Remove Ablation Remove Exercise Remove Ischemia
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CRISPR-Cas9 base editing of pathogenic CaMKII? improves cardiac function in a humanized mouse model

Journal of Clinical Investigation - Cardiology

We have previously shown that ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing enables the heart to recover function from otherwise severe damage following ischemia/reperfusion (IR) injury. Here, we extended this therapeutic concept toward potential clinical translation.

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American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

ET Main Tent (Hall B1) This session offers more insights from key clinical trials presented at ACC.24 24 and find out what it all means for your patients.

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A young woman with palpitations. What med is she on? With what medication is she non-compliant? What management?

Dr. Smith's ECG Blog

And superimposed subendocardial ischemia pattern, of course. Before continuing flecainide, he had me get on a treadmill at full dose and at full exercise (18 minutes) and measured the QRS to be certain that the QRS did not lengthen at all. Is this patient a candidate for cardioversion or ablation? ( Coincidence?).

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ECG Blog #371 — Palpitations Since Childhood.

Ken Grauer, MD

As discussed in ECG Blog #363 — this rare genetic disorder almost always presents in association with emotional stress or with exercise (ie, CPVT is usually "induced" by catecholamine discharge ). A left-sided lateral wall AP was found on EP study — and successfully ablated. Beyond-the-Core: Can You L ocalize the A P ?

Blog 78
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Young Man with a Heart Rate of 257. What is it and how to manage?

Dr. Smith's ECG Blog

The patient was found to have a "concealed" posteroseptal pathway (WPW without delta waves) confirmed to have SVT at EP study and was ablated. Here is the Electrophysilogist's note: "Only 1 pathway attachment could be ablated, the second one deep within the CS could not be ablated with high power.

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Electrical instability in a healthy 50 year old. How to manage?

Dr. Smith's ECG Blog

Previously healthy, taking no medication and exercising regularly. No anginal symptoms asymptomatic during physical exercise. That said there were no clinical symptoms or ECG findings suggestive of ongoing ischemia. The patient has been scheduled for a PVC ablation procedure. How will you manage this patient?