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ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers

Journal of Clinical Investigation - Cardiology

Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified.

Cancer 116
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Selection of rhythm intervention strategies in atrial fibrillation patients with cancer and efficacy and safety of catheter ablation

Frontiers in Cardiovascular Medicine

BackgroundThe risk of comorbidity of cancer is increased in atrial fibrillation (AF) patients, which is a massive challenge for clinical management in cardiovascular settings. The propensity score matching method was utilized to balance the differences between the cancer and non-cancer groups. 1.83, P = 0.62).ConclusionsThe

Cancer 40
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STS Announces Late-breaker Research to Be Presented at the 2024 Annual Meeting

DAIC

The researchers found that Medicare patients undergoing esophagectomy for cancer exhibit identifiable predictors for long-term survival and readmission. These findings suggest opportunities to enhance clinical practice and improve outcomes for Medicare patients undergoing esophagectomy for cancer.

Research 111
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Atrioventricular re-entrant tachycardia and atrioventricular node re-entrant tachycardia in a patient with cancer under chemotherapy: a case report and literature review

Frontiers in Cardiovascular Medicine

Here, we report a patient with new-onset AVRT/AVNRT and lung cancer who underwent chemotherapy. We considered that chemotherapy or cancer itself may have been a trigger for the initiation of paroxysmal AVRT/AVNRT, and that radiofrequency catheter ablation was effective in treating this type of tachycardia.

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Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells

Journal of Clinical Investigation - Cardiology

Fusobacterium nucleatum is frequently associated with the onset and progression of colorectal cancer (CRC). Functional studies showed that genetic ablation of Ly6a in intestinal epithelial cells or Rps14 in LY6A+ RSCs substantially reduced F. In this study, we uncovered that F. Upon binding, F. nucleatum colonization and tumorigenesis.

Cancer 40
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USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis

Journal of Clinical Investigation - Cardiology

USP47 positively correlated with the tumor-infiltrating Treg signature in samples from patients with colorectal cancer and gastric cancer. USP47 ablation compromised Treg homeostasis and function in vivo, resulting in the development of inflammatory disorders, and boosted antitumor immune responses.

Cancer 45
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American College of Cardiology ACC.24 Late-breaking Science and Guidelines Session Summary

DAIC

12:15 p.m.