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reduction in low-density lipoprotein (LDL) cholesterol, on average, six months after starting treatment. Nissen, MD , chief academic officer in the Heart, Vascular, and Thoracic Institute at Cleveland Clinic and the study’s lead author. of cases at baseline and at the final treatment phase assessment, respectively.
BackgroundElevated lowdensity lipoprotein cholesterol is a risk factor for atherosclerotic cardiovascular disease, including acute ischemic stroke (AIS), due to large and smallvessel disease. Cholesterol management guidelines recommend lipidlowering therapy (LLT) to prevent atherosclerotic cardiovascular disease events.
Key secondary and exploratory outcomes include improvement in a composite cardiovascular health metric, CR engagement, quality of life, health factors (including low‐density lipoprotein‐cholesterol, hemoglobin A1c, weight, diet, smoking cessation, blood pressure), and psychosocial factors.
Getty Images milla1cf Fri, 06/14/2024 - 19:30 June 14, 2024 — Until now, known risk factors for cardiac arrest have been limited to cardiovascular conditions such as hypertension and high cholesterol. million patients who sought care between 2010 and 2021 at UW Medicine, a large academic healthcare system in Seattle.
The open-data movement seeks to liberate the massive amount of data generated in running clinical trials from the grasp of the academic medical-pharmaceutical industrial complex that mostly runs the most important trials responsible for bringing novel therapeutics to market. Cholesterol lowering is big business. billion dollars.
This is a cholesterol lowering injectable drug, known as a PCSK9-Inhibitor. They all lower cholesterol (LDL) more than statins – hooray (or perhaps not). Cholesterol lowering is what the NHS now does. A place where money can be converted into both academic and medical authority. And nothing else!
Try publishing a paper suggesting that cholesterol lowering is a waste of time, when the market for cholesterol lowering drugs is worth hundreds of billions. To quote Peter Higgs: ‘ I wouldn’t be productive enough for today’s academic system.’ Today, researchers need to be productive and drive the income stream.
In my opinion, or should I say ‘allegedly’ what actually happened here was that Barney Calman had heard from various cardiology experts that cholesterol and statin ‘deniers’ were causing people to stop taking their drugs. Sorry, I know the answer to that. What actually happened? Had Barney ever read any of it?
I, Dr Malcolm Kendrick, with or without other co-conspirators, would be accused of spreading misinformation about cholesterol and statins. The hypothesis that a raised cholesterol level causes heart disease [atherosclerotic cardiovascular disease (ASCVD)] is possibly the single most powerful idea in medicine. With thousands dying.
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