitor Exercise 40

Dr. Smith's ECG Blog

SEPTEMBER 30, 2019

The patient stated he had a long history of well-controlled hypertension for which he was compliant with his ACE-inhibitor. His pain radiated to his shoulders throughout the evening and the night but it did not prompt him to seek medical attention. He was also treated for erectile dysfunction but had not taken any medications recently.

Chest Pain 52

Chest Pain Pulmonary ACE Inhibitor Pacemaker 52

Dr. Sanjay Gupta

MAY 23, 2022

We now do have some really good medications that help do both and these include: ACE Inhibitors/Entresto Beta Blockers MRAs – Mineraloreceptor antagonists SGLT2 inhibitors And ideally anyone with heart failure should be on all these medications unless they are intolerant or in some way the medications are contraindicated.

Heart Failure 40

Heart Failure Pacemaker Quality of Life ACE Inhibitor 40

The British Journal of Cardiology

JULY 17, 2024

“In spite of the accumulating evidence of their efficacy, established treatments for maintaining renal function remain woefully underutilized. Clinicians and health care systems must be encouraged to make use of these treatments.”

Kidney Disease 40

Kidney Disease Outcomes Diabetes Heart Failure 40

Dr. Sanjay Gupta

DECEMBER 19, 2022

Another problem is that sometimes if you have myocardial involvement I.e

Pericarditis 40

Pericarditis Heart Attack Heart attacks Chest Pain 40

Dr. Sanjay Gupta

MARCH 6, 2022

These include ACE inhibitors (and now a medication called Entresto), beta blockers, Mineralocorticoid receptor antagonists and now a new class of anti-diabetic medications called SGLT2 inhibitors and ideally wherever possible the patient should try and take a little of all of them as opposed to taking lots of one and none of the others.

Chronic Disease 40

Chronic Disease Quality of Life Heart Failure Nursing 40

Dr. Smith's ECG Blog

NOVEMBER 30, 2022

associated typical Myocardial Infarction therapies such as statins and ACE inhibitors with significantly decreased 1 year mortality in MINOCA patients, which suggests that they do indeed have a similar pathophysiology to MI patients with obstructive coronary disease. Lindahl et al.

Plaque 52

Plaque Chest Pain Thrombosis Stenosis 52

Circulation

NOVEMBER 11, 2024

Methods:We analyzed data of ACE inhibitor naïve subjects with heart failure due to congenital heart disease (n=31) or dilated cardiomyopathy (n=3) from the prospective, open-label, multicenter phase II/III pharmacokinetic bridging studies using NONMEM®.

Heart Failure 40

Heart Failure Innovation ACE Inhibitor Congenital Heart Disease 40