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PO-06-191 TRANSCATHETER EXTRACTION OF A FOSSA OVALIS FLAP PRESENTING AS ACUTE STROKE POST ATRIAL FIBRILLATION ABLATION

HeartRhythm

Strokes and silent ischemia remain a serious complication of atrial fibrillation catheter ablation (AFCA). This is mainly due to extensive ablation lesions in the left atrium that create large areas of endothelial injury that produces prothrombotic states during and after AFCA.

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Ventricular Tachycardia Management

All About Cardiovascular System and Disorders

Monomorphic ventricular tachycardia in the setting of acute myocardial ischemia can also be treated by intravenous lignocaine bolus followed by infusion. Predisposing causes for ventricular tachycardia like ischemia and electrolyte imbalance has to be treated simultaneously to prevent recurrence.

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What is the rhythm? And is there new left bundle branch block (LBBB)?

Dr. Smith's ECG Blog

Is there ischemia? ECG Diagnosis is either : 1) junctional rhythm with new LBBB, and possibly ischemia 2) accelerated idoventricular rhythm with possible ischemia, and possibly related to restoration of normal perfusion. Exactly how they relate to ischemia, chest pain, and reperfusion can only be speculated about.

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A fascinating electrophysiology case. What is this wide complex tachycardia, and how best to manage it?

Dr. Smith's ECG Blog

Are you confident there is no ischemia? Primary VT , and the VT with tachycardia is causing ischemia with chest discomfort (supply-demand mismatch/type 2 MI)? Ischemia from ACS causing the chest discomfort, with VT another consequence (or coincidence)? Do you agree with this strategy? How can you better assess the ST segments?

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What are treatment options for this rhythm, when all else fails?

Dr. Smith's ECG Blog

There is no definite evidence of acute ischemia. (ie, Simply stated — t he patient was having recurrent PMVT without Q Tc prolongation, and without evidence of ongoing transmural ischemia. ( Some residual ischemia in the infarct border might still be present. Both episodes are initiated by an "R-on-T" phenomenon.

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Types of Ventricular Tachycardia

All About Cardiovascular System and Disorders

Automatic ventricular tachycardia can occur in acute ischemia, electrolyte imbalance and with increased sympathetic tone. Radiofrequency catheter ablation is highly effective (85%-90%) in those with severe symptoms. Either case, the treatment is ablation of the right bundle. The sinus rhythm ECG can manifest an LBBB pattern.

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CRISPR-Cas9 base editing of pathogenic CaMKII? improves cardiac function in a humanized mouse model

Journal of Clinical Investigation - Cardiology

We have previously shown that ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing enables the heart to recover function from otherwise severe damage following ischemia/reperfusion (IR) injury. Here, we extended this therapeutic concept toward potential clinical translation.