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Brugada syndrome (BrS) is a genetic heart disease that predisposes individuals to ventricular arrhythmias and suddencardiacdeath. Although implantable cardioverter-defibrillators (ICDs) and quinidine are primary treatments, recurrent BrS-triggered ventricular arrhythmias can persist.
Implantable cardioverter defibrillator (ICD) prevents suddencardiacdeath (SCD) in patients with ischemic cardiomyopathy (ICM). Catheter ablation has been shown to effectively reduce ventricular tachycardia (VT) recurrence, yet its efficacy in patients without an ICD implantation remains uncertain.
Recent advancements in catheter ablation for structural ventricular tachycardia (VT), such as high-density mapping and cardiac imaging-based detection of target areas, have significantly improved the efficacy of ablation procedures.
Patients with repaired tetralogy of Fallot are at risk of ventricular tachycardia (VT) and suddencardiacdeath. Historically, risk stratification electrophysiologic studies involved programmed ventricular stimulation with VT induction guiding implantable cardioverter-defibrillator (ICD) implantation or VT ablation.
Suddencardiacdeath remains the main killer of adults in industrialized countries and reentrant ventricular arrhythmia (VA) is its main underlying mechanism1.
Cardiovascular mortality, driven by suddencardiacdeath, is the main reason for dying while waiting for heart transplantation (HTx). Ablation will be performed with the use of a substrate-based approach in which the myocardial scar is mapped and ablated while the heart remains predominantly in sinus rhythm.
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterised by fibrofatty replacement of the ventricular myocardium due to specific mutations, leading to ventricular arrhythmias and suddencardiacdeath. Emerging evidence suggests that combining flecainide and bisoprolol may be efficacious.
All study participants never received alcohol septal ablation or surgical myectomy during follow-up. LV-GLS were derived from cine cardiac MRI by using feature tracking method. Circulation, Volume 150, Issue Suppl_1 , Page A4142952-A4142952, November 12, 2024. The primary endpoint was SCD or SCD-equivalent events. vs -266.2;
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