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ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules

Journal of Clinical Investigation - Cardiology

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. Lipid accumulation and the expression of genes related to DNL were elevated in the kidneys of patients with fibrosis.

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Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification

Circulation

The role of 4-hydroxynonenal (4-HNE), which is the most abundant stable product of lipid peroxidation, in vascular calcification has been poorly investigated.METHODS:Serum was collected from patients with chronic kidney disease and controls, and the levels of 4-HNE and 8-iso-prostaglandin F2α were measured.

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The impact of early cryoballoon ablation on clinical outcome in patients with atrial fibrillation: From the Korean cryoballoon ablation registry

Journal of Cardiovascular Electrophysiology

Abstract Introduction Influence of early atrial fibrillation (AF) ablation, particularly cryoballoon ablation (CBA), on clinical outcome during long-term follow-up has not been clarified. Methods The study included 2605 patients from Korean CBA registry data with follow-up >12 months after de novo CBA. vs. 31.7%, p  = 0.043).

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Clinical Outcome of Cryoballoon Ablation for Long‐Standing Persistent Atrial Fibrillation: From the Korean Cryballoon Ablation Registry

Journal of Cardiovascular Electrophysiology

ABSTRACT Introduction Pulmonary vein isolation (PVI) by cryoballoon ablation (CBA) is considered an effective primary strategy for early persistent atrial fibrillation (AF). However, data regarding CBA for long-standing persistent AF (PeAF) are limited. We evaluated the efficacy and safety of CBA for long-standing PeAF compared to PeAF.

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Rate vs Rhythm Control in Atrial Fibrillation

All About Cardiovascular System and Disorders

Nearly two thirds in the rhythm control strategy were on amiodarone and only 14 had catheter ablation. That is how the strategy of rhythm control by catheter ablation was thought of as a possible better strategy, though technically more challenging, not uniformly effective and having significant risk of complications.

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Early Rhythm Control, Lifestyle Modification and More Tailored Stroke Risk Assessment Are Top Goals in Managing Atrial Fibrillation

DAIC

The updated guideline calls for a stronger, more prescriptive focus on healthy lifestyle habits to prevent or lessen the burden of AFib, as well as early and more aggressive rhythm control in general, including upgraded recommendations for catheter ablation as first line therapy to prevent disease progression.

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ACC/AHA Release Updated 2023 Guidelines for Atrial Fibrillation

Cardiometabolic Health Congress

Furthermore, it includes the latest recommendations which specifically address AF and thromboembolic risk assessment, anticoagulation, left atrial appendage occlusion, AF catheter or surgical ablation, and risk factor modification and AF prevention. As such, the Class of Recommendation for catheter ablation has been upgraded.